We translate research to improve care for patients with autoimmunity, infectious diseases, and conditions requiring transfusion or transplantation.
BWH/HMS
Joined July 2023
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I don’t post very often, but I couldn’t help sharing the experience that led to this paper, published earlier this week. (science.org/doi/10.1126/scit…)
During my first year of residency, I was involved in the care of a patient with sickle cell disease who experienced a severe transfusion complication. Despite heroic efforts by many involved, he eventually succumbed. His case was unfortunately not unique. Other patients with sickle cell disease suffered similar fatal transfusion complications. These experiences completely changed the trajectory of my career. It was during this time that I was incredibly fortunate to meet Satheesh Chonat, one of the most impressive physician-scientists I have ever had the chance to work with and someone who has become a lifelong friend and colleague. Building on a critical research infrastructure established by Solomon Ofori-Acquah, Olufolake Adisa, and Ross Fasano, Satheesh and I, along with many others, set out to understand the underlying factors that may contribute to some of the most severe complications patients with sickle cell disease experience. That was over 10 years ago. The manuscript below is a product of work that started then, made possible by the participation of many patients and investigators. While many more studies are certainly needed, we hope these data contribute to the ongoing incredible work by many of our wonderful colleagues, including Lubka Roumenina, Pablo Bartolucci, France Pirenne, Solomon Ofori-Acquah, Greg Vercellotti, Karina Yazdanbakhsh, Robert Brodsky, among others, examining the role of complement in the pathogenesis of sickle cell disease. Perhaps these collective studies, and others like them, will identify better ways to manage complications that patients with sickle cell disease unfortunately experience.
#ASH_hematology
#AABB
#ATLPedsHemOnc
Mass General Brigham highlight: massgeneralbrigham.org/en/ab…
Plasma donation plays a major role in modern medicine. Despite this, the journey from donor to life-saving therapy, as well as the difficulties of donor recruitment and retention, are often left undiscussed. #donateplasma #plasmaawareness onlinelibrary.wiley.com/doi/…
Sean Stowell lab retweeted
Joy is everywhere at #ASH24 🩸 It's in the exchange of ideas — from session rooms to dinner conversations — in the reunions we cherish each year, and in celebrating our colleagues' incredible achievements. Every moment feels special and fun, and some are unexpected! 🐶🦄
Sean Stowell lab retweeted
New in #Transfusion:
Investigators surveyed U.S. institutions to explore lab testing practice for individuals with fetuses at risk of hemolytic disease of the fetus and newborn.
Read the open-access study: bit.ly/3YH0zCd
#HDFN #Transfusion
Congratulations to all of the lab members who worked hard on this recent review shedding light on the fascinating interplay between ABO blood groups & galectins! #TransfusionMedicine #Immunology #Galectins #ABOAntigens
pubmed.ncbi.nlm.nih.gov/3940…
📽️ Check out this video on how galectin proteins help the immune system target bacteria that disguise themselves with 'self' antigens! 🦠🐑 #Immunology #TransfusionMedicine #Galectins youtu.be/0YSFypiZFLQ?si=SNkF… via @YouTube
New in @BloodJournal: Nguyen et al. show CORM-401, a CO-releasing molecule, can reduce hemolysis-induced endothelial injury in sickle cell disease, offering a potential new treatment for acute SCD complications sciencedirect.com/science/ar…
Congratulations to Dr. Ryan P. Jajosky on receiving this grant for his work on KEL alloimmunization in transgenic mice models! This project is paving the way for safer #bloodtransfusions and a better understanding of #alloimmunity. 🎉
Drumroll please! 🥁
The AABB Foundation is pleased to introduce the 2024 early-career scientific research grant recipients. Learn more about these promising investigators and their AABB Foundation-supported research projects.
👉 bit.ly/3VkxARL
#Research #AABBFamily
Congratulations to @Shang_Chuen_Wu, @Justin_Jan_4928, and other members of our lab for their recent publication on the dimeric nature of galectin-4! #galectin #glycobiology #Immunology
pubmed.ncbi.nlm.nih.gov/3849…
Happy #NationalPostdocAppreciationWeek! 🎉 Postdocs are the backbone of groundbreaking research, pushing the frontiers of science and knowledge every day. Thank you for your dedication, resilience, and passion! 🌟 #PostdocPride #ResearchHeroes
This summer, we hosted students from @BYU @EmoryUniversity @BU_Tweets @UCSanDiego and co-ops from @Northeastern who all gained experience in glycobiology and transfusion medicine. We will miss them and wish them luck as they begin their fall semesters!
In honor of #SickleCellAwarenessMonth we are spotlighting this review that discusses the difficulty surrounding alloimmunization during patient treatment. #bloodtransfusion #gettoknowsicklecell #sicklecell @BloodHealthEd pubmed.ncbi.nlm.nih.gov/3798…
Did you know that the severity of your #covid19 infection could be affected by your blood type? As we are seeing spikes in COVID-19 cases, it is relevant to bring up this article published with Dr. Connie M. Arthur and Dr. Richard D. Cummings.
pubmed.ncbi.nlm.nih.gov/3794…
It's great to attend the 2023 SFG meeting in Hawaii, and congratulations to @DoMorais_ and @Shang_Chuen_Wu on receiving the SFG travel award.
Congratulations to Dr. Ryan Philip Jajosky on getting his paper published. Hopefully, our proposed treatment will be utilized to help malaria patients.
mdpi.com/2414-6366/8/10/478
Congratulations to Rebecca Hale and @DoMorais_ Dominique Morais for their excellent contribution in reviewing glycosylation in clinical allergy and immunology. pubmed.ncbi.nlm.nih.gov/3771…
Sean Stowell lab retweeted
Galectin-1 a targetable checkpoint in human cancers? Here we show that Galectin-1 induces tumor-associated like macrophages with increased expression of IDO1 and PD-L1 in human cancers. sciencedirect.com/science/ar…
ALT Galectin-1 (green) expression in 3D organotypic models of HRAS positive invasive tumors.
Congrats to Mischa!! pubmed.ncbi.nlm.nih.gov/3760…
It was great to visit @glyco26 held at Academia Sinica in Taiwan, which is amazing. Congratulations to @Shang_Chuen_Wu Peter for receiving the Glyco26 Poster Awards and delivering a wonderful oral presentation.
Acknowledging and thanking my lab members and collaborators for their invaluable contributions.
xitter.cf/SFGlycobiology/status/…
🚨 2023 SFG Awardees 🏆!!
Glycobiology Significant Achievement Award: Dr. Matthew Macauley @MatthewMacaule4(University of Alberta @UAlberta) and Dr. Sean Stowell @Stowell_lab (Harvard Medical School @HMSCfG)
Congratulations!!