A terrific body of work by postdoc Munisha Mumingjiang and grad student Rui Huang on the impact of genomic instability on trophoblast stem cells and placenta development. Years in the making. biorxiv.org/content/10.1101/…

A few decades ago, I remember writing in a % of admin salaries (say, a Departmental staffer) on my grants (part of DC). I guess rule changes since then pushed those all into IDC.

A high throughput CRISPR perturbation screen identifies epigenetic regulators impacting primordial germ cell development biorxiv.org/content/10.1101/… We found that a histone deacetylase KD, and HDAC inhibitors (inc. a dietary supplement), impede PGCLC formation> somatic genes stay on

Scalable and Efficient Generation of Mouse Primordial Germ Cell-like Cells biorxiv.org/content/10.1101/… If you need a ton of PGCLCs and don't want to use expensive cytokines in the process, you may find this method useful.

Thanks Cito for you great content! Been following you for a couple of years on YouTube, and as a result I too have focussed most of my Crupto interest on the Cosmos.

1 y.o. grand-daughter figures out how to make every putt!

Our studies of why genetic variant pathogenicity prediction algorithms leave much to be desired: pnas.org/doi/10.1073/pnas.22…