#IBD #Crohns #colitis #coloncancer #nutrition #microbiome #digestivehealth #endoscopy #clinicaltrials Intensive, expert care.
Toronto, Canada
Joined September 2019
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Toronto Immune and Digestive Health Institute retweeted
Attn. General Surgeons, fellows, residents, PAs: Join us Sat.,Nov.7 for 2026 OAGS Surgical Symposium #TorontoOntario๐ Early bird registration exp: Oct 24. Hotel rate expires today: Oct.16. (final ext.) Details/Reg:rebrand.ly/e4ti4n7 #OAGS2026 #generalsurgery #meded
Toronto Immune and Digestive Health Institute retweeted
1/7 85-86% of IBD patients in remission report food intolerances, versus 33% of controls. A Gastroenterology paper argues inflammation causes this: colitis depletes the bacteria that digest dairy proteins, and colonic mast cells do the rest.
gastrojournal.org/article/S0โฆ
Toronto Immune and Digestive Health Institute retweeted
In this episode of Bottom Line, Jocelyn Laidlaw speaks with Manitoba oncologist Dr. Ralph Wong about rising colorectal cancer rates in younger Canadians, symptoms to watch for, later-stage diagnoses, and why screening should start at 45. Watch: youtu.be/KZjEiqDfdjE
Toronto Immune and Digestive Health Institute retweeted
Part three of the IBD pipeline series. Not just whatโs coming... but when.
Iโve mapped every phase 3 trial in UC and Crohnโs against ClinicalTrials.gov. Start date to primary completion. Company and NCT number for each.
16 phase 3 studies still to complete. 12 of them are due in 2028.
All three anti-TL1As (the first wave - there are others stacking up behind). Oral IL-23R (icotrokinra) in UC and Crohnโs. Co-formulated gus + golimumab. Mirikizumab plus tirzepatide.
Two have already delivered (*press release only as of today). Obefazimod: positive phase 3 in UC, US filing planned for Q4. Tulisokibart: positive UC induction study in June. Next up... afimkibart in UC, due to complete about now.
Most of these are recruiting today. Every patient we offer a trial brings 2028 closer.
Toronto Immune and Digestive Health Institute retweeted
Part four of the IBD pipeline series - phase 2.
22 programmes to watch in UC and Crohn's. Start to primary completion, company and NCT number for each.
12 of them are due to complete by the end of 2027.
And some of it lands NEXT WEEK at UEG in Barcelona.
Sunday: Spyre's three long-acting antibodies in UC
Monday: first data for Gilead's oral ฮฑ4ฮฒ7 (emvistegrast)... and risankizumab plus an anti-ฮฑ4ฮฒ7 in Crohn's (ABBV-466). Both late-breakers.
Tuesday: RIPK2 (OD-001), PSGL-1 (ALTB-268) and an anti-fibrotic for stricturing Crohn's (ontunisertib)
Three have passed primary completion with nothing out yet. Zasocitinib in UC (Takeda says data by March 2027). Eltrekibart (Lilly). AZD7798 (AstraZeneca).
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Do you remember when you joined X? I do! #MyXAnniversary
Toronto Immune and Digestive Health Institute retweeted
How can Canada build a stronger clinical trials system now?
Join experts for a panel on practical solutions, national alignment, and collaboration to accelerate innovation across Canada.
๐ tinyurl.com/PACT-2026
Toronto Immune and Digestive Health Institute retweeted
Boom RCT๐ฅ in @AGA_Gastro
Home calpro monitoring didnt reduce UC flare risk.
Blow to UC monitoring/T2T? More likely reflects need for mandated intervention (not doctor discertion) and for effortless monitoring methods (not often-skipped poop handling)
share.google/izEYhHmJhGrUaXVโฆ
Toronto Immune and Digestive Health Institute retweeted
๐ง In children with acute severe #ulcerativecolitis, intestinal ultrasound helped identify patients unlikely to respond to first-line therapy and at higher risk for colectomy.
๐ ow.ly/o5Rr50ZwBkk
#PedsGI
Toronto Immune and Digestive Health Institute retweeted
From @CTVNews : Swedish study reinforcing what Canadian IBD experts have been saying for years - mental-health challenges often emerging years before patients are formally diagnosed. @getgutsycanada @ludvigsson
ctvnews.ca/health/article/swโฆ
Toronto Immune and Digestive Health Institute retweeted
Your best trial starts with the right people.
From global pharmaceutical companies to emerging biotechs, Alimentiv brings scientific rigor, operational excellence, and authentic collaboration to every program we touch.
Find out how we can help advance your program, wherever you are in your pipeline ๐ loom.ly/xyE2kRE
#ClinicalResearch #Gastroenterology #GIIsOurWhy
Toronto Immune and Digestive Health Institute retweeted
A diet with <1 ultraprocessed food serving/day is associated with a 50% reduced 20-year IBD risk in Western populations
โ
The lowest consumption of ultraprocessed foods, the lowest risk of IBD
โ
The negative impact may be mediated by:
๐ธ Disruption of the gut microbiome
๐ธ โฌ๏ธ intestinal permeability from additives such as emulsifiers (eg, carboxymethylcellulose) and preservatives
โ
โฌ๏ธ UPF consumption could help mitigate the rising global burden of IBD
๐ Read the full research from @NarulaNeeraj & colleagues in @AGA_Gastro: gastrojournal.org/article/S0โฆ
Toronto Immune and Digestive Health Institute retweeted
Colorectal Cancer Canada is proud to have signed the Canadian Cancer and Work Charter.
By joining this movement, we are dedicated to ensuring no one faces cancer alone in the workplace.
Learn more at: cancerandwork.ca
Toronto Immune and Digestive Health Institute retweeted
You canโt always see IBDโbut it impacts everything.
Victoria Tyler is an influencer and patient advocate living with ulcerative colitis and a permanent ostomyโand sheโs using her platform to speak openly about what life with IBD really looks like.
Sheโs turning her experience into something others can see, understand, and talk about.
Watch her story and visit: bit.ly/4eJtezE for more stories from people living with IBD and resources.
Toronto Immune and Digestive Health Institute retweeted
Drink your coffee black (no additives) if you want the full health benefits.
2-3 cups per day has been associated with a 25% reduction in all-cause mortality. That benefit goes away when cream and/or sugar are added.
I think this happens for a few reasons:
โข Dairy proteins can bind to coffeeโs antioxidants and polyphenols and slow their absorption.
โข Heavy cream, butter, and MCT-heavy coffee donโt necessarily block coffee polyphenols, but they can add substantial saturated fat and calories. For someone watching ApoB or LDL-C, this can work against the very cardiovascular benefits theyโre hoping to get from coffee.
Toronto Immune and Digestive Health Institute retweeted
๐ฃ Join the upcoming @D_ECCO_IBD webinar on the role of diet in #IBD prevention
โ
Animal vs plant protein in IBD
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Lights and shadows of ultraprocessed foods in the onset of IBD
โ
To fiber or not to fiber in IBD
โ
Dietary patterns during early lige and IBD risk
๐ 24 June
โฐ 18:00-19:20 (CEST)
๐@VaioSvolos, @sarbagili, @Alice_APD, @vds_julie1 & Alicia Sandall
ECCO membership is needed for registration
๐๐ป Access the full program and register here: ecco-ibd.eu/education/webinaโฆ
Every day is #IBD day for the Team at TIDHI. Itโs why we exist! #WorldIBDDay
Toronto Immune and Digestive Health Institute retweeted
@TorDigHealthIns team is excited to join the Gutsy Walk 2026! ๐
Weโre proud to support the IBD community through patient care, research, and advocacy. Every donation helps make a difference for those living with Crohnโs disease and ulcerative colitis ๐
crohnsandcolitiscanada.akaraโฆ
Toronto Immune and Digestive Health Institute retweeted
Ontario becomes the second province to change the colorectal cancer screening age from 50 to 45. Coming in effect on July 1st, it will now be possible for a wider reach of Ontarians to qualify and be provided with a colorectal cancer test kit and the possibility of colonoscopies.
Toronto Immune and Digestive Health Institute retweeted
๐ก๐ผ ๐ผ๐ป๐ฒ ๐ต๐ฎ๐ ๐ฑ๐ผ๐ป๐ฒ ๐บ๐ผ๐ฟ๐ฒ ๐๐ ๐ฐ๐น๐ถ๐ป๐ถ๐ฐ๐ฎ๐น ๐๐ฟ๐ถ๐ฎ๐น๐ ๐๐ต๐ฎ๐ป ๐๐น๐ถ๐บ๐ฒ๐ป๐๐ถ๐.
That experience is more than a number โ it reflects decades of scientific leadership, deep therapeutic expertise, and longstanding partnerships across the global GI community.
While generalist CROs treat GI as part of a broader portfolio, Alimentiv brings full-spectrum, GI-exclusive expertise to every phase of clinical development. Weย bringย unmatched GI expertise toย every endpoint, every site, every phase.ย That is how we build exceptional outcomes.
Sponsors who partner with Alimentiv gain:
๐ฌ A specialized GI CRO with 30+ years of unmatched trial experience, having supported ๐บ๐ผ๐ฟ๐ฒ ๐๐ต๐ฎ๐ป ๐ณ๐ฌ% ๐ผ๐ณ ๐๐๐ ๐ฐ๐ผ๐บ๐ฝ๐ผ๐๐ป๐ฑ๐ ๐ถ๐ป ๐ฑ๐ฒ๐๐ฒ๐น๐ผ๐ฝ๐บ๐ฒ๐ป๐
๐ฅ Access to a global network of GI KOLs and investigators built over decades
๐ End-to-end clinical services supported by ๐ฑ,๐ฌ๐ฌ๐ฌ+ ๐๐ถ๐๐ฒ๐ ๐ถ๐ป ๐ฒ๐ฌ+ ๐ฐ๐ผ๐๐ป๐๐ฟ๐ถ๐ฒ๐
๐ฏ The scale, structure, and discipline required to deliver optimal trial outcomes
๐ช๐ต๐ฒ๐ป ๐๐ ๐๐ฐ๐ถ๐ฒ๐ป๐ฐ๐ฒ ๐ถ๐ ๐ฐ๐ผ๐บ๐ฝ๐น๐ฒ๐
๐ฎ๐ป๐ฑ ๐๐ต๐ฒ ๐๐๐ฎ๐ธ๐ฒ๐ ๐ฎ๐ฟ๐ฒ ๐ต๐ถ๐ด๐ต, ๐๐ฝ๐ฒ๐ฐ๐ถ๐ฎ๐น๐ถ๐๐ฎ๐๐ถ๐ผ๐ป ๐บ๐ฎ๐ธ๐ฒ๐ ๐๐ต๐ฒ ๐ฑ๐ถ๐ณ๐ณ๐ฒ๐ฟ๐ฒ๐ป๐ฐ๐ฒ.
Connect with Alimentiv at #DDW2026, May 2โ5 in Chicago.
#GIIsOurWhy #ClinicalResearch #CRO