Kids with severe heart defects often need surgery after surgery because their repair parts can't grow. Boston's new THUMPIN' project (up to $29.6M) aims to build living valves, vessels and patches that grow with a child, and one day a whole heart. seas.harvard.edu/news/boston…
Money from the world’s increasingly prosperous technology entrepreneurs has been flooding into biomedical research. Is it changing how science is done?
go.nature.com/4sfUkDV
The first patient to get RiHeart, a heart muscle patch grown from iPS stem cells, is recovering well. A week after surgery she could breathe deeper, and she goes home Oct 22. Think of it as a living bandage that helps a tired heart grow new blood vessels.
Patient recovering well after iPS heart sheet surgery in Japan english.kyodonews.net/articl…
Source: Patient recovering well after iPS heart sheet surgery in Japan (Kyodo News) english.kyodonews.net/articl…
Lab grown heart muscle clusters helped monkey hearts pump better 3 months after a heart attack. Next goal: make them from a patient's own blood cells, so no lifelong immune drugs.
Source: Human iPSC cardiomyocyte aggregate cell therapy in non human primates and correlation of heart recovery with contractile and electrophysiological cardiomyocyte properties (Nature Communications) nature.com/articles/s41467-0…
In 6 days, 7 chemicals turned about half of human stem cells in a dish into cells like those of an 8 cell embryo. Like rewinding a movie to its first scene, these cells can help build both body and placenta. The old way took 3 weeks (Cell Research). scienmag.com/seven-chemical-…
Old Blood Cells Have Been Transformed Into Brain Stem Cells That Get Younger As They Age
sciencealert.com/old-blood-c…
Stem cells by the back roads: Miami doctors got FDA clearance to send donor stem cells through the small arteries feeding painful arthritic knees, not just into the joint.
FDA Authorizes Novel Clinical Trial Exploring Artery Delivered Stem Cells for Knee Osteoarthritis news.med.miami.edu/artery-de…
Switching off one gene helped lab grown heart cells hide from the immune system. Japanese scientists turned off TAPBP in stem cells, so the heart cells show fewer ID tags. In lab tests, killer T cells attacked far less, and NK cells left them alone. doi.org/10.1016/j.isci.2026.…
Heart muscle cells made from stem cells stuck better to damaged rat hearts after a 1 hour coating. It adds a tiny hook that grabs frayed collagen in heart attack scars, like Velcro. Over 6 weeks, those hearts pumped stronger and kept their shape. doi.org/10.1016/j.bioactmat.…
This week in stem cells:
○ Japan fully approved Stemirac, a bone marrow stem cell therapy for spinal cord injury.
○ Gene edited blood stem cells helped mice with Friedreich's ataxia walk better.
○ Hormones set the pace of skin stem cells, so female mice healed faster.
One infusion of gene edited blood stem cells helped mice with Friedreich's ataxia walk better and kept their brain, heart and insulin cells healthier.
Edited HSPCs rescue frataxin deficiency and inflammation driven multisystemic pathology in Friedreich's ataxia mice (JCI) jci.org/articles/view/209546
Japan's health panel cleared full approval for Stemirac, a patient's own bone marrow stem cell therapy for spinal cord injury. It is the first regen medicine product there to graduate from provisional status after more efficacy data confirmed the benefit.
hokkaido-np.co.jp/article/13…
A gel ark of disc stem cells plus a cleanup crew for damaged cell power plants rebuilt worn spinal cushions in rats and restored their bounce.
Source: Progenitor cell ark restores spinal disc structure and bounce in rats science.org/doi/10.1126/scia…
Giant dogs lose the chemical locks on their jumping genes (DNA bits that copy themselves around) about 35% faster each year than small dogs, which may help explain why they die younger. In 864 dogs, ASU scientists found these locks wear off with age. ynetnews.com/environment/art…
Skull holes too big to heal on their own repaired better in rats given 3D printed mini bones made with aloe vera. The plant gel acted like a coach for immune cells, moving them from fight mode to repair mode while stem cells laid down new bone (iScience). scienmag.com/aloe-vera-bioin…






