@SwastiLab

Protein Homeostasis & Proteomics Lab headed by Dr. Swasti Raychaudhuri Account managed by Lab members

 CSIR-CCMB
e-portal.ccmb.res.in/e-space/swasti/index.htm
Joined October 2023
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  • Followers82
64Media
DDX39A unwinds viral RNA G-quadruplexes to limit α-Synuclein amyloidogenesis dlvr.it/TVf7DH

DDX39A unwinds viral RNA G-quadruplexes to limit α-Synuclein amyloidogenesis

Jain et al. demonstrate that RNA helicase DDX39A regulates α-Synuclein amyloidogenesis by unwinding RNA G-quadruplexes (rG4s) and that viral rG4s accelerate this aggregation by perturbing α-Synucle...

cell.com
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Interesting: @SwastiLab reports that mRNA G-quadruplexes-dependent interactions with the DEAD-box helicase DDX39A decelerates α-Synuclein amyloidogenesis. Interupting interactions between α-Syn & DDX39A⬆️amyloidogenesis, while over-expressing DDX39A⬇️it cell.com/cell-reports/fullte…
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Is viral infections a ticking clock for Parkinson's disease? Our lab shows that Viral RNA can fuel α-Synuclein amyloidogenesis -but DDX39A fights back by unwinding the RNA G-quadruplexes. Kudos to @Aanchal77521343 and @rcswasti cell.com/cell-reports/fullte… @ccmb_csir @AcSIR_India

DDX39A unwinds viral RNA G-quadruplexes to limit α-Synuclein amyloidogenesis

Jain et al. demonstrate that RNA helicase DDX39A regulates α-Synuclein amyloidogenesis by unwinding RNA G-quadruplexes (rG4s) and that viral rG4s accelerate this aggregation by perturbing α-Synucle...

cell.com
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Huge congratulations to @Guptapooja_28 on being awarded her doctorate! 🎓🎉
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Dr. Amitabha Majumdar ends the session with his findings uncovering a mechanistic link between condensates, transcriptional regulation, development, and disease. #EMBOCCMB25 @EMBO @ccmb_csir
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Prof. Dr. Manish Jaiswal uncovering how a developmentally programmed mechanism links membrane tubulation, fission & fusion to mitochondrial remodeling — showing how dynamic organelle architecture is coupled to cell fate. #EMBOCCMB25 @EMBO @ccmb_csir
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Solving mystery: Dr. Dhanasekaran Shanmugam is sharing insight into how Toxoplasma gondii exploits metabolic flexibility to survive the loss of its entire apicoplast, revealing crucial vulnerabilities for anti-parasitic drug development! #EMBOCCMB25 @EMBO @ccmb_csir
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BIG IDEAS ALERT-The parasite's PQC machinery is fundamentally different from ours! Dr. Niti Kumar shows how these diverged components are key to maintain homeostasis under stress and are now prime targets for drug development to minimize resistance. #EMBOCCMB25 @EMBO @ccmb_csir
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FEEL THE EXCITEMENT: @kausikigib reveals a surprising link in S. cerevisiae: loss of mtDNA activates a cryptic interorganellar cooperation to combat proteotoxicity. This mechanism enhances protein quality control degradation! #EMBOCCMB25 @EMBO @ccmb_csir
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Tune in! @omc111 is demonstrating how liquid-liquid phase separation (LLPS) creates specialized organelles required for efficient CO₂ fixation. Understanding this spatial compartmentalization is guiding efforts to engineer higher-performing crops! #EMBOCCMB25 @EMBO @ccmb_csir
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HIGH-RES DISCOVERY: Prof. Dr. Markus Schwarzländer shows how biosensor-based live imaging is uncovering the unique way plant organelles act as mobile response entities, underpinning the metabolic flexibility of the chloroplast/mitochondria axis! #EMBOCCMB25 @EMBO @ccmb_csir
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Happening now! @Santosh_CCMB is discussing his recent findings on Initial events of inhibitory signaling in human natural killer cells! at #EMBOCCMB25 @EMBO @ccmb_csir
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INSIGHTS FLOWING: The dynamic interactions between biomolecular condensates and membranes—a crucial defense mechanism—are now being revealed by @claudiobussi at #EMBOCCMB25 @EMBO @ccmb_csir
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Grab a seat! Listen to @MahakSharma23 appreciating the role of small G protein Arl8b in lysosome biogenesis and highlighting its necessity for the proper function of the endosomal retrieval system at #EMBOCCMB25 @EMBO @ccmb_csir
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Starting #EMBOCCMB25 Day4 with Prof. Dr. Janine Kirstein presenting her work on regulation of amyloid proteins of Huntintington's diseases and an active chaperone complex formation that surprisingly changes HTT fibril structure, driving secondary nucleation. @EMBO @ccmb_csir
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A flash talk being delivered by our lab member @Aanchal77521343 at #EMBOCCMB25 @csir_ccmb @EMBO
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Get ready to dive into mitochondrial dynamics! Our speaker @Oishee_Chak is here at #EMBOCCMB25 to reveal the molecular mechanism preventing destructive hyperfusion, focusing on the critical role of the endoplasmic reticulum. @EMBO @ccmb_csir
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NEW MECHANISM ALERT: @richa_rikhy showing insights in to mitochindrial fission as a crucial step in the regulation of morphigenesis, harnessing mitochondrial dynamics in Drosophila gastrulation. #EMBOCCMB25 @EMBO @ccmb_csir
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Science, Smiles & Synergy at #EMBOCCMB25 @ccmb_csir @EMBO
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Currently Prof. Nora Vögtle is walking us through the pathophysiological consequences of disease mutations and how the cell deals with dysfunction in the cellular powerhouse. #EMBOCCMB25 @EMBO @ccmb_csir
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