@Total_syn_guy

IIT Roorkee Alumnus || Ph.D. IIT Kanpur || Total Synthesis, Hypervalent Iodine, Cascade Reactions, computaional chemistry||

 IIT Kanpur
Joined May 2015
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  • Following332
  • Followers65
Another publication in Organic Letters! Acetate-Walking-Triggered Cycloaddition Cascades: Pd(0)-Catalyzed Access to syn-Dihydronaphthalenes via Ring Deletion pubs.acs.org/doi/10.1021/acs… @JOC_OL @ANRFIndia @Chemistry_IITK @SINGHSHUBHAM44 @Total_syn_guy @ParthaS_IITK @kumarabhi181299

Acetate Walking-Triggered Cycloaddition Cascades: Pd(0)-Catalyzed Access to syn-Dihydronaphthalenes...

Abstract. We report a Pd(0)-catalyzed cascade that enables the stereoselective synthesis of syn-1,4-dicarbinol dihydronaphthalene esters through regiotermi

pubs.acs.org
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Excited to share our recent publication in Organic Letters! “Solvent-Controlled Divergent Catalysis toward the Synthesis of Fluvastatin Analogs” pubs.acs.org/doi/10.1021/acs… @JOC_OL @ANRFIndia @Chemistry_IITK @ParthaS_IITK @athiraparammal @ARUPJYOTI_94

Solvent-Controlled Divergent Catalysis toward the Synthesis of Fluvastatin Analogs

Abstract. A solvent-controlled, divergent Rh(III)-catalyzed strategy enables the synthesis of structurally diverse fluvastatin analogs. Enantioenriched α,β

pubs.acs.org
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Delighted to share our work on the cyclotrimerization of tethered tetraynes to access para-diethynylbenzenes, recently out in Organic Letters. Many congratulations to Rajesh Chakrabortty and Tamal Ballav for their efforts. Please read it here. pubs.acs.org/doi/full/10.102…
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Happy to share our recent work on "Nickel-Catalyzed Ortho-C(sp3/sp2 ) Functionalization of Free Halobenzoic Acids". Many congratulations to Aniruddha, Tamal, and our collaborator Prof. Michael Greaney, Univ. of Manchester. advanced.onlinelibrary.wiley…

Nickel‐Catalyzed Ortho‐C(sp3/sp2) Functionalization of Free Halobenzoic Acids

We report a Ni(0)-catalyzed radical-mediated ortho-alkylation of 2-halobenzoic acids that effectively addresses the challenges of over-alkylation and β-hydride elimination. Katritzky's salts derived...

advanced.onlinelibrary.wiley.com
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Our follow-up full paper on the Nickel-Catalyzed Cyclotrimerization appeared online in Advanced Synthesis & Catalysis. Many Congratulations to Rajesh and Suman! Please read it here. advanced.onlinelibrary.wiley…

Regioselective Construction of Hexa‐Substituted Alkynyl Benzenes via Ni(0)‐Catalyzed [2+2+2]...

We report a regioselective Ni(0)-catalyzed [2 + 2 + 2] cyclotrimerization of 1,3-diynes to synthesize hexa-substituted benzenes (HSBs). This versatile method accommodates diverse symmetrical and...

advanced.onlinelibrary.wiley.com
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@Chemistry_IITK @ParthaS_IITK @Total_syn_guy @cursed_catalyst
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Excited to share our latest work! The design and synthesis of aculeatin oxo-analogues and natural products enabled by an oxo-carbenium ion cyclization. #OrganicChemistry #TotalSynthesis #NaturalProducts #SyntheticChemistry @Chemistry_IITK @ParthaS_IITK pubs.rsc.org/en/content/arti…

Design and synthesis of aculeatin oxo-analogues and aculeatin natural products enabled by oxo-car...

Aculeatin natural products are potent anti-protozoal agents isolated from Amomum aculeatum, demonstrating high cytotoxicity against KB cell lines (IC50 = 0

pubs.rsc.org
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We are delighted to share that Mr. Manoj Kumar, PhD scholar from the Department of Chemistry, has been awarded the Best Poster Award at the 35th CRSI National Symposium in Chemistry, held at IIT Gandhinagar. His poster, supervised by Prof. Parthasarathi Subramanian, was recognised. Congratulations to Mr. Manoj Kumar on this noteworthy achievement! #IITKanpur #ResearchExcellence #Chemistry #CRSI2025 #BestPosterAward #IITKStudents #InnovationInResearch @iitgn
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Glad to share this diastereo-enantio-chemoselective @totalsynthesis of (-)-calycanthidine & formal total synthesis of (-)-idiospermuline just out on @ChemCommun. Congrats to @Kundanchem14 @debabrata1debu @ShyamalPranay & @arindamkhatua for this article👏 pubs.rsc.org/en/content/arti…
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Thrilled to share our recent work on Pd(0)-catalyzed (3+3) annulation of VCPs with boronic acid derivatives is now published in ChemCatChem. Big thanks to my supervisor @ganistry2002 @GroupGanesh for the support and @CompoSciTian_SM for cooperation 💐💐 doi.org/10.1002/cctc.2025007…

Pd(0)‐Catalyzed (3 + 3) Annulation of Vinylcyclopropanes and Boronic Acid Derivatives: A Route to...

Synthesis of vinyltetralones via a Pd(0)-catalyzed (3 + 3) annulation between vinylcyclopropanes and boronic acid derivatives is developed. Structurally diverse vinyltetralone frameworks were...

chemistry-europe.onlinelibrary.wiley.com
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Versatile Butenolide Syntheses via a Structure-Oriented C–H Activation Reaction Reference pubs.acs.org/doi/10.1021/jac… @J_A_C_S @isciverse #Chemistry #chemed #scicomm #news #Technology #Tech #TIC2025 #research #science #AcademicTwitter
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Manoj Kumar proudly represented our group at the 35th CRSI (@ChemResSocIndia) National Symposium in Chemistry, held at IIT Gandhinagar, where his poster was honored with the Best Poster Prize. Congratulations on this outstanding achievement.
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Congratulations to Brijesh, Mahesh, and Pritam on receiving their M.Sc. degrees at the 58th Convocation of IIT Kanpur. Pritam got awarded the Silver Medal for his exceptional work on the synthesis of platensimycin. Wishing them all the best in their future.
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One step closer to earning a Ph.D.! Shubham and Athira completed the open seminar.
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We say: time to spiro! A fantastic work from Marylise Triacca in collaboration with @AstraZeneca: Out in Green Chem: #eSpiro – a metal-free, scalable electrosynthetic route to spiroketals via anodic oxidation. pubs.rsc.org/en/content/arti… #OrganoEchem #GreenChem #RealTimeChem
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3-Oxabicyclo[3.1.1]heptane as an Isostere of meta-Benzene (Pavel K. Mykhailiuk and co-workers) @Mykhailiukchem @EnamineLtd #AngewandteVIP #openaccess 🔓 onlinelibrary.wiley.com/doi/…

3‐Oxabicyclo[3.1.1]heptane as an Isostere of meta‐Benzene

3-Oxabicyclo[3.1.1]heptanes were designed as saturated isosteres of meta-benzene. Crystallographic analysis revealed that these structures and meta-benzene have identical geometric properties....

onlinelibrary.wiley.com
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Our three brilliant M.Sc. students, Pritam, Brijesh, and Maheshwar, showcased their outstanding research, concluding their master’s journey with us. Wishing them a heartfelt farewell and success in their exciting future careers. @ParthaS_IITK @SinghSubham44
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We’re excited to share our work that introduces singly N-protected O-vinylhydroxylamines as ring-annulation reagents for the synthesis of azaindolines and azaindoles. Congrats to Zach & Charlotte (@charlie_bird13) and the Enamine (@EnamineLtd) team! 🔗 chemrxiv.org/engage/chemrxiv…
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Honored to share that our work "The Total Synthesis of Aspidofractinine and Related Alkaloids" was a Top Viewed Article in European Journal of Organic Chemistry (2023)! Article link 🔗 chemistry-europe.onlinelibra… #OrganicChemistry #TotalSynthesis #EurJOC #ResearchHighlight #Wiley
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From concept to compound: happy to share our recent publication: A versatile approach toward enantiospecific synthesis of sugar-linked oxapolyquinanes via IPKR - now published in Organic & Biomolecular Chemistry pubs.rsc.org/en/content/arti… @KrishnaPKaliap1 @Chemistry_IITB @iitbombay

A versatile approach toward enantiospecific synthesis of sugar-linked oxapolyquinanes via IPKR†

An efficient and enantiospecific synthetic strategy for the construction of [6/5/5/5] and [5/5/5/5] fused oxatetraquinanes using a d-glucose-derived enyne

pubs.rsc.org
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