Professor at Iowa State University, Studying aging and autophagy, mitochondria, Peroxisome...

Ames, IA
Joined August 2011
New publication from the lab @pnas . With the collaboration of Dr. Ping Kang @pingkang0, we uncovered how developmental NF-kB signaling links developmental timing (time to maturity) to lifespan😊😊pnas.org/doi/10.1073/pnas.24…
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五脏最喜欢的中成药大全,为了自己和家人的健康,收藏起来吧!但药需要谨遵医嘱! 1、肝 肝气郁结——逍遥丸 肝火旺——牛黄解毒片 肝胆湿热——龙胆泻肝丸 肝血不足——四物汤 2、脾 脾气虚——参苓白术丸 脾阳虚——理中丸 脾虚生湿——香砂六君丸 痰湿困脾——健脾丸 3、肾 肾阳虚——右归丸 肾阴虚——右归丸 肾气虚——金锁固精丸 肾精亏虚——补肾益精丸 4、肺 肺阴虚——养阴清肺丸 肺气虚——人参保肺丸 肺气上逆——补中益气丸 肺气不足——玉屏风颗粒 5、心 心气虚——柏子养心丸 心阳虚——参附强心丸 心血虚——天王补心丹 心火亢盛——牛黄清心丸
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Had a patient recently come see me with Stage 4 metastatic colon cancer, at the young age of 37. The majority of his treatment and surgeries were completed at MD Anderson in Houston, often ranked among the top Cancer hospitals in the world. He sought me because his oncologist would not prescribe any ‘non-traditional’ medications like ivermectin, Fenbendazole, or Mebendazole. Before you jump to conclusions and start rambling about anti-parasitic, let’s talk about how each of these works in the body. Ivermectin works in cancer on WNT/TCF and PAK1→Akt/mTOR inhibition, mitochondrial respiratory suppression, chloride-driven hyperpolarization, and P2X4/P2X7-linked immunogenic cell death. Fenbendazole works for cancer by impacting mitochondrial translocation of p53 and inhibition of glucose uptake, GLUT transporter expression, and hexokinase II, on top of moderate microtubule destabilization. Mebendazole's main mechanisms regarding cancer are still β-tubulin binding, VEGFR2 inhibition, and Hedgehog inhibition. This in turn leads to reduced glutamine markers which have downstream effects. [Notice I didn’t say anything about parasites there. Feel free to show this tweet to someone who doesn’t know any better.] The oncologist actually supported their use but likely due to ‘politics’ couldn’t personally prescribe them. So instead of 1 doctor managing all of his cancer care, he has like 5. Unfortunate but becoming increasingly common. At the end of the care you have to be AN ADVOCATE for yourself. If you don’t like the answers you are getting (in medicine), continue to seek out providers until you do.
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I've been meaning to share these thoughts for a while and touched on them briefly in a recent conference talk. They are relevant to a lot of the discussions today.
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Hua Bai retweeted
一台治肩周炎的机器,被中国科学家发现能够清理阿尔茨海默病的斑块。 听着像骗局,但论文发在Science子刊,出自解放军301医院,用的只是一台乡镇卫生院照一次二十块钱的国产理疗机。 一台平时给人治腰腿疼的理疗仪,怎么管起了脑子里的事? 原来科学家发现,大脑平时得靠深睡时涌动的脑脊液,顺着血管周围把引发痴呆的垃圾冲走。 而这台机器隔着两厘米空气、用不发热的微弱功率照上十分钟,就能让清醒的小鼠脑电波跳出深睡才有的慢波,大白天开始给脑子大扫除。 痴呆小鼠连照七天,脑里的斑块真少了,停照一个月后记性还比没照的好。 要知道,现在患者用进口抗体新药清斑块,首年自费二十多万,还要担着脑水肿风险,也只能让病情恶化慢四分之一。 一边是二十多万的天价药,一边是二十块钱的理疗机,换谁都想立刻让家里患者去试试。 但先别急,之前被寄予厚望的声光刺激也在老鼠身上大获全胜,真到了人体实验里,斑块却一点没少。 这台治肩周炎的机器目前只在单性别的小鼠身上跑通,它到底能不能在人类身上起效,还需要进一步的研究证明。
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Craig Mello kicking off the nephrology meeting ! @ASNKidney RNA medicines and oligo therapies will be the next generation cures for the kidney patients
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Hua Bai retweeted
未来AI超级组织会成为最新的形态 #商业思维 #ai #认知 #许茹冰
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掼蛋怎么玩♠️,#掼蛋
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Excited to share our newest study on COX2-PGE2 and antiviral innate immunity. Huge shoutout to all of the authors for their important contributions!
The COX2-PGE2-PKA axis suppresses antiviral immunity by inhibiting mtDNA-dependent STING activation dlvr.​it/TVzXlj
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Hua Bai retweeted
料酒去腥是騙局🤔 五種肉類 各有專屬去腥香料 牛肉胡椒 燉用白胡椒 猪肉用八角 冷水鍋 草果用羊肉 用之前拍裂 雞肉用花椒 最後20分鐘再放 魚是三甲安 白脂 燉前前10分鐘
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这段演讲,应该在拿结婚证的地方,看到能全文背诵后,拿证!
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Hua Bai retweeted
我以为我起码不会被ai音乐打动,但我错了。词曲演唱现场,都很丝滑。人类啊,颤抖吧!
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短短两天唱哭1400万人, 人生不是每句都是punchline。 那些平淡的、卡壳的、没押韵的句子,也是你的歌。 策划|词曲|AI制作:喆FILM
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这个福利 应该很多朋友都用的到 哈哈 (如何躺着玩手机 不伤身体)
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A team at the Wyss Institute and Harvard Medical School, led by George Church, with colleagues at CIC bioGUNE in Spain, screened for genes that make the activity patterns of human skin cells look younger. One of them, a splicing factor called SRSF1, reduced signs of aging in cultured cells without changing what kind of cells they were. In aged mice, switching it on slowed frailty and was associated with a 14% longer median lifespan. nature.com/articles/s43587-0…
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Five years ago, an important miscarriage of justice occurred. The story began in April 2018 when David Sabatini, an MIT, Howard Hughes Medical Institute (HHMI), and Whitehead Institute scientist and professor began a consensual intimate relationship with Dr. Kristin Knouse, a principal investigator with her own lab at the Whitehead. By January 2020, David sought to end the relationship, but Knouse apparently did not want it to end. When David thereafter started a new relationship and Knouse learned about it, she began a secretive campaign to destroy him by attempting to end his career as a scientist. She did so by damaging his name, reputation, and that of his family with false sexual harassment and other claims, thereby making him unemployable. Knouse conspired with Dr. Ruth Lehmann, the then- and still current Director (i.e., President) of the Whitehead Institute, in her efforts to destroy Sabatini. The record presented in court demonstrated that Dr. Lehmann committed to Knouse in October of 2020 that she would fire David. Dr. Lehmann made this commitment to Knouse before any investigation of the facts had taken place. Seven months after committing to fire him, in March of 2021, Dr. Lehmann, on behalf of the Whitehead, hired the law firm of Hinckley, Allen, Snyder (HAS) to undergo an investigation of David. By July 2021, HAS shared a draft of its conclusions with MIT, HHMI, and the Whitehead, but not with David or his lawyers. On the morning of August 19, 2021, David for the first time received the more than 200-page investigative report and a calendar invite for a meeting the following day with Dr. Lehmann, the president of HHMI, and the HR directors of both institutions. The report was riddled with errors and unsupported claims about David and his relationship with Knouse. When David's lawyer immediately thereafter reached out to Whitehead counsel to ask whether David was about to be fired, they confirmed that he would be terminated at the meeting. On the advice of his lawyer, David immediately resigned from HHMI and the Whitehead rather than attend the meeting. HHMI did not accept his resignation, choosing instead to fire him. MIT put David on leave and ultimately revoked his tenure. David thereafter resigned from MIT. On August 20, 2021, one day after sending David the HAS report and before David had the opportunity to dispute the facts and the conclusions of the investigation, Dr. Lehmann emailed all employees at the Whitehead informing them that David had violated a number of Whitehead policies "including policies concerning sexual harassment." The Lehmann public email, David's resignation and firing, and Dr. Lehmann's claims about David's sexual harassment exploded into a major global scandal covered in mainstream, social, and scientific media around the world as it had all of the requisite ingredients: An attractive target with David, one of the most important scientists of his generation in line for the Nobel Prize, a purported inappropriate sexual relationship with a younger female colleague, and a political and institutional environment where punishing a man for sexual harassment advanced the career and reputation of the person and/or institution that destroyed the career and reputation of the accused, regardless of the validity of the allegations. As a result of Knouse's claims, Lehmann's sham investigation, and the media onslaught that followed, David lost all sources of income and his reputation was destroyed. All prizes he had been previously been awarded were withdrawn. He was removed from all scientific advisory and other honorary roles other than as a member of our family foundation's (the Pershing Square Foundation's) scientific advisory board. When I initially learned of the news about David in the summer of 2021, I hired him as a consultant to the Pershing Square Foundation as I believed our small foundation team would benefit greatly by his insights (and he now had the time to help us), and he needed the money to support his family. At my request and under a confidentiality agreement, David provided us with many hundreds of pages of documents including texts and other communications with Knouse, the investigative report, and David's responses to the allegations so that we could do our own evaluation of Knouse's claims. I and a member of our family office's legal team carefully reviewed the documents. After a careful review of the empirical documents -- in particular the texts between Knouse and David -- it became abundantly clear that Knouse's actions were that of an angry and jilted lover, not those of a sexually harassed junior colleague. And the investigative report appeared designed to deliver a pre-ordained conclusion rather than a dispassionate fact-based analysis. The impact of the firings and the destruction of his career and reputation on David and his family was extraordinarily devastating, so much so that we became increasingly concerned that he might commit suicide. [In order to make sure that David's important scientific research would continue, in February 2023, in partnership with an anonymous donor, we funded $25 million to support David launching a new lab. As you might expect, I was reviled in the press, in scientific journals, and on social media for doing so and for supporting a so-called sex offender.] On October 20, 2021, David filed suit against Knouse alleging defamation and tortious interference in his career and his contractual arrangements. Thereafter, Knouse brought counterclaims against David. Today, nearly five years to the date of the filing of the suit, he has finally received justice. Today, a 13-person jury (seven men and six women) of David Sabatini's peers (12 jurors plus an alternate) unanimously determined that David proved that Kristin Knouse defamed him, tortiously interfered with his contractual relationships (his entire career as a scientist), and tortiously interfered with his prospective advantageous relationships (his future employment). The jury awarded him nearly $10 million in damages including interest. The jury rejected all of Knouse's claims including her claims that David engaged in quid pro quo sexual harassment and created a sexually hostile work environment. While five years is a very long time to live under a reputational cloud, justice was finally served today for David, but not completely in my view. To this day, Dr. Ruth Lehmann remains Director of the Whitehead Institute. Dr. Lehmann worked alongside Dr. Knouse to destroy David Sabatini, an acclaimed scientist and professor. She did not follow due process before she intentionally destroyed David's career and reputation. Dr. Lehmann nearly killed David with her actions, as had we not rescued David by finding him employment, supporting him publicly to buffer the reputational damage, and supporting his recovery, he could have ended his life and left his son without a father before the world understood what had transpired here. And the reputational damage was not just to David. David's brother, Bernardo Sabatini, is one of the most important neuroscientists in the world. To this day, he has had to deal with a large cloud over his family name and reputation. Recently, when the new CEO of our brain institute mentioned that Bernardo Sabatini was on our board, he was asked: "Wasn't he involved in some kind of sex scandal?" For obvious reasons, the character of the person who runs a scientific institute is of utmost importance. Among other failures here, Dr. Ruth Lehmann committed to Knouse that she would fire David many months before an investigation was even launched and without consideration of the empirical facts. How can one trust research produced by a scientific institute if its leader is not committed to observing the empirical facts before reaching conclusions that have life-threatening import? We have unfortunately seen massive amounts of scientific fraud which has harmed innumerable human lives and wasted billions of dollars of research funding and time. For her ethical breaches here, Dr. Lehmann should be fired from the Whitehead. Based on her actions in this case, she is in no position to serve as the leader of an important scientific institute. I speak with some perspective on how scientific and other institutions should be led. Including the recent launch of the Ackman Oxman Institute, we have funded approximately $1 billion of scientific research and institutions over the last decade or so, and this experience has given us the opportunity to meet the leadership of many of the most important scientific institutions in the world. To put it plainly, we would not give a dollar to a scientific institute whose leader compromised basic moral principles as has happened here. At an absolute minimum, the board of the Whitehead should immediately launch a detailed and independent investigation of Dr. Lehmann's actions in the Sabatini case. I would encourage the investigation, among other considerations, to carefully exam all of the correspondence between Lehmann and Knouse, as well their correspondence with the HAS law firm on among other areas, the various drafts of the Sabatini investigative report. Alternatively, Dr. Lehmann could resign, minimize further distraction for the Whitehead, and save institutional time and resources that would be better spent on research that benefits humanity.
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认清人性的底色,人性宝典 v.v8l.cn/s/EHg99bR pan.baidu.com/s/1AGi3oSu3xxS…
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认知决定命运的三个最好的例子
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A lovely commemorative collection @AgingJrnl in memory of Misha Blagosklonny. Misha was an original thinker who challenged conventional views of ageing. His hyperfunction theory, viewing ageing as a quasi-program rather than simply damage, is similar to my programmatic views.
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