@TambarLab

Organic chemistry lab interested in reaction development, total synthesis, chemical biology, and drug discovery

 UT Southwestern Medical Center
utsouthwestern.edu/labs/tambar/
Joined April 2016
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  • Following610
  • Followers4.2K
251Media
Our lab discussed the career of Vladimir Gevorgyan. What’s your favorite paper from the @GevorgyanLab? Here are some papers selected by our lab: doi.org/10.1021/jacs.7b08459 doi.org/10.1021/jacs.9b04189 science.org/doi/10.1126/scie…
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UTSW Organic Chemistry Graduate Program knows how to party! Students and faculty had a lot of fun at our annual Summer Party at Top Golf Dallas! @UTSWMedCenter @UTSWGradSchool @TopgolfDallas
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We’re proud to share our recent paper on Synthetic Studies toward the Anacolosin Family of Clerodane Diterpene Natural Products @JOC_OL pubs.acs.org/doi/10.1021/acs… Also check out our Cover Art @ACSPublications #MyACSCover pubs.acs.org/toc/joceah/91/2… @callmefortuNate @J_DiSapio
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Our lab discussed the career of Alison Narayan @AlisonNarayanUM. What’s your favorite paper from @NarayanLab? pubs.acs.org/doi/10.1021/jac… nature.com/articles/nchem.28… doi.org/10.1021/acs.analchem… dx.doi.org/10.1021/acs.accou… doi.org/10.1021/jacs.3c12393 doi.org/10.1021/acs.jpcb.5c0… doi.org/10.1039/c1ob06423a
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It was great hosting Dr. Stephen Starnes and the REU students from East Texas A&M University @etamuniversity! We had a fun day talking about the Drug Discovery process with young scientists. Thank you Dr. Arnaldo Díaz @ADiaz_PhD for sponsoring the event. See you all next year!
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Check out this formal [3+3] annulation developed by Movassaghi to assemble the CDE-ring system of himandrine.
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Stoltz completed an elegant synthesis of ineleganolide (pun intented) with this cascade sequence to furnish the pentacyclic core. @thestoltzgroup
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Check out this elegant cascade sequence reported by Ang Li for the asymmetric total synthesis of arcutinidine, arcutinine, and arcutine.
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Check out this elegant tandem cascade en route to the total synthesis of (+)-Lycoflexine, which was reported by Jürgen Ramharter and co-workers.
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Check out this elegant benzyne-mediated tandem reaction for the rapid assembly of nitrogen heterocycles, which was reported by Richard Hsung. Do you know the mechanism?
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Our lab recently discussed the research career of Andrew Myers. What’s your favorite paper from the Myers Lab? Here are some papers selected by us: pubs.acs.org/doi/10.1021/ja9… science.org/doi/10.1126/scie… pubs.acs.org/doi/10.1021/acs… nature.com/articles/nchem.79… pubs.acs.org/doi/10.1021/acs…
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Our lab recently discussed the career of our Eric Jacobsen @JacobsenLab. What’s your favorite paper from Jacobsen? Here are some papers selected by us: nature.com/articles/s41586-0… pubs.acs.org/doi/10.1021/ja0… pubs.acs.org/doi/10.1021/ja0… pubs.acs.org/doi/10.1021/acs… pubs.acs.org/doi/10.1021/jac…
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Our lab recently discussed the career of our good friend Mingji Dai @MingjiDai. What’s your favorite paper from the Dai Lab? Here are some papers selected by us: pubs.acs.org/doi/10.1021/jac… onlinelibrary.wiley.com/doi/… pubs.acs.org/doi/10.1021/jac… pubs.acs.org/doi/10.1021/jac…
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Our lab recently discussed the career of our good friend David Nagib @nagiblab. What’s your favorite paper from Nagib? Here are some papers selected by us: pubs.acs.org/doi/10.1021/jac… nature.com/articles/nature10… pubs.acs.org/doi/10.1021/ja9… pubs.rsc.org/en/content/arti…
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Our lab recently discussed the research career of Veronique Gouverneur. What’s your favorite paper from the Gouverneur Lab? Here are some papers selected by us: doi.org/10.1021/jacs.3c01303 science.org/doi/10.1126/scie… pubs.rsc.org/en/content/arti… science.org/doi/10.1126/scie…
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We’re hiring a biology postdoc in the Tambar Lab at UT Southwestern! Interested in chemical biology, protein-small molecule interactions, target engagement, and targeted protein degradation? We’d love to hear from you. PhD required. @utswpda Apply here: apply.interfolio.com/187301
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TambarLab retweeted
Pradip Maity@pmaity2May 28
Our work on direct and redox-neutral C–H functionalization of pyridines with nucleophiles @J_A_C_S @ACSPublications Congratulations @BARALNILOFAR #NPDF @Pinku_Saikia25 @Devendr57748399 and Sabir pubs.acs.org/doi/10.1021/jac…

A Mild and Site-Selective Nucleophilic C–H Functionalization of Pyridines via Its Stable N‑Alkyla...

Abstract. Direct, site-selective C–H functionalization of pyridines offers an efficient approach to both streamlined synthesis and late-stage modification

pubs.acs.org
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Our lab recently discussed the research career of our good friend Neil Garg @GargLab @uclachem @UCLA. What’s your favorite paper from the Garg Lab? Here are some papers selected by us: pubs.acs.org/doi/10.1021/ja0… pubs.acs.org/doi/full/10.102… nature.com/articles/nchem.23…
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Check out this cool cascade oxidative trifluorination and halogenative cyclization of tryptamine-derived isocyanides, which was recently reported by Honggen Wang and Qingjiang Li. Do you know the mechanism?
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Check out our review in @JournalCancer on recent advances in targeting HIF‐2 in renal cell carcinoma, with a focus on belzutifan. Academic labs can have a tangible impact on the treatment of cancer patients. @AmericanCancer @utswcancer @UTSWMedCenter acsjournals.onlinelibrary.wi…

Targeting HIF‐2α in renal cell carcinoma: Expanding upon belzutifan

This review highlights the evolution of therapeutic strategies targeting hypoxia-inducible factor-2α (HIF-2α) in clear cell renal cell carcinoma, from the discovery of belzutifan to the development...

acsjournals.onlinelibrary.wiley.com
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