@TheWendeLab

Research lab at @UABHeersink studying epigenetics, metabolism and heart disease

 Birmingham, AL
sites.uab.edu/wendelab/
Joined August 2022
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  • Followers173
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The latest collaboration with @AdamWende @TheWendeLab identifying “O‐GlcNAc memory” as a component of metabolic memory in the heart including @SamuelFChang & @CardioMyocyteHa plus many others. @UABPathology @UABHeersink @AHAScience @NIH #NHLBI #GlcNAc ahajournals.org/doi/10.1161/…

Transient Increase in Cardiomyocyte Protein O‐GlcNAcylation Enhances Susceptibility to Pressure...

ahajournals.org
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Meet Mahima Reddy, a Ph.D. candidate in the @AdamWende Lab in @UABPathology. Her research focuses on O-GlcNAc-driven cardiac remodeling, which is similar to the cardiac pathology seen in diabetes-related heart failure. Read more: go.uab.edu/ucdcmahimareddy
Mahima Reddy

ALT Mahima Reddy

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AHA-supported undergraduates presenting their research work at BCVS. @AHAScience @BCVSearlyCareer @HonorsUAB @UABCardiology @AdamWende
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Happy to report we have published a new study on "O-GlcNAc Memory". We hope that the findings will provide insight into the mechanism behind increased susceptibility to heart failure in patients with diabetes. ahajournals.org/doi/10.1161/…

Transient Increase in Cardiomyocyte Protein O‐GlcNAcylation Enhances Susceptibility to Pressure...

ahajournals.org
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Replying to @MahimaReddy11
@MahimaReddy11 represents @TheWendeLab at 2026 Cardiac Regulatory Mechanisms Gordon Research Conference & Seminar
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@MahimaReddy11, a rising GS-3 in the @TheWendeLab presented posters on the lab's latest O-GlcNAc work at the 2026 Cardiac Regulatory Mechanisms Gordon Research Conference (GRC) and Seminar (GRS) in New London, New Hampshire.
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@MahimaReddy11 was also invited by the GRS to serve as the Discussion Leader for the early‑career researcher session, “Utilizing Omics and Large Data to Understand Cardiac Physiological and Pathological Mechanisms.”
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This month we get to know Md Saimoon Rahman, a 3rd year graduate student in the laboratory of Adam R. Wende, Ph.D. in @UABPathology. Read more about Rahman here: bit.ly/4duYd0x @TheWendeLab @AdamWende @Saimoon_Rahman
Md Saimoon Rahman

ALT Md Saimoon Rahman

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Excited about our new publication in Epigenetics defining a model to test glycemic memory and the potential role of glucose as a signaling molecule to lead to sustained susceptibility to exacerbated remodeling in response to subsequent pressure overload. tandfonline.com/doi/10.1080/…
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Cardiac ageing & #HFpEF⏳ Explore cellular, structural & functional changes with #cardiac ageing & #heartfailure with preserved ejection fraction in this #CardiovascularResearch Spotlight Review ow.ly/9GOL50WWNKf @CVR_TomaszGuzik @glenpyle @DrMikeDrozd @Sarah_KBrown #CVD
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🚨 Save the Date! UAB Cardiology presents the 12th Annual CCVC Symposium:"Revolutionizing Cardiovascular Medicine: Innovations in Human Disease Modeling & Therapeutics" 📅 October 9–10, 2025 🔗 Register Here: go.uab.edu/3GbVr3G
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Wende Lab retweeted
JAHA@JAHA_AHA
9 Jul 2025
From 1970 to 2022 in the U.S. mortality for myocardial infarction⬇️89%, ischemic heart disease⬇️81%, while other heart disease, including heart failure,⬆️81%. #AHAJournals ahajrnls.org/4kou30t
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Latest collaboration between Martin Young's @JohnCChatham and @AdamWende lab focused on role of cardiomyocyte O-GlcNAc on circadian clock regulation. Full text coming soon! frontiersin.org/journals/car…

Frontiers | Severe attenuation of circadian clock output in the heart following sustained augment...

BackgroundChanges in circadian-related behaviors (e.g., the timing of food intake, sleep cycles) and the environment (e.g., light-dark cycles) increase the r...

frontiersin.org
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We’re excited to share that Samuel F. Chang successfully defended his PhD on June 2, 2025! His dissertation explored how cardiac O-GlcNAcylation links diabetes to heart disease. Congrats, Dr. Chang on this remarkable achievement! @UABPathology @TheWendeLab @UAB_GBS
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PhD✅ MD …loading… 6 years after starting my physician scientist journey, reached the big milestone of finishing my PhD!! 🎉Couldn’t have done it without the endless support of @AdamWende @TheWendeLab @UABMSTP @UABExerciseMed @UABPathology 🔬🩺
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UAB at ISHR 2025: Fantastic science, amazing friends, beautiful location! @UABHeersink @UABPathology @UABCardiology @TheWendeLab
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🎉 @AdamWende, Ph.D., associate professor in the Department of Pathology’s Division of Molecular and Cellular Pathology, has been awarded the senior faculty 2025 @UABHeersink Dean’s Excellence Award in Mentorship. Congratulations, Dr. Wende! Read more: bit.ly/3GMsIlU
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@TheWendeLab trainees @Saimoon_Rahman @MahimaReddy11 presented their innovative research at the 16th Annual Boshell Research Day @AuburnU, focusing on our commitment to advancing knowledge in cardiovascular and metabolic disease.
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Been awhile since I've logged in but have great reason to this week. SHVM 2025 Registration is now open! If you are passionate about cardiovascular metabolism this is a must attend meeting. This year in Bordeaux, France. More details here: shvm2025.azuleon.org/welcome
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@UABPathology recently funded travel awards to three trainees, @Md_Ali_Akkas, Dr. Nicole Arroyo-Diaz and @SamuelFChang, who presented their research at national meetings. @DarioVitturi @danis1337 @AdamWende Learn more about their presentations here: bit.ly/3ZvoO6M
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