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SynBio Journal MDPI@SynBio_MDPI26 Jan 2022

Hello, World! 🙋‍♀️Open Submissions for 🧪Original Articles, 📚 Reviews, 💬 Comments, 📨Communications, 🩺 Case Reports... on 🧬 #SyntheticBiology 🦠 #SynBio susy.mdpi.com/user/manuscrip…

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SynBio Journal MDPI@SynBio_MDPIOct 16

🧬📡 What if bacteria could communicate, coordinate, and make collective decisions like a programmable system? 📖Read more at: mdpi.com/2674-0583/4/4/20 #SyntheticBiology #QuorumSensing #MicrobialCommunication #GeneCircuits #BacterialEngineering #MicrobiomeEngineering

Communication Circuits in Bacteria

Quorum sensing (QS) has emerged as a central mechanism by which bacteria coordinate gene expression across populations. As synthetic biology has advanced, QS has been developed into a widely exploi...

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SynBio Journal MDPI@SynBio_MDPIOct 13

🧬🦠 Can computational design turn bacteriophage genes into a modular toolkit for synthetic biology? 📖Read more at: mdpi.com/2674-0583/4/4/19 #SyntheticBiology #BacteriophageEngineering #ComputationalBiology #ComparativeGenomics #CodonOptimization #GeneticEngineering

A Computational Framework for Synthetic Minimal Bacteriophage Gene Set Design: Application to...

Minimal gene set design, reducing a system to its smallest functional part set, is a core synthetic biology strategy. Bacteriophages are attractive but underused chassis, yet wild-type phages are...

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SynBio Journal MDPI@SynBio_MDPIOct 8

🧬🌱 Could Pseudomonas chlororaphis become a versatile new host for synthetic biology? 📖Read more at: mdpi.com/2674-0583/2/2/7 #SyntheticBiology #Pseudomonas #MetabolicEngineering #Biotechnology #Violacein #Bioproduction #MicrobialEngineering #Fermentation #QuorumSensing

Development of SynBio Tools for Pseudomonas chlororaphis: A Versatile Non-Pathogenic Bacterium Host

Pseudomonas chlororaphis ATCC 9446 is a non-pathogenic bacterium associated with the rhizosphere. It is commonly used as a biocontrol agent against agricultural pests. This organism can grow on a...

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SynBio Journal MDPI@SynBio_MDPIOct 8

🧬🧪 Could in vitro Type II polyketide synthase systems expand the toolbox for synthetic biology and biocatalysis? 📖Read more at: mdpi.com/2674-0583/2/1/6 #SyntheticBiology #PolyketideSynthase #TypeIIPKS #Biocatalysis #NaturalProducts #MetabolicEngineering #Antibiotics

Expanding the Biosynthetic Toolbox: The Potential and Challenges of In Vitro Type II Polyketide...

Type II polyketide synthase (PKS) systems are a rich source of structurally diverse polycyclic aromatic compounds with clinically relevant antibiotic and chemotherapeutic properties. The enzymes...

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SynBio Journal MDPI@SynBio_MDPIOct 5

🌱🧬 Could mathematical modelling help unlock faster-growing ANAMMOX bacteria for more efficient wastewater treatment? 📖Read more at: mdpi.com/2674-0583/2/1/5 #ANAMMOX #SyntheticBiology #MetabolicEngineering #SystemsBiology #Pangenomics #MetabolicModelling

Pangenome-Scale Mathematical Modelling of ANAMMOX Bacteria Metabolism

Removal of fixed nitrogen compounds such as ammonium and nitrite from wastewater is of critical importance for balancing the nitrogen cycle and protecting aquatic environments from eutrophication....

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SynBio Journal MDPI@SynBio_MDPISep 30

🧬🧠 Could kainate receptors reveal new mechanisms underlying schizophrenia? 📖 Read more at: mdpi.com/2674-0583/2/1/4 #CRISPR #CRISPRCas9 #Schizophrenia #Neuroscience #KainateReceptors #GRIK1 #GRIK2 #GRIK4 #Transcriptomics #Neurobiology #SyntheticBiology

Transcriptomic Investigation in CRISPR/Cas9-Mediated GRIK1-, GRIK2-, and GRIK4-Gene-Knockout Human...

The glutamate ionotropic kainate receptors, encoded by the GRIK gene family, are composed of four subunits and function as ligand-activated ion channels. They play a critical role in regulating...

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SynBio Journal MDPI@SynBio_MDPISep 29

🧬🧪 Could chemo-enzymatic approaches unlock new ways to build bioactive carbazole derivatives? 📖 Read more at: mdpi.com/2674-0583/2/1/2 #ChemoEnzymaticSynthesis #SyntheticBiology #Biocatalysis #Carbazoles #NaturalProducts #Biosynthesis #EnzymeEngineering #DrugDiscovery

Chemo-Enzymatic Synthesis of Bioactive Carbazole Derivatives

Carbazoles are key scaffolds of either antimicrobial/antiviral alkaloid natural products or therapeutics. As such, access to structurally diverse indole-containing carbazoles has attracted consider...

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SynBio Journal MDPI@SynBio_MDPISep 29

🧬🦠 Could studying NSP6 mutations help us better understand how SARS-CoV-2 Omicron variants evolve and evade host immunity? 📖Read more at: mdpi.com/2674-0583/3/2/7 #SARSCoV2 #Omicron #COVID19 #NSP6 #ViralEvolution #Virology #ComputationalBiology #SyntheticBiology

Functional and Evolutionary Characterization of the NSP6 Protein in SARS-CoV-2 Omicron Variants

The SARS-CoV-2 virus, which causes COVID-19, has rapidly evolved, producing highly transmissible variants like Omicron. Non-structural protein 6 (NSP6) is essential for viral replication and immune...

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SynBio Journal MDPI@SynBio_MDPISep 29

Meet us at the booth D05 at the Metabolic Engineering Summit 2026, 18–22 October 2026, in Dalian, China! 🤝 mdpi.com/journal/synbio/news…

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SynBio Journal MDPI@SynBio_MDPISep 25

🧬🤖 Could AI-based protein structure predictions reveal more than just static structures? 📖Read more at: mdpi.com/2674-0583/3/4/18 #AlphaFold3 #ChronoSort #ProteinEngineering #StructuralBiology #SyntheticBiology #MolecularDynamics #DrugDiscovery #ComputationalBiology

ChronoSort: Revealing Hidden Dynamics in AlphaFold3 Structure Predictions

Protein function emerges from dynamic conformational changes, yet structure prediction methods provide only static snapshots. While AlphaFold3 (AF3) predicts protein structures, the potential for...

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SynBio Journal MDPI@SynBio_MDPISep 23

🧬🧪 Could programmable expression systems make Aspergillus a more predictable and powerful microbial cell factory? 📖Read more at:mdpi.com/2674-0583/4/3/18 #Aspergillus #SyntheticBiology #MetabolicEngineering #ProteinProduction #IndustrialBiotechnology #MicrobialCellFactories

Engineering Programmable Expression Systems in Aspergillus: Genetic Architecture, Expression...

Aspergillus species combine eukaryotic protein processing, efficient secretion, and established industrial fermentation, making them important hosts for enzymes, food proteins, and natural products....

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SynBio Journal MDPI@SynBio_MDPISep 14

🧬💊 Could synthetic biology help push the boundaries of polyene antibiotic engineering and create less toxic antifungal compounds? 📖Read more at: mdpi.com/2674-0583/2/1/3 #SyntheticBiology #PolyeneAntibiotics #GlycosylationEngineering #NaturalProducts #Leishmania

Generation of New Glycoanalogues of Polyene Antibiotics by Synthetic Biology—Testing Current...

A number of antifungal drugs are based on polyene macrolides that cause severe side effects. Most of these compounds contain a single aminodeoxysugar, D-mycosamine. Toxicity can be reduced by...

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SynBio Journal MDPI@SynBio_MDPISep 8

🧬🌱 Could rationally designed genetic promoters unlock the full biotechnological potential of algae? 📖Read more at: mdpi.com/2674-0583/4/3/17 #Algae #Microalgae #SyntheticBiology #MetabolicEngineering #Biotechnology #GeneticEngineering #AlgalBiotechnology #Bioengineering

Synthetic Orthogonal Promoters and Transcription Factor Platforms in Algae: Rational Design...

Algae biomass and cellular exudated compounds have several biotechnological applications in various areas, such as agriculture, pharmaceutical, human and animal feed, and bioenergy, among others....

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SynBio Journal MDPI@SynBio_MDPIAug 27

🧬🌱 Could polyamines help unlock new strategies for optimizing microalgal growth and biotechnological production? 📖Read more at: mdpi.com/2674-0583/3/2/8 #Microalgae #Polyamines #MetabolicEngineering #SyntheticBiology #Biomass #SystemsBiology #AminoAcidMetabolism

Polyamine-Mediated Growth Regulation in Microalgae: Integrating Redox Balance and Amino Acids...

Polyamines play a pivotal role in regulating the growth and metabolic adaptation of microalgae, yet their integrative regulatory roles remain underexplored. This review advances a comprehensive...

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SynBio Journal MDPI@SynBio_MDPIAug 26

🧬🧫 Could synthetic biology help make stem cell therapies safer and more precisely programmable? 📖Read more at: mdpi.com/2674-0583/3/3/11 #SyntheticBiology #StemCells #GeneticCircuits #CellEngineering #RegenerativeMedicine #CellTherapy #MachineLearning #GeneticEngineering

A Guide in Synthetic Biology: Designing Genetic Circuits and Their Applications in Stem Cells

Stem cells, unspecialized cells with regenerative and differentiation capabilities, hold immense potential in regenerative medicine, exemplified by hematopoietic stem cell transplantation. However,...

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SynBio Journal MDPI@SynBio_MDPIAug 24

🧬☀️ Could cyanobacterial recombination systems make genetic engineering of Synechocystis more efficient? 📖Read more at: mdpi.com/2674-0583/4/3/16 #Cyanobacteria #Synechocystis #GeneticEngineering #SyntheticBiology #GenomeEngineering #Recombinase #MetabolicEngineering

Exploiting Cyanobacterial RecET Homologues to Improve Genetic Engineering Efficiency in Synechocy...

Cyanobacteria offer a sustainable and environmentally friendly method of light-driven biosynthesis of chemicals with minimal environmental impact, making them an extremely attractive proposition in...

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SynBio Journal MDPI@SynBio_MDPIAug 21

🧬🧪 Could virus-like particles make enzyme biocatalysts more stable, easier to produce, and simpler to purify? 📖Read more at: mdpi.com/2674-0583/3/1/5 #EnzymeEngineering #Biocatalysis #EnzymeStabilization #SyntheticBiology #ProteinEngineering #Biotechnology #QBetaVLP

Streamlined Production, Protection, and Purification of Enzyme Biocatalysts Using Virus-like...

Enzymes play an essential role in many different industries; however, their operating conditions are limited due to the loss of enzyme activity in the presence of proteases and at temperatures...

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SynBio Journal MDPI@SynBio_MDPIAug 20

🧬🦠 CRISPR/Cas9 could help overcome the challenges of engineering polyploid microbial cell factories. 📖Read more at: mdpi.com/2674-0583/3/1/3 #CRISPR #CRISPRCas9 #SyntheticBiology #GenomeEngineering #sgRNA #MetabolicEngineering #Biomanufacturing #Cyanobacteria

Design of an Effective sgRNA for CRISPR/Cas9 Knock-Ins and Full Mutant Segregation in Polyploid...

Synechocystis sp. PCC 6803 is a highly promising organism for the production of diverse recombinant compounds, including biofuels. However, conventional genetic engineering in Synechocystis presents...

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SynBio Journal MDPI@SynBio_MDPIAug 14

🌊🤖 Could the convergence of AI and synthetic biology unlock the next generation of smart marine biotechnology? 📖Read more at: mdpi.com/2674-0583/4/3/15 #MarineBiotechnology #Macroalgae #SyntheticBiology #BioactiveCompounds #MetabolicEngineering #FunctionalFoods #Biotechnology

Smart Marine Biotechnology: Integrating AI and Synthetic Biology for Macroalgal Bioactive Compound...

Marine macroalgae represent abundant, renewable reservoirs of structurally unique bioactive compounds, such as sulfated polysaccharides, phlorotannins, and carotenoids, with immense potential for...

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SynBio Journal MDPI@SynBio_MDPIAug 12

🌱🧬 Could synthetic biology help plants adapt to a changing climate and strengthen crop protection? 📖Read more at: mdpi.com/2674-0583/4/1/1 #SyntheticBiology #PlantImmunity #CRISPR #RNAInterference #ClimateResilience #CropProtection

Programmable Plant Immunity: Synthetic Biology for Climate-Resilient Agriculture

Agricultural systems face mounting pressures from climate change, as rising temperatures, elevated CO2, and shifting precipitation patterns intensify plant disease outbreaks worldwide. Conventional...

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