MD, PhD candidate HPB Surgery Amsterdam UMC 🇳🇱| Former Research Fellow Karolinska University Hospital 🇸🇪 & University of Colorado 🇺🇸
Amsterdam, Nederland
Joined June 2022
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Published in @TheLancet, our review on #PancreaticCancer
📎Epidemiology🌎
📎Pathogenesis🔬
📎Risk factors & surveillance🕵️
📎Diagnostics🩺
📎Treatment💊
📎Future directions🔍
… by @ammar_asrar, @ObaAtsushi, T. Seufferlein, JW Wilmink, @BasGrootKoerkam & @MarcBesselink
Thomas Stoop retweeted
Surgical outcomes from nationwide implementation of the international best practice for locally advanced pancreatic cancer (PREOPANC-4) study
➡️ doi.org/10.1093/bjs/znag075
Nationwide implementation of the international best practice for LAPC was feasible with nearly three times more resections performed than expected, while morbidity and mortality remained well within predefined safety benchmarks
Work by Thomas F Stoop , Leonard W F Seelen , Freek R van ‘t Land , Jacobien C M Scheepens , Mahsoem Ali , Anna C van der Hout , B Marion van der Kolk , Bert A Bonsing , Daan J Lips , Eric R Manusama , François E J A Willemsen , Freek Daams , Geert Kazemier , Gijs A Patijn , Ignace H de Hingh , Jan H Wijsman , Jennifer Schreinemakers , Joris I Erdmann , J Sven D Mieog , Joost M Klaase , Judith A C Rietjens , Koop Bosscha , Lysanne P M Beuk , Maarten W Nijkamp , Marcel den Dulk , Marnix P M Kop , Mike S L Liem , Misha Luyer , Martijn W J Stommel , Olivier R Busch , Sebastiaan Festen , Stefan Bouwense , Tom M Karsten , Tom W van Ravens , Ulff P Neumann , Vincent E de Meijer , Vincent B Nieuwenhuijs , Werner A Draaisma , Wouter Derksen , Thomas L Bollen , Bas Groot Koerkamp , Casper H J van Eijck , I Quintus Molenaar , Christopher L Wolfgang , Marco Del Chiaro , Matthew H G Katz , Thilo Hackert , Johanna W Wilmink , Hjalmar C van Santvoort , Roeland F de Wilde , Marc G Besselink , the Dutch Pancreatic Cancer Group
#SoMe4Surgery #MedTwitter #SurgEd #Surgery @RCPSGTrainees @aecirujanos @SEIQuirurgica @iss_sic #MedicalTechniques @BJSAcademy @young_bjs @BJSOpen @evanscolorectal @robhinchliffe1 @bplwijn @MalinASund @nfmkok @TejedorPat @paulo_sutt @PVaughanShaw @JJEarnshaw @juliomayol @ksoreide #some4hpb #some4tpl @DPCG_official @pancreatitis_nl @PancreasClub #PancreasClub2023 #PancreaticCancer #Pancreatitis #HCC @PanCAN #PanCANawareness @EurPancClub @P_C_E_ @dice_europe #PancreaticCancer #cholangiocarcinoma #HPBSurgery #GallbladderCancer #Oncology #LiverSurgery
In @BJSurgery, #LAPC surgical outcome #PREOPANC4 implementation of best-practice LAPC care in #DPCG 🇳🇱 with help of 🇩🇪🇺🇸 experts.
📎 154 LAPC resections 🇳🇱
📎~3x ⬆️ resections than expected
🕵️ in-hosp/30d benchmarks✅:
📍44% major morbidity (<50%)
📍0.6% mortality (<=5%)
👇
Open access 🗞️: academic.oup.com/bjs/advance…
Thomas Stoop retweeted
Neurogenic diarrhoea after superior mesenteric artery divestment or resection for pancreatic adenocarcinoma following preoperative chemotherapy: international multicentre retrospective study
➡️doi.org/10.1093/bjsopen/zrag…
In this international multicentre study including 291 patients with superior mesenteric artery (SMA) divestment/resection during surgery for pancreatic adenocarcinoma after preoperative chemotherapy, postoperative neurogenic diarrhoea occurred in 66% of patients, particularly after > 180° SMA divestment or resection. Although challenging to manage, neurogenic diarrhoea was not associated with impaired survival.
👏👏👏@TFStoop , Chiara Croce , Hiroyuki Ishida , Mahsoem Ali , Ammar A Javed , Asif Halimi , Atsushi Oba , Bas Groot Koerkamp , Carl-Stephan Leonhardt , Cornelius A Thiels , Elena Rangelova , Ernesto Sparrelid , Ira Sotirova , Jennifer L Leiting , Jun Tauchi , Kosuke Kobayashi , Marit Klos , Lysanne P M Beuk , Luana Genova , Manuela Mastronardi , Michael L Kendrick , Nabiha A Mughal , Olivier R Busch , Oskar Franklin , Patrik Larsson , Ulla Klaiber , Richard D Schulick , Rutger T Theijse , Oliver Strobel , Poya Ghorbani , Roeland F de Wilde , Salvador Rodriguez Franco , Toshitaka Sugawara , Johanna W Wilmink , Wells Messersmith , @MarcBesselink , Christopher Wolfgang , Yosuke Inoue , Mark J Truty , @chiaro_del on behalf of the , International Collaboration on Advanced Pancreatic Cancer
#SoMe4Surgery #MedTwitter #SurgEd #Surgery @BJSAcademy @BJSurgery #some4hpb #some4tpl @hpb_so #PancreaticCancer #PancreaticSurgery @YouppiePancreas @German_PancClub @surgery_hps #PancreasClub2023 @PancreasClub @DPCG_official @pancreatitis_nl @PanCAN #PanCANawareness @EurPancClub @P_C_E_ @dice_europe
In @BjsOpen, study 🇳🇱🇩🇪🇸🇪🇺🇸🇮🇹 on surgery risks in #pancreascancer #LAPC after preop RTx ☢️:
⬆️ major morb after RT (38% vs 24%)
📎especially if arterial resection
📎especially if EBRT
🖇️no significant association of RT with PPH 🩸 (11% vs. 5%)
🚨selection & counselling
Full text 🗞️: academic.oup.com/bjsopen/art…
In @BjsOpen, study 🇳🇱🇦🇹🇺🇸🇯🇵🇸🇪 on #neurogenic #diarrhea after #pancreaticcancer surgery with SMA divestment/resection:
📎66% rate, mostly if >180° SMA divestment/resection
🚨large treatment heterogeneity ➡️ 51% normalized
👍 no ⬇️ OS
🔎definition & evidence-based strategies⚠️
Full text 🗞️: academic.oup.com/bjsopen/art…
Thomas Stoop retweeted
Original Article: Daraxonrasib or Chemotherapy in Previously Treated Metastatic Pancreatic Cancer (phase 3 RASolute 302 trial) nej.md/4nWaxvM
#ASCO26 | @ASCO
ALT A two-panel line graph shows overall survival in two populations, comparing darovasertib (blue line) and chemotherapy (gray line) treatments. Panel A depicts the RAS G12 population, while Panel B shows the overall population. Hazard ratios and confidence intervals are detailed in each panel.
ALT This image shows two line graphs titled "Progression-free Survival in the RAS G12 Population" and "Progression-free Survival in the Overall Population." Both graphs compare survival rates over 13 months between two groups: one receiving darovasertib and the other receiving chemotherapy. Accompanying the graphs are tables detailing the number of events and patients at risk for each treatment group.
Thomas Stoop retweeted
#HoraEst 🎓 @IngmarFRompen today @UvA_Amsterdam “Extended indications for #pancreatic #surgery (#promotie). Well done Ingmar!!
➡️ dare.uva.nl/id/9c78faf9-53e8…
🎯Amazing thesis including 14 chapters, all published, including 9x(!!) @AnnalsofSurgery. Thanks to all 99 co-authors from 🇩🇪🇺🇸🇳🇱 🇮🇹🇳🇴🇸🇪🇫🇮🇩🇰🇬🇧🇯🇵
✅ Wonderful collaborative PhD team @MarcBesselink @cw_michalski 🇩🇪 @cwolfga2 🇺🇸 @ammar_asrar 🇺🇸 @DPCG_official
Thanks to the excellent committee including @Gio_Marchegiani @TFStoop @i_verpalen @HenrikNien
Thomas Stoop retweeted
#PELICAN randomized trial @DPCG_official 🇳🇱 published @JAMANetworkOpen:
❓Can #RFA following induction chemoth improve survival vs chemoth only in 188 pts with nonprogressive but nonoperable locally advanced #pancreaticcancer (#LAPC)?
🔑 No. Moreover QoL ⤵️ 👀
#PREOPANC4 coming up.
▶️ jamanetwork.com/journals/jam…
Thomas Stoop retweeted
#Horaest 🎓 @TFStoop #CumLaude PhD ceremony today 🙌 (best 3% thesis)
“A #paradigm #shift in localized #PancreaticCancer” @DPCG_official, @UvA_Amsterdam
⏩️ dare.uva.nl/search?identifie…
✅#PREOPANC4 nationwide 🇳🇱 implementation LAPC surgery
✅International, national studies on #neoadjuvant #adjuvant treatment #quality of life and #surgery in #PancreaticCancer
✅543 pages, 19 chapters (incl @TheLancet), 150 co-authors, 20 countries, 286 impact factor points; median 10+.
Thank you @sparrelid🇸🇪 for the excellent discussion!
Thomas Stoop retweeted
Proud to have Dr.Oba in our Division! Dive into the story below.
Read all about it! Japanese Surgeon Atsushi Oba, MD, PhD, Joins Pancreatic Program At CU Anschutz Department of Surgery. @ObaAtsushi @CUpancreas @CUDeptSurg #ImproveEveryLife
news.cuanschutz.edu/departme…
Thomas Stoop retweeted
Bihormonal Artificial Pancreas after #Total #Pancreatectomy?
✅Protocol #PANORAMA trial published @BjsOpen @DPCG_official 🇳🇱 >> results coming up….
⏩️ academic.oup.com/bjsopen/art…
Thomas Stoop retweeted
We extend our sincerest gratitude to Dr. Schulick for his exceptional service as Chair of the @CUDeptSurg, during which he guided significant growth and innovation. His vision and dedication leave an extraordinary impact. #ImproveEveryLife @RichSchulickMD @chiaro_del
Thomas Stoop retweeted
#HoraEst today for @annegehrels om #PancreaticCancer with
@DPCG_official 🇳🇱 @UvA_Amsterdam
⏩️ hdl.handle.net/11245.1/0af5e…
✅#NAPAN trial: Second-line liposomal irinotecan plus S-1 vs. liposomal irinotecan plus 5-fluorouracil in metastatic pancreatic cancer: the phase I/II randomized trial
✅#PREOPANC5 trial protocol: Neoadjuvant mFOLFIRINOX, pembro, and SBRT for borderl resect pancreatic cancer: multicenter phase 1/2 single-arm trial
Excellent multidisciplinary collaboration Hanneke Wilmink, Hanneke van Laarhoven an in the committe Davide Melisi 🇮🇹
Thomas Stoop retweeted
#HoraEst today for @MichielFrancken @amsterdamumc @UvA_Amsterdam
“Interventions for pancreatic diseases”
✅ #POINTER trial costs
✅#PICUS2 cholecystectomy for idiopathic pancreatitis, trial design
✅#PANACOTTA (obot vs open PJ chronic pancreatitis, trial design
Incl committee @DeMadaria 🇪🇸 gracias Enrique🙌
dare.uva.nl/search?field1=ke…
Thomas Stoop retweeted
The evidence would support performing diag
laparoscopy prior to #NAT💊 and surgery✂️
22% detection rate of occult metastases on🥢
in upfront resection pts in modern series with
high quality imaging 🖥️ at experienced center
@PanCAN @SocSurgOnc @IHPBA
pmc.ncbi.nlm.nih.gov/article…
Staging laparoscopy 🙈 waste of time or added value!?
🗣️ 617 Surgeons / 76 countries
⏱️ Mostly performed same session laparotomy
🧐 Useful in suspicious radiology / ⬆️ CA 19.9
👉 Does not hurt + increase staging accuracy
hpbonline.org/article/S1365-…
Thomas Stoop retweeted
Staging laparoscopy to detect occult metastases in localized pancreatic cancer: global survey among nine international societies hpbonline.org/article/S1365-…
Thomas Stoop retweeted
The Division of Surgical Oncology is thrilled to welcome Atsushi Oba, MD, PhD as Associate Professor of Surgery at the University of Colorado Anschutz Medical Campus! @CUpancreas @CUDeptSurg @ObaAtsushi #ImproveEveryLife
