https://xitter.cf/t.co/U1upUNHVM6 Structural Biologists at the University of Cincinnati
Cincinnati, OH
Joined April 2019
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Dear colleagues, friends, and followers!📢
We’re excited to share that all updates on our latest scientific achievements and lab activities will now be posted on our Bluesky profile.🦋 Follow us to stay in the loop! 🧫🧪⬇️
bsky.app/profile/thompsonlab…
"What if, instead of dreaming to marry a prince, she could dream about creating a vaccine, winning an Olympic medal or walking on Mars?"
— Goodnight Stories for Rebel Girls
Happy International Day of Women and Girls in Science! 👩🔬💪
TT lab's holiday party: from goofy gifts to heartfelt memories!🎄🎉The Xtals Awards reminded us of our incredible year together – challenges, victories, lessons learned, and everything in between. Here’s to a fabulous 2025!✨#LabLife #HolidayVibes
The TT Lab Olympics is behind us, and the entire lab had an amazing time competing, learning and supporting each other. A special congratulations to this year's champion, Drew Howard, for an outstanding performance!🏅 Looking forward to next year! #TeamBuilding 💪 #ScienceFun 🧪
Tom Thompson Lab retweeted
New session alert!
"BMPs in reproduction" in the 2nd Virtual BMP Forum chaired by Petra Knaus.
Speakers are Tom Thompson @ThompsonLab3 and Dan Bernards @BetaglycanDan.
When? Oct 9th at 3 pm CET.
Please share and sign up 👇
docs.google.com/forms/d/1_Jf…
🗓️ Save the date: Oct 13-16, 2024!
SEBM Council organizes the Experimental Biology & Medicine Conference in Kissimmee, FL!
The EBMC is an interdisciplinary event bringing together established scientists and trainees.📚
👉Register here: exbiomedcon.org
ALT Nate's poster "Functional and Structural Studies of Anti-Müllerian Hormone Prodomain Cysteine Architecture"
ALT Lucija's poster "Structural comparison of Activin subclass ligands in complex with Fst288"
ALT Muhasin's flash talk "A Novel Approach to Study Mechanism of Heterodimerization of TGFβ Ligands"
ALT Ryan's short talk "Low Blood Levels of Subforms of GDF11/8 Predict Higher Risk of Incident Cardiovascular, Dementia, and Mortality Events"
A truly inspiring experience! #TGFSRC
We had a valuable opportunity to dive into the latest advancements in the field, learn from cutting-edge discussions and connect with brilliant scientists from academia and industry. We came back full of energy and new ideas!💡🧪🧫
Our lab presented six poster presentations and gave three oral presentations showcasing our latest work. 😎💪
Above all, we were delighted that Drew Howard won first award for best short talk and Jacob Mast won second prize for best poster presentation. 🏆👏🔝
ALT Tom's talk "Structural diversity of TGF-β signaling"
ALT Drew's short talk "Structural Basis of Non-Latent Signaling by the Anti-Müllerian Hormone Procomplex"
ALT Jacob's poster "Characterization of the Molecular Mechanism of Erythroferrone Antagonism and Specificity"
What an amazing week behind TTlab! 🎉
From July 21 until July 25, we participated at the FASEB TGF-β Superfamily conference held in Niagara Falls, NY. 🌊
#TGFSRC
Our graduate student, Jacob Mast, received funding from the American Heart Association for his research and was awarded for excellence by the UC Department of Molecular & Cellular Biosciences 👏🧫🧪🔝
Dr. Thompson was invited to participate in the Nobel symposium 'TGF-β Family: Future Frontiers in Medicine and Physiology' that took place at Bergendal, Sweden 🇸🇪, from the 27th to the 30th of May. 👏
In summary, our research into AMH's non-latent signaling offers groundbreaking insights into its structure, function, and evolutionary history, laying the groundwork for future therapeutic developments.
Many thanks to the lab and to our collaborators in Boston! 10/10
Our study sheds light on AMH's signaling mechanism, revealing how the prodomain's unique structure facilitates receptor interaction without inducing latency, offering a novel perspective on the mechanism. ✨9/10
Mapping specific mutations within the AMH prodomain highlights their impact on signaling. Our research connects these mutations to disorders like PMDS and PCOS, emphasizing the prodomain's significance in these conditions. 8/10
The helical bundle domain of the AMH prodomain, pivotal for its function, emerged from an exonic insertion approximately 450 million years ago. This evolutionary innovation has been crucial for AMH's signaling ability. 🕰🧬 7/10
