Thank you @DrSidMukherjee for taking the time out of your busy schedule to visit @SwantonLab @WillHilliam @DrClareWeeden @CharlesSwanton to talk about our work on air pollution and lung cancer @TheCrick

Published today @FrontOncology: Phenotyping of CD45+ xenografts from the TRACERx lung cancer patient-derived xenograft (PDX) study. IgL/IgK restriction suggests primary tumours can contain multiple B cell clones with lymphoproliferative potential. doi.org/10.3389/fonc.2023.11…

Congratulations to Dr Dhruva Biswas from @SwantonLab who successfully passed his viva this afternoon.

Huge congratulations to Dr Aska Przewrocka @PrzeAska who successfully defended her thesis.

Huge congratulations to @SwantonLab clinical fellow @drmaiseb who successfully passed her viva. #dr_dr. Well done.

cancer-types. This may mean that identifying histology-specific clonal biomarkers could be useful in future work, and may provide a strategy to refine biomarker design in other cancer types.

in proliferation genes might contribute to poor clinical outcome.

in a particular tumour region, drives a corresponding increase in expression of the amplified genes.

expression signature of tumour aggressiveness and metastatic potential.

ORACLE had a significant survival association with a hazard ratio of 3.5. Importantly, in a multi-variate analysis this survival association was independent of known clinical risk factors, indicating ORACLE provides orthogonal molecular information.