Assistant Professor @MGH_RI and @harvardmed studying how the progression of Alzheimer's Disease leads to neuronal dysfunction. https://xitter.cf/t.co/OWm7U88VXE

Joined October 2014
#Twophotonmicroscopy & image analysis provides insight into relationship between #tau neurofibrillary tangles & #neurons in #Alzheimers mice model & human tissue. Image & research by @Stray_Scientist et al @MGH_RI @harvardmed in @CellReports. On bpod.org.uk/archive/2024/9/2
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In Alzheimer's the presence of neurons with tau tangles is a close correlate for neuron loss BUT in new 2P longitudinal imaging work from the lab we show that neurons with tangles live while neurons without tangles die. I'm surprised, are you? @MGH_RI : cell.com/cell-reports/fullte…
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In people w/ Alzheimer's, blood vessels are tortuous and irregular just like what we reported in tau models in 2018. In our new work, we show that there's a lot more perivascular tau than previously thought. Read about clear brains + vascular tau here: link.springer.com/article/10…
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In a recent study published in the Journal of Brain, Behavior, and Immunity, researchers from @MGHNeurology and colleagues investigated MS and synapse damage from inflammation. Read more: massgeneral.org/news/researc… @mghneurosci
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Invisible tau and shunned neurons? A little teaser for work we have been doing with Brad Hyman and Ted Zwang. More to come soon (I hope)! alzforum.org/news/research-n…
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