. @timothyspringer sharing his inspirations and journey to science. #gairdner2019

Our latest in @eLife: Fusion surface structure, function, and dynamics of gamete fusogen HAP2: timothyspringer.org/publicat…

We used iPalm and a constrained photoactivatable fluorescent protein fused to lymphocyte function-associated 1 (LFA-1) to measure integrin extension on the cell surface: cell.com/cell-reports/fullte… in @CellReports

We propose that integrins bind ligand in their low-affinity state, which has a wider ligand-binding pocket, and then convert to their high-affinity state, which has a tighter pocket. pnas.org/content/early/2018/… in #PNAS @PNASNews

Our latest @embojournal paper on the activation of GDF8/#myostatin in collaboration with @ScholarRock and @jrengen lab: "Tolloid cleavage activates latent GDF8 by priming the pro‐complex for dissociation" emboj.embopress.org/content/…

Alignment of integrins (red is more aligned) during migration of a Jurkat T cell. Video taken at @mblscience youtu.be/c1mZTksVWps

"Prodomain-Growth Factor Swapping in the Structure of pro-TGF-β1" in @jbiolchem - timothyspringer.org/publicat…

Flow-induced elongation of von Willebrand factor precedes tension-dependent activation in @NatureComms - timothyspringer.org/publicat…

Watch Von Willebrand Factor, Jedi Knight of the bloodstream, feel the #Force. From our new paper in @NatureComms vector.childrenshospital.org…

Our latest in #PNAS @PNASNews - "Atypical interactions of integrin αVβ8 with pro-TGF-β1" timothyspringer.org/publicat…