Today we are announcing Topos-2, our next-generation model for generating the full range of shapes a protein can take, across the order-disorder spectrum. We are also previewing Topos-Bind: to our knowledge, the first generative model to capture the range of shapes for disordered proteins bound to small molecules. Read the technical blog post here: toposbio.ai/topos-2-topos-bi… (1/7)

Announcing Topos-1, an all-atom generative model that sets a new benchmark for predicting structural ensembles of intrinsically disordered proteins. Topos-1 outperforms existing models by a large margin, with implications for designing drugs for challenging targets ranging from cancer to neurodegenerative disease. Read the full technical report on our website: toposbio.ai/tech-report

Using Topos-1, we generated conformational ensembles that provided drug design insight and lead to computational predictions of drug potency that are in good agreement with tests performed in our laboratory.