A SAGE Open Access journal | Publishing high-quality articles in infectious disease | Editor-in-Chief @andhen25 | IF 3.8
SAGE Publishing, London
Joined February 2020
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🦠 When standard antifungals fail, what are the options?
A challenging case of multidrug-resistant Candida auris osteomyelitis highlights the potential role of fosmanogepix alongside aggressive surgical source control.
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🦠 Explore the latest research on Group B Streptococcus (GBS), spanning colonization trends, transmission, antimicrobial resistance, neonatal disease, and prevention strategies.
📚 Discover all the abstracts here: journals.sagepub.com/doi/ful…
🦠 Pseudomonas aeruginosa UTIs in Palestine: In a 190-patient cohort, mortality was 11.6%. Immunocompromised status & meropenem resistance were independent predictors of mortality, highlighting early risk recognition and appropriate antimicrobial therapy.
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Often mistaken for TB, Histoplasma can affect immunocompetent and immunocompromised patients. This review highlights critical diagnostic gaps, and proposes a pragmatic testing pathway while outlining priorities for future research.
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Candida tropicalis spondylodiscitis: a rare, indolent infection that can be easily missed.
Persistent fever and elevated β-D-glucan should prompt consideration of an occult fungal focus.
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In hospitalized children with LRTIs, multiplex RT-qPCR detected ≥1 pathogen in 78.5%. Viral-only detection was most common (40.9%), while viral–bacterial co-detection occurred in 26%.
Importantly, detection ≠ causation,
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TB stigma remains a major barrier to TB control. In this study of 385 patients in Napak district, Uganda, 43.1% reported high perceived stigma. Poor TB knowledge, inadequate social support, and secondary education were associated with higher stigma
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Mining may be an important occupational risk factor for TB.
In a case-control study from Ethiopia (n=735), miners had >3× higher odds of active pulmonary TB (AOR 3.51, 95% CI 1.89–6.50).
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New modeling data on RSV prevention in infants: seasonal clesrovimab, particularly with catch-up, was projected to reduce RSV-LRTIs and healthcare costs compared with palivizumab, nirsevimab, and maternal vaccination.
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AMR strategies in LMICs focus on access, stewardship, and surveillance, but overlook whether antibiotic exposure is adequate. Subtherapeutic concentrations can contribute to Rx failure&resistance. TDM-guided dosing may optimize exposure, improve outcomes.
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Antibiotic resistance is a major challenge in diabetic foot ulcers, particularly in LMICs.
This systematic review found high rates of resistance, including MRSA (38.7%), ESBL-producing E. coli (50.7%), and ESBL-producing K. pneumoniae (41.5%).
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Drug–drug interactions can shape COVID-19 antiviral prescribing. In this Thai outpatient cohort, statin use was the only independent predictor of choosing molnupiravir over nirmatrelvir/ritonavir (aOR 0.46, 95% CI 0.27–0.79)
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ALT flares in chronic hep B may signal both immune control and harm. In untreated patients, flares were linked to decompensation, hospitalization, and death; after treatment initiation, they were linked to HBsAg/HBeAg loss without adverse outcomes.
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New research from Panama explores ART adherence and retention in HIV care. Interviews with PLHIV highlight how daily routines, supportive care, stigma, food insecurity, transportation, side effects, and ART access all shape engagement in care
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🚨 This systematic review & meta-analysis (7 RCTs, N=3,589) finds that the 2-drug regimen Doravirine/Islatravir (100 mg/0.25 mg) achieves non-inferior viral suppression at 48 weeks
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TB + acute intermittent porphyria: a therapeutic tightrope.
This case of peritoneal TB highlights severe porphyric crises after HRZE, the challenges of building a safer TB regimen, and the need for individualized, shared decision-making
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Toxocariasis and the lung: A systematic review of 65 studies (989 patients) found respiratory manifestations spanning nodules, infiltrates and GGO, with eosinophilia in 89%
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High-risk HPV was detected in 65% of MSM with HIV tested in Bamako, Mali—and HPV16 in 12%. Self-collected anal swabs could make HPV screening more accessible in resource-limited settings.
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In this XDR typhoid study contaminated water, poor sanitation, street-food consumption, season were associated with severe disease. Meropenem and azithromycin showed the highest susceptibility, highlighting the narrow therapeutic options in XDR typhoid. journals.sagepub.com/doi/ful…
🫁 Why does diabetes increase the risk of severe influenza and ARDS? This review delves into the pathogenesis and offers a framework into a bedside approach to immunomodulatory therapy. journals.sagepub.com/doi/ful…