My son brings out the best in me. We went deep on a variety of topics. Great fun. vimeo.com/1229335995/3d03448…

What if treating mental health didn’t mean taking a pill every day for the rest of your life? We invested in Eywa Biotech because they are building for a different future. Moving mental healthcare from chronic daily medication toward medicines that can create meaningful, lasting change with one or a few treatments. Now they are taking orders for their first GMP psilocybin capsules in 25mg, 5mg and placebo. They are being produced for clinical trials and research, and for regulated and emerging markets including Australia, the Czech Republic and Switzerland. Researchers, clinics and pharmaceutical companies interested in working with Eywa can reach [email protected] or [email protected]. And they’re not stopping there. Victoria Costa Paz and her team are using synthetic biology to make these medicines more accessible and scalable.

I listed my island in Tanzania for sale and the offers started rolling in. Gold mines, houses, cows. One gentleman offered $1 with a promise to pay the rest when he could. I admire the creativity. The @NewYorkPost wrote the whole thing up. Lupita started as a wacky idea after a family safari in 2004. Building a resort on an uninhabited island accessible only by boat sounded like a terrible plan. It turned out to be one of the great joys of my life. We just do not use it enough anymore. $7.9 million or best offer. The cows are still under consideration.

Back in April, I wrote about one of our newer portfolio companies, HexemBio, and their idea that reframed aging for me: people don’t die of old age, they die of aging blood. As blood stem cells decline, immunity weakens and disease follows. We invested because they rejuvenate a patient’s own cells instead of reprogramming them. Now they’re unveiling a three-generation product line off of their core technology. The transplant therapy program, an injectable, and a skin and wound product. That’s all that you can hope for when you back foundational science. You invest in one massive idea that turns into several products that can change the face of healthcare, because the underlying insight is so strong. Congratulations to Gabriel Levesque Tremblay and team. We’re looking forward to what’s coming next!

@PoseidonAero just closed a $60M Series A to build autonomous cargo planes from the ground up. Autonomous aircraft carrying cargo sounds wacky to some people today. So did an electric car company. So did internet phone calls. So did digital money. Every big idea I have ever backed went through the phase where the consensus called it impossible, and the entrepreneur saw beyond that. Air logistics is a massive industry running on decades-old assumptions: pilots in every cockpit, planes designed around a crew. Remove those assumptions and you get to rethink the entire aircraft. That is exactly the kind of rethink I look for, a team that does not want to just improve the existing model but replace it. The Poseidon team is building for a world the incumbents cannot see yet. Congratulations on the round.

I have a t-shirt that says Decentralize Everything. That is 40 years of observation compressed into two words, and I finally wrote the argument down as the first guest contributor to @CryptoniteRap. The piece is about DeSci, decentralized science. Every institution stagnates the same way. A small group ends up controlling the agenda, that group gets invested in the current framework, and challenging the consensus becomes a career risk. I have watched it in banking, telecom, rocketry, and now science. After 40 years I boiled it down to two rules. 1- The Draper Equation: the likelihood that a society needs to rethink an industry is proportional to the number of people benefiting from existing theories without change. 2- The Draper Corollary: the more centralized the decision-making, the less innovation occurs. The more decentralized the operations, the more innovation occurs and the faster that sector grows. The consensus mocked Hotmail, Skype, Tesla, Bitcoin, and SpaceX too. Every time, mockery was an excellent signal. Read the full editorial: cryptoniteventures.substack.…

An idea is like a keepsake. Hide it, and you forget where it was. Spread it to the world, and it grows more interesting and valuable. Every time I give away one idea, I seem to get three more. Don't worry about who gets the credit. Just move the technological ball forward.

Five years ago, the @RadiantNuclear team was pitching portable nuclear reactors. Today the US Army handed them a $750 million contract for 15 of them. We and @BoostVC were early investors and co-led their Series D recently. The founders made our decision to invest easy. They were determined to bring nuclear power back after decades of fear had frozen the field, and they kept building until the Army agreed. Missionaries, every one of them. Congratulations to the whole Radiant team. You earned every bit of this.

Californians: Steve Hilton on Joe Rogan. Great guy. I think the D’s may switch to R for this race. youtube.com/watch?v=BYVQfLi6…