The Holley Lab at Duke University works to discover how non-coding RNAs and epitranscriptomic RNA modifications contribute to heart disease.
Durham, NC
Joined July 2019
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Holley Lab retweeted
While the indirect rates have in general been to high, it reflects that the direct costs have not been inflation-adjusted for decades. If you do this, put the money back into direct costs that actually fund the research. This is a total disaster for all universities.
Holley Lab retweeted
NIH just made a drastic change to indirect cost rates, reducing the rate to 15%, a significant cut from the 60%+ some institutions charge. This will have a devastating effect on the nation’s medical research infrastructure. @ResearchAmerica @AAMC @YaleMed grants.nih.gov/grants/guide/…
Holley Lab retweeted
NIH indirect costs fund the backbone of research: maintaining labs, ensuring safety, and supporting admin work. These are essential for groundbreaking discoveries. Drastic cuts to NIH indirect rates are detrimental to academic biomedical research.
Holley Lab retweeted
NIH has announced a cut in the "indirect rate" to 15% across the board, in a move that appears to be retroactive to even existing grants. This is a bloodbath for research institutions throughout the country.
Brief explainer for those not in this world:
buff.ly/3EtML7D
Holley Lab retweeted
This approach to suddenly cutting @NIH grant indirect costs will cause chaos and harm biomedical research and researchers in hospitals, schools and institutes nationwide. A sane government would never do this.
Last year, $9B of the $35B that the National Institutes of Health (NIH) granted for research was used for administrative overhead, what is known as “indirect costs.” Today, NIH lowered the maximum indirect cost rate research institutions can charge the government to 15%, above what many major foundations allow and much lower than the 60%+ that some institutions charge the government today. This change will save more than $4B a year effective immediately.
Holley Lab retweeted
The NIH 15% cap on indirect costs will kneecap biomedical research in the US.
Without essential infrastructure, there will be:
Staff cuts
Lab closures
Fewer research projects
Less scientific progress
Loss of talent
The US will no longer lead scientific & medical innovation.
Holley Lab retweeted
Attention prospective postdocs: Are you interested in studying RNA modifications and using cutting edge technologies to uncover the role of m6A in physiology and disease? Come join our team! We are hiring!
themeyerlab.com
Holley Lab retweeted
Medical knowledge is doubling every 60 days.
There are no shortcuts for training physicians.
MEDICINE IS DIFFICULT AND SERIOUS BUSINESS. 👇🏼👇🏼
Holley Lab retweeted
BREAKING NEWS
The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.
Holley Lab retweeted
Great visualization and a nice way for trainees to see what it takes to make it as an academic scientist. 👍👍👍🙏🙏🙏👏👏👏
Here’s a timeline of my career
Orange=grants submitted
Green=grants funded
Lessons learned?
-persistence pays
-scientist=professional writer
-grant writing makes the science better
-scientist=entrepreneur. Not every “invention” is a hit (learned this from @ABCSharkTank)
Holley Lab retweeted
Excited to share our latest work developing DART transgenic mice and using them to profile m6A in single cells of the mouse brain. A fantastic study led by Matt Tegowski with contributions from @TheHolleyLab nature.com/articles/s41593-0…
Holley Lab retweeted
Are you an MD student interested in research?
Would strongly consider applying for the @SarnoffCardio Fellowship. Scientific immersion with *unparalleled* longitudinal mentorship & exceptional peer network career-long. sarnofffellowship.com/
My biggest regret in med school was not participating despite guidance from mentors. Now I'm thrilled to join this vibrant community on the Scientific Committee.
Nice summary of the program ahajournals.org/doi/10.1161/… @CircAHA
Track record of successful physician-scientists going through this program is impressive - the recipe of immersion + longitudinal engagement/sponsorship/mentorship works very well
Holley Lab retweeted
RNA science has gone mainstream - learn from outreach experts how to best explain your research in a way that the public actually understands!
Join us for the Public Engagement in RNA Research Workshop scheduled just prior to RNA 2024 in Edinburgh. Registration required and the deadline for joining is tomorrow, May 16th!
tfaforms.com/5125400
Holley Lab retweeted
Learned so much from @KatherineZhouMD and @TheHolleyLab putting this together
Keep an eye out for Katherine, she's a fantastic scientist!
More to come soon 🧐 @RNADiscovery @UNC_Lineberger @chrisholley
New methods for high-throughput Nm mapping have been developed in recent years, but challenges remain in accurate mapping and manipulation of Nm to understand its function and disease relevance #RNA
#RNAmods bit.ly/4aUERje
Holley Lab retweeted
Most viewed in the last 7 days from @JAMA_current:
New USPSTF guidelines recommends all women undergo routine #breastcancer screening every other year beginning at age 40, an update from the 2016 recommendation to start at age 50.
ja.ma/3JLTmtr
Exciting work with translational promise from the Holley and Freedman labs, presented at #AHA23 by Brittany Elliott, PhD:
Holley Lab retweeted
Manesh Patel followed his dream of making a difference, and to him, it’s a privilege. #AwardsWithHeart Read his full story: spr.ly/6013OMw0t @manesh_patelMD @AmericanHeartNC
Holley Lab retweeted
Duke is proud to be recognized as the #1 program in the U.S. for #hearttransplants in 2022, and the only program in the Southeast to transplant more than 1,800 heart and heart-lung transplants.
@DukeHeartCenter | @DukeCTSurgery
Holley Lab retweeted
Please RT: We are delighted to announce that the Department of Human Genetics at the University of Michigan has multiple positions for tenure-track faculty at the Assistant Professor level! Please apply here: tinyurl.com/xeuwtv5t