@TomJackson1995

Postdoctoral Fellow in the Puigserver lab at the Dana-Farber Cancer Institute and Harvard Medical School

 Boston
Joined September 2018
  • Tweets33
  • Following443
  • Followers189
New preview just published in Molecular Cell! We highlight exciting work by Chen et al. identifying an arginine sensing axis mediated by BAG2 and SAMD4B that promotes survival under arginine deficiency. authors.elsevier.com/c/1lN5t…
1
4
17
1,321
💫NEW by @puigserver_lab & co: the chaperone PPID drives insertion of the #mitochondria import receptor TOM70 into the mitochondrial outer membrane, regulating body temperature, glucose homeostasis and body weight in #obese mice. 👉rdcu.be/d8atv nature.com/articles/s41556-0…
2
17
31
4,939
Thanks to @FrezzaLab for the great News & Views on our new paper in @NatureCancer! nature.com/articles/s43018-0…

Fine-tuning tumor immunogenicity with mitochondrial complex I

Nature Cancer - Targeting mitochondrial metabolic activity is an active area of cancer research. A study now finds that a selective deficiency in mitochondrial complex I in melanoma cells increases...

nature.com
3
6
547
Great to see this exciting work published showing how tumor mitochondria can be targeted to enhance anti-tumor immunity. Happy to have been able to contribute!
Tevis Vitale@TevisVitale17 Jan 2025
After much anticipation, I'm glad to say that the first paper from my Ph.D. is now out in @NatureCancer! Thanks to all the co-authors for their input and hard work! nature.com/articles/s43018-0… Below is a 🧵detailing our results 1/7

Selective deficiency of mitochondrial respiratory complex I subunits Ndufs4/6 causes tumor immuno...

Nature Cancer - Puigserver and colleagues show that genetic targeting of specific mitochondrial respiratory complex I subunits in melanoma and breast cancer cells boosts tumor immune surveillance...

nature.com
2
6
610
New article by @platorremuro published in @NatureCellBio Molecular mechanisms of ER stress-inducible chaperones mediating outer mitochondrial membrane TOM70 insertion protective against diet-induced obesity and diabetes rdcu.be/d5ptF
4
6
2
35
5,269
New paper by @platorremuro published in @CellCellPress! We combined thermoregulatory physiology, structural and computational approaches to determine the mechanisms of electron transfer and structural basis of respiratory complex adaptation to cold temperatures.
9
19
2
70
19,857
Amazing to see our work on the mitochondrial CLPB disaggregase finally published in @JCellBiol! Thank you @DrDStojanovski and @UniMelbMDHS for all your support! CLPB disaggregase dysfunction impacts the functional integrity of the proteolytic SPY complex rupress.org/jcb/article-abst…

CLPB disaggregase dysfunction impacts the functional integrity of the proteolytic SPY complex

Baker et al. demonstrate dysregulation of the intermembrane space disaggregase CLPB leads to aggregation of local quality control proteins, including SPY c

rupress.org
1
2
7
2,164
Excited to share our latest preprint by postdoc @platorremuro in collaboration with @vivekvivsharma and #LiaoLab. We combined #physiology and #cryoem to determine respiratory supercomplex adaptation in brown adipocytes in response to cold environments: biorxiv.org/content/10.1101/…

Structural basis of respiratory complexes adaptation to cold temperatures

In response to cold, mammals activate brown fat for respiratory-dependent thermogenesis reliant on the electron transport chain ([1][1], [2][2]). Yet, the structural basis of respiratory complex...

biorxiv.org
1
19
1
57
8,170
New studies from @puigserver_lab at @DFCI_CancerBio @HarvardCellBio finding Mitoribosome Quality Control as protective mechanism against pathogenic human mitochondrial disease mutations, published @emboreports embopress.org/doi/full/10.15…
2
21
1
70
9,336
New area of study from our research program on mitochondrial biology; “Selective Mitochondrial Respiratory Complex I Subunit Deficiency Causes Tumor Immunogenicity”, including sensitization to immune checkpoint blockade; pre-print at @biorxivpreprint; biorxiv.org/content/10.1101/…

Selective Mitochondrial Respiratory Complex I Subunit Deficiency Causes Tumor Immunogenicity

Targeting of specific metabolic pathways in tumor cells has the potential to sensitize them to immune-mediated attack. Here we provide evidence for a specific means of mitochondrial respiratory...

biorxiv.org
1
13
2
52
9,929
Our latest paper published now in @NatureComms: Epigenetic suppression of PGC1α can sensitize BRAFi-resistant melanomas to HMGCR inhibitors, check it out! nature.com/articles/s41467-0… @DFCI_CancerBio @HarvardCellBio @GygiLab @bwhdermatology
3
16
1
64
11,730
WE'RE HIRING! ☀️ Clemons Lab @PeterMacRes is expanding and looking for a talented postdoc or research assistant to help investigate immunotherapies in gastro-oesophageal cancers. If you have 🐁 experience and interest in cancer biology, join our team! Details/apply 👇 Please RT!
1
25
28
6,945
Great work from the big man @KenjiFujihara and @Clemons_Lab. Excellent study showing that eprenetapopt can induce ferroptosis. Great to watch the project develop over the years, and happy to have had the opportunity to be involved.
This Post is from an account that no longer exists. Learn more
5
So excited to see @JessicaSpinel16 present next week! It is sure to be some beautiful and elegant #biochemistry for #mito enthusiasts!
MitoTalks Down Under@MitoTalksDU20 Mar 2022
We are back for another year of MitoTalks Down Under! We are excited to announce @JessicaSpinel16 from the @WhiteheadInst will kick things off by showing us the untapped potential of the electron transport chain! Join us Tues 29th of March at 11 am AEDT to hear all about it!
3
17
Many of us have done sodium carbonate extractions to determine the membrane association of a single protein, but have you done it on >840 mitochondrial proteins at the same time, across two pH and multiple KO cell lines? Check out our new paper on SCE-MS: frontiersin.org/article/10.3…
3
14
2
91
Looking forward to hearing all about some amazing mitochondrial biology!!
MitoTalks Down Under@MitoTalksDU16 Aug 2021
We are excited to announce Prof. Thomas Langer @langer_lab from @MPIAGE will be our next guest speaker for @MitoTalksDU! Interested in how proteases reprogram mitochondrial function? Be sure to lock this one in your calendar! Check out the details below 👇
1
1
9
Stojanovski &co @DrDStojanovski @Bio21Institute @UniMelb use STORM to visualise the distribution of mitochondrial complexes at the nanoscale; more in our free Research highlight: ow.ly/k2bB50FEvvp
3
1
18
This Sunday we are teaming up with @DrDStojanovski lab to form the @Bio21Institute Blazers and walking 35km in the @bloodylongwalk to raise funds for #mitochondrialdisease. Check out this video I made with @daniellahock and the legend Noah about how the walk supports our work 👇
1
12
1
39
Tom Jackson retweeted
Mike Ryan@MikeRmitolab20 Apr 2021
Very happy to see our paper "Optic Atrophy-associated TMEM126A as an assembly factor for the ND4-module of Mitochondrial Complex" now out in PNAS. Thanks to lead @drlukey_form plus @ReljicBoris @alicejsharpe @daniellahock @linden_mw @thestroudlab pnas.org/content/118/17/e201…

Optic atrophy–associated TMEM126A is an assembly factor for the ND4-module of mitochondrial complex...

Mitochondrial disease is a debilitating condition with a diverse genetic etiology. Here, we report that TMEM126A, a protein that is mutated in pati...

pnas.org
9
24
2
118
We are excited to announce the next speaker for MitoTalks Down Under- @A_Amunts Assoc. Prof. Alexey Amunts! Join us for a Mitoribosome Odyssey on the 29th of April at 4pm AEST. Register here: forms.gle/1U4G9HPHnbmDQbQ9A Zoom details to follow soon!
9
1
29
Load more