@TMEM_Samuel

Cancer Researcher; researching Tumor-Microenvironment interactions @CCB_Research. https://xitter.cf/t.co/E52xXzSLNR…

 Adelaide, Australia
centreforcancerbiology.org.au/research/tumour-microenvironment-laboratory/
Joined January 2009
  • Tweets1.6K
  • Following1.4K
  • Followers851
67Media
Michael Samuel retweeted
Sharad Kumar@molregulationMar 20
Great to see this work led by Bekky Feltham @WEHI_research and the global ubiquitin community now published. Happy to have contributed to the curation of HECT E3s.@CCB_Research The E3-ome gene-centric compendium reveals the human E3 ligase landsca... sciencedirect.com/science/ar…
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I am delighted to be able to share that our latest paper arising from a project co-led by @DrSarahBoyle and me is now out in the world, published in AAAS Science Advances: science.org/doi/10.1126/scia….

Compressive stress–driven Piezo1 activation and Rho-ROCK mechanotransduction promote tumor progre...

Compressive force drives PIEZO1-RHO-ROCK mechanotransduction and establishes an epigenetic memory that promotes tumor progression.

science.org
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Sarah has a more detailed narrative of our findings here: xitter.cf/DrSarahBoyle/status/20…
Sarah Boyle 👩🏻‍🔬🎀@DrSarahBoyleMar 9
We are very excited to share our newest results, published in Science Advances: “Compressive stress-driven Piezo1 activation and Rho-ROCK mechanotransduction promote tumor progression via epigenetic mechanical memory”. doi.org/10.1126/sciadv.aeb12…

Compressive stress–driven Piezo1 activation and Rho-ROCK mechanotransduction promote tumor progre...

Compressive force drives PIEZO1-RHO-ROCK mechanotransduction and establishes an epigenetic memory that promotes tumor progression.

science.org
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Thank you to all our lab members and colleagues who contributed to this research, and the funding bodies who supported our work: @hosp_research, @nhmrc @arc_gov_au , @WorldwideCancer
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dx.doi.org/10.1126/sciadv.ae…

Compressive stress–driven Piezo1 activation and Rho-ROCK mechanotransduction promote tumor progre...

Compressive force drives PIEZO1-RHO-ROCK mechanotransduction and establishes an epigenetic memory that promotes tumor progression.

science.org
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Why ‘being squeezed’ helps breast cancer cells to thrive “intense physical pressure at early stages of the disease… leaves a lasting ‘mechanical memory’ in breast cancer cells, promoting aggressive behaviour after the pressure itself has been relieved.” eurekalert.org/news-releases…

Why ‘being squeezed’ helps breast cancer cells to thrive

A new study led by researchers at Adelaide University and published in Science Advances has revealed why some cancers can grow and survive in the body, while others cannot.

eurekalert.org
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We are very excited to share our newest results, published in Science Advances: “Compressive stress-driven Piezo1 activation and Rho-ROCK mechanotransduction promote tumor progression via epigenetic mechanical memory”. doi.org/10.1126/sciadv.aeb12…

Compressive stress–driven Piezo1 activation and Rho-ROCK mechanotransduction promote tumor progre...

Compressive force drives PIEZO1-RHO-ROCK mechanotransduction and establishes an epigenetic memory that promotes tumor progression.

science.org
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In a study co-led by myself and Prof @TMEM_Samuel at @CCB_Research, Adelaide University, we found breast cancer cells subjected to compression, such as experienced during tumour growth in the restricted mammary duct, are changed in ways that worsen the resulting tumours.
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More on compression! @TMEM_Samuel @CCB_Research detailed how compressive stress from rapid mammary tumour growth triggers a Piezo1-dependent pathway that activates Rho-ROCK-mediated mechanosignaling contributing to a mechanical memory that drives cancer progression. #MBIMPG2025
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Our lab is seeking a postdoctoral scientist to work with us on an exciting new project modelling cancer extracellular matrix structures using nanofabrication approaches. Full details are at shorturl.at/fF4OC.
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brnw.ch/21wPsyJ Five UniSA projects awarded $5mill in @NHMRC grants announced today are set to improve cancer treatment, & help people prioritise their time building health
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Summer is coming and so are the @CCB_Research @UniversitySA 2024/25 Vacation Scholarships for a 4-8 week research intensive in cancer biology!! There are also $100/week top ups kindly donated by the Fuss Family and @lashesofchange closes: 22 Sept 👇👇👇 unisa.edu.au/research/degree…
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Our colleague @s_pitson at @CCB_Research @UniversitySA will be trekking the Kakoda Trail in October raising funds for @NeuroSurgRF, particularly for an important research project led by A/Prof. Quenten Schwarz to find better treatments for children with brain cancers.
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Michael Samuel retweeted
ANZSCDB@ANZSCDB7 Aug 2024
We are excited to announce the 12th ANZSCDB South Australia meeting taking place on October 16, 2024! Join us for insightful talks from @McGlinnLab, @CedricBardyLab, and @Lisa_M_Nic at @unisa. Don't miss this packed event! #devbio #science #cellbiology
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Another exciting #openaccess paper in #cytoskeleton @CytoskelJournal Enhanced RHO-ROCK signaling is associated with CRELD2 production and fibroblast recruitment in cutaneous squamous cell #carcinoma onlinelibrary.wiley.com/doi/… @TMEM_Samuel #cancer #science #cell #cellbiology
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Michael Samuel retweeted
Small GTPases@SmallGTPases11 Jul 2024
Enhanced RHO‐ROCK signaling is associated with CRELD2 production and fibroblast recruitment in cutaneous squamous cell carcinoma - Pittar - Cytoskeleton - Wiley Online Library onlinelibrary.wiley.com/doi/…

Enhanced RHO‐ROCK signaling is associated with CRELD2 production and fibroblast recruitment in...

A key characteristic of cancer cells is their ability to induce changes in their microenvironment that render it permissive to tumor growth, invasion and metastasis. Indeed, these changes are...

onlinelibrary.wiley.com
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Enhanced RHO‐ROCK signaling is associated with CRELD2 production and fibroblast recruitment in cutaneous squamous cell carcinoma dlvr.it/T9PLcW

Enhanced RHO‐ROCK signaling is associated with CRELD2 production and fibroblast recruitment in...

A key characteristic of cancer cells is their ability to induce changes in their microenvironment that render it permissive to tumor growth, invasion and metastasis. Indeed, these changes are...

onlinelibrary.wiley.com
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