@TheFischerLab
 Memphis, TN
stjude.org/fischer
Joined September 2019
  • Tweets42
  • Following109
  • Followers235
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We're at it again, but even better! Please join us virtually or in person at St. Jude for 2023 Bringing Chemistry to Medicine! @StJudeResearch bit.ly/BC2M_2023

Bringing Chemistry to Medicine Symposium

The Bringing Chemistry to Medicine Symposium (Oct. 1-2, 2026) features thought leaders at the interface of chemical and biomedical sciences, working in areas spanning therapeutic regulation of...

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Like comparing apples to apples, comparing similar proteins can be challenging. Scientists in @TheFischerLab developed a tool to help, which garnered new insights into the chaperone protein HSP90—an essential target in cancer. Read about their work. bit.ly/3LMhQVf
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FLEXR uses Ringer-based electron-density sampling to build explicit multi-conformer models for refinement, capturing conformations in ligand-binding sites that were undetected using other methods. #CrystallographicRefinement #ModelBuilding doi.org/10.1107/S20597983230…
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Interested in water in ligand binding sites? Our newest paper applies RE-EDS to study the thermodynamics of water networks in protein cavities. pubs.acs.org/doi/10.1021/acs…

Accounting for Solvation Correlation Effects on the Thermodynamics of Water Networks in Protein...

Abstract. Macromolecular recognition and ligand binding are at the core of biological function and drug discovery efforts. Water molecules play a significa

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New research from @TheFischerLab published in the Journal of Medicinal Chemistry has revealed distinct targetable hotspots on #HSP90, an important target in cancer. bit.ly/3SRxpwt @ACSBioMed
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TheFischerLab retweeted
Behnam Nabet@behnamnabet11 Oct 2021
The Nabet lab @fredhutch is recruiting a highly motivated postdoc to join our supportive/collaborative team! Interested in developing targeted protein degradation technologies and advancing proximity-induced therapeutic strategies? Please RT & apply here: careers-fhcrc.icims.com/jobs…
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💥Enhanced sampling strikes again: we used aMD to see a buried apolar cavity open up to solvent, feeding this thermodynamic info to DOCK3.7 we saw some really cool new chemistry that also showed up in the beautiful crystals from Isha Singh 🎉🎉 #compchem #cadd @PNASNews
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🎉 Issue 34 is here! 🎉 Marcus Fischer (@TheFischerLab) et al.'s recent #ChemSciPicks article is featured on the front cover 😍 Read it here ➡️ Temperature artifacts in protein structures bias ligand-binding predictions 🔗 ow.ly/htjA50G2PSZ 📍 @UCIrvine | @StJudeResearch
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Scientists are exploring how temperature can change research on protein structures. ow.ly/20wq50FTu0r @ChemicalScience @TheFischerLab #ChemicalBiology
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🥳 It is delightful to work at a place that truly believes this, and backs it up with the $$$
St. Jude Research
@StJudeResearch28 Apr 2021
Fundamental lab-based research is the engine that drives most advances in medicine. Between 2022-2027, St. Jude will increase faculty members by 22 new hires; continue to invest in shared resources; expand data science; increase @stjudegraduate enrollment. stjude.org/strategic-plan
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Nicholls et al.: Modelling covalent linkages in CCP4 #CovalentLinkage #AceDRG #CCP4 ... #IUCr scripts.iucr.org/cgi-bin/pap…
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Nicholls et al.: The missing link: covalent linkages in structural models #CovalentLinkage #AceDRG #CCP4MonomerLibrary ... #IUCr scripts.iucr.org/cgi-bin/pap…
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TheFischerLab retweeted
Simon Olsson@smnlssn29 Apr 2021
I have an open position in my lab at @chalmersuniv (@cse_gbg) for a postdoc. If you are excited about applying and developing ML for science, then please apply by May 31st. #mljobs #postdoc chalmers.se/en/about-chalmer…
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TheFischerLab retweeted
London Lab@london_lab25 Mar 2021
Very proud of our new @J_A_C_S paper describing Covalent Ligand Directed Release Chemistry (CoLDR). Congratulations @reddi78 and team for adding a new electrophile modality to the arsenal. Twittorial below. 1/n pubs.acs.org/doi/full/10.102…

Tunable Methacrylamides for Covalent Ligand Directed Release Chemistry

Abstract. Targeted covalent inhibitors are an important class of drugs and chemical probes. However, relatively few electrophiles meet the criteria for suc

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Water can make all the difference when it comes to helping ensure a protein can do its job. ow.ly/cd9p50xgb74 @TheFischerLab #ligand
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Our guest of honor courtesy of Marcus Fischer, Brian Shoichet, was also here presenting his amazing work!
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