@StirlingLab

Located in the Terry Fox Laboratory, BCCRC, Vancouver BC. Translational research in genome integrity maintenance, using budding yeast and human cell line models

 Vancouver
terryfoxlab.ca/
Joined March 2014
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  • Following108
  • Followers367
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Replying to @StirlingLab
@StirlingLab @kyyjiang Kate - check it out!
Peter Stirling@pcstirling17 Jun 2020
Short and sweet one from @VeeLib and others to @biorxivpreprint biorxiv.org/content/10.1101/…

Cdc48 regulates intranuclear quality control sequestration of the Hsh155 splicing factor

Cdc48/VCP is a highly conserved ATPase chaperone that plays an essential role in the assembly or disassembly of protein-DNA complexes and in degradation of misfolded proteins. We find that Cdc48...

biorxiv.org
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Replying to @StirlingLab
@StirlingLab
Mark Richardson@slavetothehat11 May 2020
I work for the Canadian federal government and they sent out an email with work at home guiding principles. It’s amazing to work for a place that speaks like this.
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Thrilled to share our latest paper in @NatureComms Great collaboration with @HieterLab @koborlab @JeanYvesMasson. Building on the #APOYG we really get into replication-transcription conflicts in human cell lines for the first time - now we are hooked! nature.com/articles/s41467-0…
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Woo! Amazing grad student Annie Tam @StirlingLab mini review
🔬 R-loop@R_loop_papers7 Apr 2019
Splicing, genome stability and disease: splice like your genome depends on it! dlvr.it/R2LHXt
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Thanks again for prelighting our work! @StirlingLab
Kate Weiner Miller@katieweiner1021 Jan 2019
Excited to join the preLights community highlighting new and exciting preprints! Did you know the MRN complex does more then just double strand break repair? Check out my first highlight to find out how else it protects our genome: bit.ly/2MmFlnH
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Check out this new review on chromatin and DNA replication stress from @lfournier7 Arun Kumar and I from @StirlingLab mdpi.com/2073-4425/9/12/622/… Great work guys!
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Online early today @MBoCjournal from my lab. molbiolcell.org/doi/abs/10.1… Great job Annie Tam (and team)! Basically we find that it is not ALL about R-loops. Low tubulin levels explain most CIN in yeast splicing mutants (some make R-loops too).

Selective defects in gene expression control genome instability in yeast splicing mutants |...

Mechanisms of genome instability in yeast splicing mutants are identified. It is found that altered expression of tubulin may be a general source of mitotic defects. The data also suggest that some...

molbiolcell.org
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Check out the recent work from the @StirlingLab
🔬 R-loop@R_loop_papers18 Nov 2018
MRE11-RAD50-NBS1 activates Fanconi Anemia R-loop suppression at transcription-replication conflicts dlvr.it/QrVnFf
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Congrats @CIHR_IG & @Dalnews on launch of the Institute of Genetics at its new location - proud to be a member of the Board and looking forward to a productive future! @cyclocrossguy @BethPotter4 @guilbourque @EstherVerheyen @kalle_gehring @StirlingLab medicine.dal.ca/news/2018/10…

Newly‑launched Institute of Genetics a first for Atlantic Canada

medicine.dal.ca
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Thrilled to be representing the @StirlingLab and presenting our data involving R-loop regulation with MRN, ARID1A and PCNA at the EMBO Workshop in Mainz, Germany @imbmainz
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Related: we are looking for outstanding postdocs and graduate students to work on R-loops, Replication-transcription conflicts, hypermutation signatures, and cancer. See more: terryfoxlab.ca/people-detail…
Peter Stirling@pcstirling22 Aug 2018
Replying to @StirlingLab @CCSResearch
Yes, incredibly exciting morning. I am really honoured that our work has been recognized and will be working hard to ensure that we live up to our plans. Thank you @CCSResearch for the opportunity!
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Stirling Lab retweeted
Hieter Lab@HieterLab23 Aug 2018
Congratulations @philhieter
Genetics Society of America@GeneticsGSA23 Aug 2018
To cap off the evening, #GENETICS Editor in Chief @mjohn1251, on behalf of the GSA Board of Directors, presents the 2018 GSA George W. Beadle Award to @philhieter. #Yeast18 genestogenomes.org/genetics-…
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Replying to @StirlingLab @CCSResearch
Yes, incredibly exciting morning. I am really honoured that our work has been recognized and will be working hard to ensure that we live up to our plans. Thank you @CCSResearch for the opportunity!
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Incredibly grateful to be awarded a @CIHR_IRSC project this morning. Really excited for the work it enables and the great people in my lab who can breath easy for a while. Thank you!
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Wow, this bot really works - we just posted this sort on BioRxiv - link to follow xitter.cf/r_loop_papers/status/9…
🔬 R-loop@R_loop_papers28 Feb 2018
New #Rloop paper: The yeast core spliceosome maintains genome integrity through R-loop prevention and alpha-tubulin expression dlvr.it/QJBB9R
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Stirling Lab retweeted
Hieter Lab@HieterLab22 Dec 2017
Our collaboration with @DrT1973 is up at @genomeresearch. Whole genome assembly of C. elegans from MinION reads. genome.cshlp.org/cgi/content…
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Excited to talk about @StirlingLab science and genome instability at U Ottawa today! Thanks CMM! @DowneyUOttawa @uOttawaBMI @CMMNSCGSA
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RECQ-like helicases Sgs1 and BLM regulate R-loop–associated genome instability jcb.rupress.org/content/earl… @StirlingLab
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Chang et al. link the RECQ-like helicase BLM to preventing DNA damage caused by R-loops jcb.rupress.org/content/earl… @StirlingLab
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RECQ-like helicases Sgs1 and BLM regulate R-loop–associated genome instability jcb.rupress.org/content/earl… @StirlingLab
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