Lisbon, Portugal
Joined March 2015
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Open position for a research assistant/PhD student to work in metabolic and transcriptional regulation of stem cells in Drosophila! Check out more at euraxess.pt/jobs/295466
Catarina Homem retweeted
#DBfeature #Drosophila🪰
Opposing effects of ecdysone signaling regulate neuroblast proliferation to ensure coordination of brain and organism development
by Andreia Oliveira, Catarina Homem @TheHomemLab
sciencedirect.com/science/ar…
In our latest article we demonstrate that Drosophila brain development is under the coordination of the hormone ecdysone. We show that neuroblasts have an intrinsic capacity to proliferate indefinitely and require ecdysone signalling to determine cell cycle pace!
Do you know how animals coordinate the growth of their different organs during development? Systemic signals such as hormones coordinate the development of all organs and direct tissue specific developmental programs.
Catarina Homem retweeted
Happy #FluorescenceFriday! Eunice Silva, @margarida_venda & @TheHomemLab find that serine hydroxymethyl transferase is required for optic lobe neuroepithelia development in Drosophila.
📖@Dev_Journal: journals.biologists.com/dev/…
#DevSImetabolism
Catarina Homem retweeted
Serine hydroxymethyl transferase is required for optic lobe neuroepithelia development in Drosophila
An #OpenAccess Research Article in our Stem Cells and Regeneration section of #DevSImetabolism by Eunice Silva, @margarida_venda & @TheHomemLab
journals.biologists.com/dev/…
According to our model, the onset of translation is delayed in order to regulate neuronal maturation.
Learn more by checking the link in our bio!
In our brand-new article in @PLOSBiology we use Drosophila to show that the transcription and translation of neurotransmitter-associated genes is timely coordinated with the animal’s development.
Did you know that there are different phases of neuron maturation?
From the time a neuron is born until it is capable of forming synapses there are different sets of genes that need to be cordinately expressed.
Our latest article is out ! read it here👇
journals.plos.org/plosbiolog…
Catarina Homem retweeted
Within hours of #neuron birth, terminal differentiation genes are transcribed, but not translated. In #PLOSBiology, @TheHomemLab reveals that these transcripts are only translated days later in a way that coordinates with developmental stage in #Drosophila
plos.io/3IzWad5
ALT A fluorescence microscopy image showing VGlut expression in the optic lobe of a wild-type Drosophila larva at 48h after puparium formation. Credit: Graça S. Marques
Our postdoc Ana just signed her CEEC contract, granting her funds to pursue her scientific work for the next 6 years! Congrats ! @nova_medschool @fct_pt @NOVAunl
These defects are similar to the defects that are observed when neural tube closure defects occur in human fetuses, and sets important foundations to understand how folic acid works during brain formation.
In our recent article in @Dev_journal, using fruit flies as a model, we show that during brain development, neuroepithelia cells with impaired folic acid metabolism have higher death rates, fail to form furrows and ultimately generate less neurons.
Did you know that even though pregnant people take folic acid to avoid neural tube defects in babies, as spina bifida, little is known about what it does?
Check-out our new paper! Serine hydroxymethyl transferase (Shmt) is required for optic lobe neuroepithelia development in Drosophila.
tinyurl.com/2rwmrrm8
Interestingly, we show that the oncogene dMyc is involved in the upregulation of these transporters, highlighting the important link between oncogenes and metabolic transporters in the regulation of tumor growth.
In this study we show that some plasma membrane metabolic transporters are crucial for brain tumor growth in Drosophila. Among these transporters, we identify the heterodimeric amino acid subunits CD98hc and several of its light chains as potent mediators of tumor progression.
Check out our newest open-access paper on dMyc-dependent upregulation of heterodimeric amino acid transporters and their role in Drosophila brain tumor growth!
link.springer.com/article/10…
