Molecular Neurodegeneration Research Group at @NDCNOxford based at @KavliOxford. Researching Parkinson’s pathogenesis aiming to identify targets for therapies.
@UniofOxford
Joined May 2023
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Congratulations to everyone involved! 👏 Specially to our DPhil student, Hung-Ju Chueh 🎉 Awesome work!
science.org/doi/10.1126/scit…
@NDCNOxford @KavliOxford
Thrilled to share our latest paper @ScienceTM! We found that human microglia clear intraneuronal α-synuclein aggregates by GPNMB-mediated trogocytosis. science.org/doi/10.1126/scit…
Tofaris Lab retweeted
NEW: Oxford researchers have discovered how specialised immune cells in the brain can remove harmful protein clumps from neurons, opening up potential new avenues for treating Parkinson’s disease.
Parkinson's disease affects more than 10 million people worldwide.
Read more ⬇️
ox.ac.uk/news/2026-10-06-bra…
ALT A 3D reconstruction of a super-resolution microscopy image showing a brain immune cell (microglia) in green, with yellow, pink and blue structures representing cellular components and proteins. The image accompanies Oxford research into how brain immune cells remove harmful protein clumps associated with Parkinson’s disease.
Tofaris Lab retweeted
Dutta et al. show that extracellular vesicle-associated α-synuclein differs in conformation and distribution across Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. shorturl.at/B5xC4
Tofaris Lab retweeted
Another week, another paper for @GeorgeTofaris & colleagues
This week, they report the epitope accessibility & topology of extracellular vesicle-associated α-synuclein proteoforms, rather than their abundance alone, discriminate synucleinopathy subtypes
academic.oup.com/brain/advan…
New paper alert!
Have a look at our latest publication 📝
doi.org/10.1093/brain/awag35…
@KavliOxford @NDCNOxford
Delighted to share our latest @TofarisLab paper in @Brain1878 by @_Suman_Dutta et al. Using dSTORM to map the topology of extracellular vesicle-associated α-synuclein, we identified disease-associated conformers in both brain- and blood-derived EVs.
academic.oup.com/brain/advan…
Tofaris Lab retweeted
Bulk EV measurements can obscure disease-associated molecular heterogeneity.
Using single-vesicle analysis, we mapped distinct αSyn topologies in PD, DLB & MSA, with signatures detectable in brain & blood @TofarisLab @KavliOxford
Published in @Brain1878
doi.org/10.1093/brain/awag35…
Tofaris Lab retweeted
Delighted to share our latest @TofarisLab paper in @Brain1878 by @_Suman_Dutta et al. Using dSTORM to map the topology of extracellular vesicle-associated α-synuclein, we identified disease-associated conformers in both brain- and blood-derived EVs.
academic.oup.com/brain/advan…
Don't miss out on our previous publication either! 📖
nature.com/articles/s41467-0…
@NDCNOxford @KavliOxford
Thrilled to share our latest paper! We show that early α-synuclein toxicity in human neurons is mediated by impaired ER co-translational protein translocation, providing a unifying mechanism underlying diverse genetic modifiers in #Parkinson's nature.com/articles/s41467-0…
Tofaris Lab retweeted
Thrilled to share our latest paper @ScienceTM! We found that human microglia clear intraneuronal α-synuclein aggregates by GPNMB-mediated trogocytosis. science.org/doi/10.1126/scit…
Tofaris Lab retweeted
This electronic chip may enable earlier prediction of Parkinson’s disease by detecting elevated levels of alpha-synuclein in the blood.
Learn more in @ScienceAdvances: scim.ag/4xVkDAo
Tofaris Lab retweeted
Delighted to share our latest paper @ScienceAdvances with @InalSahika: Electronic profiling of serum neuronal extracellular vesicles by amplifying and resolving multiple α-Syn proteoforms enables early prediction of Parkinson’s disease. science.org/doi/10.1126/scia…
Don’t miss Prof @GeorgeTofaris talk on Parkinson’s and EVs at the upcoming UKEV Early Career Researcher Virtual Event! 🧠🔬
Organised by our postdoc Dr Rahul Sanwlani.
Call for abstracts is open!
📅 28 Oct at 13h UK time | 💻 Online & free
🔗 ukev.org.uk
@NDCNOxford
Tofaris Lab retweeted
Here is a lay summary of our recent work on how α-synuclein damages neurons in Parkinson’s disease, and how we reversed these cellular defects.
ox.ac.uk/news/2026-08-06-oxf…
Many thanks to @UniofOxford for highlighting the study.
Tofaris Lab retweeted
New research from @GeorgeTofaris & collaborators "offers a unifying mechanistic link between α-synuclein pathology & dysregulation of diverse organelle-associated proteins that are both Sec61A translocon substrates & genetic modifiers of #Parkinsons" risk
nature.com/articles/s41467-0…
Tofaris Lab retweeted
Thrilled to share our latest paper! We show that early α-synuclein toxicity in human neurons is mediated by impaired ER co-translational protein translocation, providing a unifying mechanism underlying diverse genetic modifiers in #Parkinson's nature.com/articles/s41467-0…
Tofaris Lab retweeted
Many congratulations to our talented #DPhil student
@Gordon_Lam97 @TofarisLab @KavliOxford @NDCNOxford who received an award from the Henry Lester Trust for his studies using iPSC-based models of #Parkinson's disease. Well done! Keep an eye out for his paper!
Thanks so much to @OxNeurosci for organising such a fantastic day for the neuroscience community last week at @UniofOxford!
Our Master’s student, Emilia Hogg, had the opportunity to present her project and engage with the community, a great experience all around 🧠✨
@NDCNOxford
🎉We are happy to welcome Emilia Hogg for her Master's project.
@NDCNOxford @KavliOxford
"As part of my Master’s in Clinical and Therapeutic Neuroscience, I am joining the lab to study ⍺-synuclein aggregation and degradation.
Tofaris Lab retweeted
Many congratulations to @ShijunVictorYan who has transitioned from a very successful DPhil @TofarisLab @NDCNOxford @KavliOxford directly to Distinguished Investigator at Zhejiang University. An outstanding achievement. He is the 4th @TofarisLab alumnus to become Assistant Prof!
