Lecturer in Neuroscience and Translational Research Fellow interested in how disease risk affects microglial activation states #AD #iPSC #Epigenome

Exeter, England
Joined September 2010
Excited by microglia, drug discovery and the power of stem cell models? Come to beautiful Devon for a fully funded PhD with myself and @PsyEpigenetics. @ExeterBRC @uniofexeHLS @ExeterMed @ExeterNeuro. Application deadline 24th June 2024: exeter.ac.uk/study/funding/a…
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Excited to start as Emerging Leader at @UKDRI and continue to study cellular crosstalk in neurodegeneration
We're delighted to announce 3 new UK DRI Emerging Leaders: @M_Malpetti, @AnnaMallach, & @val_jaramillo! 🎉 🙌 👏 The initiative supports exceptional ECRs on their journey to setting up an independent lab. Find out more about our new Emerging Leaders👉buff.ly/47lcA4a
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No, not 💯 Elon. In the U.K. they’re not going round ‘finding people who’ve said something they disagree with and putting them in a f—king cage.’ Some people are being charged for inciting racial hatred and for organising acts of violence. It’s very specific, and it’s the law in most democracies including the US. For example, one person has pleaded guilty today to inciting an attack on a hotel housing asylum seekers: an attack which then took place. Another hotel was set on fire, with people still inside. Freedom carries responsibility: and freedom of speech carries with it the responsibility of each of us to use our words wisely and to be aware of the damage misinformation can cause. To be clear, criminal violence directed towards various communities in the U.K. was perpetrated as a result of malicious and specifically targeted misinformation online. And it’s a relief no-one was killed. Words matter. And yet here you are, running a huge information network, and all you can do is post 💯 over something you choose not to verify for accuracy, not alert people to it’s highly damaging nature. In fact, because of who you are, your 💯 gives it a stamp of approval in the eyes of those who seek validation for their actions. What we say and do has real consequences. That’s because we’re not in a matrix, we’re in real life, and sticking 💯 on a lie doesn’t turn it into truth.
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Dr @Thomaspiers at the @UniofExeter is developing a brain organoid model containing human neurons and microglia (the immune cells of the brain) to study the early stages of Alzheimer’s disease. #kinderscience #dementiaresearch #alzheimersdisease
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Really excited about the opportunity to direct the UK Human Functional Genomics Initiative! Please do get in touch if you are interested in learning more about our plans and joining the community forms.office.com/e/VYxHLKLQ3… @UniofExeter @UKRI_News @The_MRC
We’re funding four research clusters and welcoming Director Prof Jonathan Mill @UniofExeter to lead the Human Functional Genomics Initiative. The £28.5m initiative will advance our understanding of how genomic variation influences human physiology: orlo.uk/hamNy @BBSRC
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Thomas Piers retweeted
TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism biorxiv.org/content/10.1101/…
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I have an exciting PhD position available to join my lab starting this October at the @UKDRI . If you are interested in understanding how microglia contribute to Parkinson's disease and want to study cellular interactions using different methods, apply! findaphd.com/phds/project/th…
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Positive Ultra-bright Fluorescent Fusion For Identifying Neighbours (PUFFFIN) allows visualization and isolation of surrounding cells in culture, tissues, or embryos, for profiling non-cell-autonomous responses @_CellySally_ et al embopress.org/doi/full/10.10…
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What an evening in North Cornwall😀. Imagine working somewhere with this on your doorstep. @uniofexeHLS currently recruiting for genomics and data science faculty posts. jobs.exeter.ac.uk/hrpr_webre…. Please RT.
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Last few days to apply for this exciting PhD studentship for those interested in human disease modelling using iPSC-derived organoids with @PsyEpigenetics and me. @ExeterBRC @uniofexeHLS @ExeterMed @ExeterNeuro Application deadline 24th June 2024: exeter.ac.uk/study/funding/a…
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We’re proud to launch the #DementiaCoalition Manifesto alongside our partners at @UKDRI, @alzheimerssoc, @DementiaUK & @alzscot. As our population ages, dementia will be the defining health challenge of our time. The next Government must act. alzheimersresearchuk.org/wp-…
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We have a funded 3.5 year PhD studentship exploring genomic mechanisms underlying resilient and susceptible neurons to tangle pathology in AD brain. Come work in the @Dementia_Omics team at @uniofexeHLS with myself, @Jenny_Imm and Adam Smith! Check it out: exeter.ac.uk/study/funding/a… – at South West, England
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Thomas Piers retweeted
It is so exciting to see my postdoc paper (finally) out! cell.com/cell-reports/fullte… Here we tested novel spatial transcriptomics platforms to investigate how cells interact in a model of Alzheimer's disease. We found... 1/n
Researchers at the UK DRI, @TheCrick & @CBD_VIB led by @AnnaMallach & @Arancibia_Lor have found that communication between support cells in the brain is closely linked to Alzheimer’s in mice🧠 The findings could lead to new therapeutic targets👉buff.ly/459UtNw
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Thomas Piers retweeted
Super exciting to see my paper so widely discussed at the @TheCrick - it was great working with the core facilities to get early access to these incredible technologies
Researchers at the Crick, @UKDRI and @CBD_VIB have found that chatter between support cells in the brain is closely linked to Alzheimer’s disease in mice. The findings open up potential research avenues in the search for new Alzheimer’s treatments. crick.ac.uk/news-and-reports…
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Thomas Piers retweeted
Microglia-astrocyte crosstalk in the amyloid plaque niche of an Alzheimer’s disease mouse model, as revealed by spatial transcriptomics: @CellReports cell.com/cell-reports/fullte…
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"Hi Rishi, it's Michelle from Mone Military Uniforms."
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