Upon its introduction, glyphosate was heralded as a "silver bullet" for weed control. Likewise, glyphosate-resistant crops came with the lofty claim that they would greatly reduce applications of herbicides. Instead, glyphosate applications increased 10x on US cropland within the first 4 years of glyphosate-resistant commercialization. Its sustained overuse has led to the development of over 350 glyphosate-resistant 'super-weeds,' which cause an estimated $43 billion in crop damage each year. Silver bullet approaches do not work in agriculture, no matter how shiny and promising. More often than not they create more problems than they solve.