@Synth_Immune

Ragon Early Independence Fellow @ragoninstitute. PhD in Immunology from @harvardmed. @jkagan1 lab alum. Cell biologist. Immunologist. Canoer. Hiker.

 Boston, MA
ragoninstitute.org/evavold/
Joined August 2019
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  • Following458
  • Followers1.1K
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Charlie Evavold, find me @synth-immune.bsky.social retweeted
Ragon Institute@ragoninstituteSep 18
Immunologists, engineers, clinicians, and computational biologists work side by side at the Ragon Institute of Mass General Brigham, MIT, and Harvard in Kendall Square. Learn more: ragoninstitute.org #Immunology #InfectiousDisease #Cambridge #ScienceCareers #Biotech
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Charlie Evavold, find me @synth-immune.bsky.social retweeted
Tianli Xiao@tianli_xiaoSep 17
really excited to share my postdoc work, where we used humanized mice to discover the mechanisms of pancytopenia in patients with DPP9 deficiency, which wasn't recapitulated in conventional mouse models. We reveal a DPP9-CARD8 pyroptosis axis governing survival of human HSPCs.
Journal of Clinical Investigation
@jclinicalinvestSep 16
Nominating CARD8 and Caspase-1 as therapeutic targets for patients with Hatipoglu syndrome: doi.org/10.1172/JCI207530 Human DPP9 deficiency causes severe pancytopenia that is not recapitulated by conventional Dpp9-/- mice. Here, Tianli Xiao @tianli_xiao et al. @YaleMed have develop a new way to model this human genetic disease using CRISPR editing of human HPSCs in mice. The new humanized mouse model recapitulates cytopenia in DPP9 deficiency and reveals why patients with DPP9 deficiency have loss of blood cells. #GeneticDisease #RareDisease
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Charlie Evavold, find me @synth-immune.bsky.social retweeted
Dr. Anthony Letai@NCIDirectorSep 3
One of my top priorities is advancing cancer therapeutic vaccines. New Phase 3 mRNA vaccine results suggest we can train our immune systems to prevent recurrence—a key priority in @theNCI's new FY28 Annual Plan. Read about this research: go.nih.gov/GmRqPjS

Moderna cancer vaccine stops melanoma returning: what’s next for personalized treatments?

Nature - Promising trial results suggest cancer vaccines work and could be used to target other tumours.

nature.com
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Charlie Evavold, find me @synth-immune.bsky.social retweeted
NIH
@NIHAug 26
🔬The NIH Stadtman Investigator Program is accepting applications for tenure-track positions in the NIH Intramural Research Program. As a faculty member in the IRP, you’ll join a dynamic research community offering stable funding, intellectual freedom, shared resources, and access to a wide range of scientific expertise. 📅 Apply by Sept. 30, 2026 🔗 Apply: irp.nih.gov/stadtman 📧 Questions? [email protected]
The image shows a large brick building with white columns, identified as part of an NIH Stadtman Investigator Program advertisement. The text reads, "NIH Stadtman Investigator Program: Tenure-Track Positions. Applications Due: September 30, 2026." Two NIH logos are visible at the bottom. The foreground features trees and bushes.

ALT The image shows a large brick building with white columns, identified as part of an NIH Stadtman Investigator Program advertisement. The text reads, "NIH Stadtman Investigator Program: Tenure-Track Positions. Applications Due: September 30, 2026." Two NIH logos are visible at the bottom. The foreground features trees and bushes.

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Charlie Evavold, find me @synth-immune.bsky.social retweeted
Dan Michele@MicheleLabUMAug 27
Our department @UMPhysiology at @umichmedicine is hiring a tenure-track assistant professor open to all areas of biomedical research. Come join a supportive department focused on ground-breaking research and training the next generation of scientists! apply.interfolio.com/192361
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Charlie Evavold, find me @synth-immune.bsky.social retweeted
Eileen P. White, PhD@EileenWhitePhDAug 27
The Biological Sciences Division at the University of Chicago is conducting a division-wide, open-rank faculty search in Cancer Biology and Immunology: apply.interfolio.com/190755
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Charlie Evavold, find me @synth-immune.bsky.social retweeted
Dr. Anthony Letai@NCIDirectorAug 26
Pancreatic cancer is notoriously hard to treat, but we are making progress. Recent @theNCI -funded work that sheds light on mechanisms behind #daraxonrasib resistance and could help clinicians choose treatment combos that outsmart pancreatic tumors. go.nih.gov/AcvCu95

Acquired resistance to the RAS(ON) multi-selective inhibitor daraxonrasib guides rational combina...

Nature Medicine - Circulating tumor DNA analyses in 44 patients with pancreatic cancer receiving the RAS(ON) multi-selective inhibitor daraxonrasib as part of a phase 1/2 trial, and preclinical...

nature.com
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So much hope.
Revolution Medicines@RevMedicinesAug 26
The U.S. FDA approved the first multi‑selective oral RAS inhibitor in metastatic pancreatic cancer. More: revmed.com/media/news/13366/…
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Charlie Evavold, find me @synth-immune.bsky.social retweeted
Lydia Lynch@lynchielydiaAug 27
Princeton University seeks applications for an assistant, associate or full professor for the initiative at the interface between cancer, immunity, and metabolism at the Ludwig Princeton Branch. Application for Assistant, Associate, or Full Professor, Ludwig Princeton Branch 🐅🥼
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Charlie Evavold, find me @synth-immune.bsky.social retweeted
Sophie Janssens Lab@JanssensLabJul 28
Looking forward to joining the dendritic cell meeting in San Diego and meeting colleagues and friends. Will you join as well? Check out @www.dc2026sandiego.com
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Charlie Evavold, find me @synth-immune.bsky.social retweeted
Sophie Janssens Lab@JanssensLabJul 19
Almost 15 years after our initial observation that IRE1 is specifically active in cDC1s, we finally start understanding why… Check out the new study from @victor.bosteels, published in @natcomms.nature.com Paper in press @ rdcu.be/fur4Q
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Charlie Evavold, find me @synth-immune.bsky.social retweeted
Ragon Institute@ragoninstituteJul 14
Summer is here, and with it a new cohort of RISE interns getting hands-on experience in our labs. Meet Alden, Philip, Daëlie, and Bella in our first group! Learn More: ragoninstitute.org/rise-rago… #Interns #Immunology #Research #STEM #Researchers
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#Evavold lab staying cool with ice cream cake for my birthday. @ragoninstitute @harvardmed @MassGenBrigham
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Charlie Evavold, find me @synth-immune.bsky.social retweeted
Cell Biology J-Club@cell_clubJun 29
PIKfyve influences inter-organelle contacts with lysosomes to modulate the endoplasmic reticulum rupress.org/jcb/article-abst…

PIKfyve influences inter-organelle contacts with lysosomes to modulate the endoplasmic reticulum

Long associated with the regulation of the endolysosomal pathway, the authors show that the PIKfyve lipid kinase extends its sphere of influence to modulat

rupress.org
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Charlie Evavold, find me @synth-immune.bsky.social retweeted
Ragon Institute@ragoninstituteJun 23
Congratulations to Batista Lab research fellow Raphael Reyes, who has been awarded the 2026 Warren Alpert Distinguished Scholar Fellowship in Immunotherapy. The fellowship provides a stipend over two years to support his research. Learn more: ragoninstitute.org/2026/06/b…
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Charlie Evavold, find me @synth-immune.bsky.social retweeted
Ragon Institute@ragoninstituteJun 18
We are now accepting applications for this 2-year postdoctoral fellowship, which provides full salary and benefits to study under the guidance of a Ragon faculty member. Fellows pursue research in HIV, infectious disease, and more. Apply through Sep 30: ragoninstitute.org/ramon-are…
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Charlie Evavold, find me @synth-immune.bsky.social retweeted
Ragon Institute@ragoninstituteJun 16
Harikesh Wong has been named a 2026 Pew Scholar in the Biomedical Sciences, one of 21 chosen from 211 nominees this year. Read More: ragoninstitute.org/2026/06/w… #RagonInstitute #Immunology #MIT #EarlyCareerScientists #Biology
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Charlie Evavold, find me @synth-immune.bsky.social retweeted
Taekjip Ha@taekjipJun 12
We are thrilled to announce an opening for a tenure-track assistant professor in PCMM, Boston Children's Hospital and Harvard Immunology! Apply by August 2, 2026.
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Charlie Evavold, find me @synth-immune.bsky.social retweeted
Merav Cohen Lab
@MCohenLabJun 5
We are thrilled to share the newest publication from our lab! In this work, @RoiBalaban & @OriMoskowitz investigated the effect of #efferocytosis on #macrophage state and function in the #TME. science.org/doi/10.1126/scii…

Efferocytosis induces proangiogenic function and chromatin remodeling in tumor-associated macroph...

Effero-seq reveals efferocytosis induction of macrophage chromatin remodeling and proangiogenic function in the TME.

science.org
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Charlie Evavold, find me @synth-immune.bsky.social retweeted
Yale West Campus@YaleWestCampusJun 2
Congratulations to @Nelson_LaMarche, assistant professor @yalepathology @CancerYale, who has received a Breaking Barriers in Cancer Research award from the V Foundation bit.ly/4uRUpya @TheVFoundation

Yale Professor Awarded V Foundation Grant to Support Cancer Research

Nelson LaMarche, PhD, assistant professor of pathology, will receive the V Foundation for Cancer Research 2026 Breaking Barriers in Cancer Research (V Scholar)

medicine.yale.edu
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