@ThiriLin3

Pathologist #Dermpath #Breastpath #GIpath

Joined October 2020
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CD30⁺ lymphomas: from biology → diagnosis → therapy 🎯 CD30 is not a diagnosis. It’s a shared activation marker across distinct lymphomas. 🧬 EBV can be + in BOTH: • Hodgkin lymphoma • DLBCL So CD30⁺ + EBV⁺ ≠ one disease. 👉 Diagnosis requires: • Morphology • Immunophenotype (CD20 / CD15) • Clinical context (mediastinum?) ⚠️ The risk: Misclassification → wrong therapy 💊 Why this matters: CD30 is targetable → Brentuximab vedotin (including FDA-approved R² combination in R/R DLBCL) 💡 Take-home: Same marker ≠ same disease ≠ same treatment CD30 is a bridge—not a diagnosis. #lymphoma #Hemetwitter
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Endometrial metaplasias: - Myomatous stromal metaplasia Desmin stain (Pic 2) Incidental finding #everydayGYN #pathology #PathX
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Testicular tumor in a young boy. What's your diagnosis? #GUPath #PathTwitter #Crittersontwitter
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Weekend treat 🍬 C L A S S I C 🏛️ Organ? diagnosis ? 🤔 #Pathology #Endocrine #PathTwitter #PathX
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#TooCloseToDiagnose? 🧐 A. Myrmecia B. Epidermodysplasia verruciformis C. Paget's disease D. Verruca vulgaris #Pathology #Dermatology #Dermatopathology #DermPath
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ARCHITECTURAL PATTERNS:Cutaneous Spindle Cell Neoplasms. Idea:APLM2018;142:958-972 #dermpath #bstpath #surgpath #pathology #pathologists @JMGardnerMD @JMcMahonG @histiocytosisX @DrFNA @GeronimoJrLapac @BinXu16 @jaimearturomc @VijayPatho @mreyesm @Alipathy
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Bladder Plasmacytoid Urothelial Carcinoma Pitfall ⚠️: It can stain CD138 positive (CD138 can stain epithelium). Run a panel of IHC (pic 2). Plasmacytoid histology can be seen in different neoplasms (see pic 3). Dr. Magi-Galluzzi – 2025 Diagnostic Pathologic Update #USCAP #pathology #PathX
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Diagnosis of metastatic prostatic carcinoma - IHC Dr. Magi-Galluzzi - 2025 Diagnostic Pathologic Update #USCAP #pathology #PathX
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GATA3 IHC is useful but you need to be aware of the pitfalls... Dr. Magi-Galluzzi - 2025 Diagnostic Pathologic Update #USCAP #pathology #PathX
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Stunning contrast between flat urothelial carcinoma in situ (right side of each image) and reactive urothelium (left side) CIS➡️enlarged, irregular, & hyperchromatic nuclei Reactive➡️small, uniform nuclei w/vesicular chromatin + intraepithelial acute & chronic inflammation
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Vulva - Cutaneous syphilis - Condyloma lata - Epithelial hyperplasia (Pic 1) - Plasma cell infiltrate with scattered macrophages and lymphocytes (Pic 2) - Spirochete IHC stain (Pic 3) #everydayGYN #PathTwitter #pathology #PathX
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Juvenile Polyp ✔️Most common polyp in children ✔️More than 1/2 in the rectosigmoid colon ✔️Can be sporadic or syndromic (JPS) ✔️SMAD4/BMPR1A mutations ~ 50% of JPS families ✔️Histologically identical polyps can be seen in other hamartomatous polyposis syndromes #PediPath #GIpath
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Breast-When evaluating possible ADH or DCIS involving a papilloma: - Look for areas of pure epithelial proliferation with few fibrovascular cores. - Examine the duct wall or neighboring glands outside the papilloma; if involved by DCIS or ADH, compare their morphology to the proliferation that inside the papilloma to make the diagnosis. - Papilloma involved by ADH: <3 mm. - Papilloma involved by DCIS: ≥3 mm. - Pitfall: Myoepithelial markers are not reliable for distinguishing papilloma with UDH from those with ADH or DCIS (papillomas with ADH and DCIS can retain myoepithelial cells). Dr. Lerwill - 46th Annual Current Concepts in Surgical Pathology #pathology #PathX #Pathtwitter
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Spam Email: Can you spot the difference?
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Dr. Sarah Dry has published a wonderful review of fatty tumors and nerve sheath tumors. Check out this malignant triton tumor (malignant peripheral nerve sheath tumor with rhabdomyosarcomatous differentiation) - the muscle differentiation is obvious on H&E. Dry S. Updates in Peripheral Nerve Sheath and Adipocytic Tumors. Mod Pathol. 2025 Nov 1;39(1):100929. PMID: 41183597.
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Endoscopic surprise → histologic answer: Amyloid deposition in the stomach, it mimicked GAVE on endoscopy. Congo red tells the story.
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This adrenal cortical carcinoma presented as a liver mass. The CK8/18 highlights a tiny rim of compressed liver at the periphery. On a prior needle biopsy it was a mimicker of hepatocellular carcinoma but we figured it out thanks to modern immunohistochemistry.
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You're called early morning on a Sunday. Patient with anemia, abdominal pain and history of heavy drinking. Diagnosis?
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Airdrying artifact rendering a "pseudo-keratinized" appearance in this "Anaplastic Thyroid Carcinoma" on Pap stain. (FNA)
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Breast, 60y #pathology #patologia #pathoutpic #breastpath #breastpathology
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