@SportsGenomics

Reader in Genetics & Epigenetics @LJMUSportSci Sports genomics ∙ Muscle ∙ Sarcopenia ∙ Ageing ∙ Longevity ∙ Obesity ∙ Nutrition ∙ Behavioural genomics ∙ Talent

 Liverpool, England
researchgate.net/profile/Ildus_Ahmetov
Joined October 2015
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  • Followers610
26Media
Delighted to see our paper published in @NatureComms! We identified EDA2R as the top gene linked to aging across all human tissues, acting as both a biomarker of inflammaging and a driver of aging. @LJMUSportSci nature.com/articles/s41467-0…

Increased ectodysplasin-A2-receptor EDA2R is a ubiquitous hallmark of aging and mediates parainfl...

Nature Communications - In a broad cross-tissue analysis, the authors show that a receptor called EDA2R steadily increases with age in both humans and animal models, and becomes even more active in...

nature.com
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A proteomic signature of freeze-resistance, training status and skeletal muscle mass. tandfonline.com/doi/full/10.…

Trait-like proteomic signatures of stress resilience: correlates of freeze-like response resistance

The freeze-like response is a fundamental defensive mechanism that remains poorly understood despite its potential to impair functioning under acute threat. We examined its biological correlates us...

tandfonline.com
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Out in @BiolSport: A genetic profile associated with greater resilience to sports-related injuries may increase an athlete’s chances of reaching elite performance levels. termedia.pl/The-genetic-land…
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51 genes can distinguish exercise-trained from sedentary muscle cell.com/cell/fulltext/S0092…

Multi-omics atlas of chronic exercise

A 22-tissue multi-omics atlas of chronic exercise is generated, detailing tissue-, sex-, and time-dependent molecular adaptations and cell-type-specific epigenetic remodeling in skeletal muscle. The...

cell.com
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Systemic proteomic dynamics of acute exercise reveal genetic links to health and disease nature.com/articles/s42255-0…

Systemic proteomic dynamics of acute exercise reveal genetic links to health and disease

Nature Metabolism - This study provides a comprehensive, systems-level characterization of acute exercise-induced proteomic responses across several body fluids in humans.

nature.com
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Higher total physical activity and lower insulin resistance are both associated with higher proportions of Type 1 nuclei and lower proportions of Type 2x nuclei. cell.com/iscience/fulltext/S…

Inverse directions of association of higher physical activity and higher insulin resistance with...

Musculoskeletal anatomy; Endocrinology; Physical activity; Human metabolism; Molecular biology; Transcriptomics

cell.com
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GWAS identifies 620 genetic variants associated with fluid intelligence. nature.com/articles/s41588-0…

Imputation of fluid intelligence scores reduces ascertainment bias and increases power for analyses...

Nature Genetics - Imputing unmeasured fluid intelligence scores in UK Biobank reduces ascertainment bias and increases power for genetic analyses, improving out-of-sample polygenic score...

nature.com
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The more polluted the air, the fewer papers scientists publish nature.com/articles/s41562-0…

Impacts of PM2.5 air pollution on high-skilled worker productivity in China

Nature Human Behaviour - Dong, Qiao and Zhou show how variations in the level of air pollution impact the productivity of scholarly researchers in China.

nature.com
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Multiomics profiling identifies molecular and cellular signatures of regular exercise in human peripheral blood science.org/doi/full/10.1126…

Multiomics profiling identifies molecular and cellular signatures of regular exercise in human...

Regular exercise is well established to protect against metabolic disorders and bolster immunity, but the underlying molecular and cellular mechanisms remain incompletely understood. We integrated...

science.org
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151 genes linked to strength preservation during calorie restriction-induced weight loss onlinelibrary.wiley.com/doi/…

Biological Pathways of Strength Preservation During Calorie Restriction‐Induced Weight Loss Among...

Analysis workflow for identifying strength-associated pathways and genes using the CALERIE data set.

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Mitochondrial DNA alterations in muscle stem cells drive glycolytic-to-oxidative myofiber shift cell.com/cell-reports/fullte…

mtDNA alterations in muscle progenitors determine myoblast differentiation and disrupt skeletal...

The role of mtDNA integrity in muscle progenitor function remains poorly understood. Sen et al. show that mtDNA alterations in myoblasts impair myogenic differentiation and reshape the mitochondrial...

cell.com
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Sex- and fiber type-specific remodeling of the human skeletal muscle proteome following 8 weeks of resistance training nature.com/articles/s41467-0…

Sex- and fiber type-specific remodeling of the muscle proteome implicates CSRP3 in resistance...

Nature Communications - Here, the authors show that changes in the muscle fiber proteome following 8 weeks of resistance training are both sex- and fiber type-specific. This includes greater...

nature.com
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Genome-wide association study of sarcopenia index link.springer.com/article/10…

Genome-wide association study of sarcopenia index reveals sex-stratified genetic architecture

Biology of Sex Differences - The sarcopenia index (SI), defined as the ratio of serum creatinine to cystatin C, is a proposed biomarker of muscle mass and sarcopenia, yet its genomic basis and...

link.springer.com
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A recent study reports nearly 100% MHC-I (slow) fibres in an ultra-endurance runner. onlinelibrary.wiley.com/doi/… We observed the same phenotype in a male 2:30 h marathoner, whose slow-fibre proportion increased from 61.6% to 100% over 7 years.

Musculoskeletal (Mal)adaptations in Response to a > 30 000‐km Running Challenge

Background Ultra-endurance sports are increasingly popular, yet the long-term physiological consequences of sustained extreme training loads remain poorly understood. In particular, the effects of...

onlinelibrary.wiley.com
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This runner also carries the CDKN1A rs236448 AA genotype (frequency: 14% in EUR), previously associated with a greater potential for an increased proportion of slow-twitch muscle fibres. pmc.ncbi.nlm.nih.gov/article…

Genome-Wide Association Study Identifies CDKN1A as a Novel Locus Associated with Muscle Fiber...

Muscle fiber composition is associated with physical performance, with endurance athletes having a high proportion of slow-twitch muscle fibers compared to power athletes. Approximately 45% of muscle...

pmc.ncbi.nlm.nih.gov
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Ancestry-stratified GWAS identified 5,875, 945, 312, 702, and 79 independent BMI variants for European, African, Admixed American, East Asian, and South Asian groups, respectively (p < 1.0 × 10⁻⁵). Polygenic risk for BMI predicts future weight gain. link.springer.com/article/10…

A multi-ancestry polygenic risk score for body mass index predicts longitudinal weight change

Genome Medicine - Identifying individuals at risk for future weight gain is challenging, partly because associations with traditional clinical risk factors may be biased by confounding and reverse...

link.springer.com
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A transcriptomic map of human skeletal muscle for cell-type identification thelancet.com/journals/ebiom…

An integrated reference atlas of human skeletal muscle

This integrated reference atlas and accompanying annotation tool establish a standardised framework for human muscle transcriptomics, promoting consistent cell-type assignment and providing a...

thelancet.com
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A genome-wide association study identified 79 genetic variants associated with muscle fat infiltration. onlinelibrary.wiley.com/doi/…

Integrative Analysis Uncover the Effects and Multi‐Omics Features of Thigh Muscle Fat Infiltration

Thigh muscle fat infiltration (TMFI), estimated from MRI, is associated with increased mortality and diseases affecting multiple organ systems and mediates the effects of lifestyle factors on...

onlinelibrary.wiley.com
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Higher testosterone is associated with greater fertility but shorter lifespan in men. pubmed.ncbi.nlm.nih.gov/4260…

Mendelian randomization investigation into testosterone's trade-offs between longevity and reprod...

Our findings in men are consistent with antagonistic pleiotropy, i.e. higher testosterone was associated with greater fertility but shorter lifespan.

pubmed.ncbi.nlm.nih.gov
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Blood expression of TG, THAP8, and ERRFI1 genes is linked to faster skeletal muscle ageing, while WASF2, TBC1D3L, and TBXA2R genes are associated with slower ageing. nature.com/articles/s41591-0…

Histological aging signatures for monitoring tissue-specific aging and disease

Nature Medicine - Whole-slide histopathological images from 40 tissue types reveal morphological changes associated with aging, which, when paired with transcriptomic data from blood, are used to...

nature.com
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Ildus I. Ahmetov retweeted
GeroScience
@GeroScienceAGEJul 16
🧬💪 New in GeroScience Telomere length and appendicular lean mass over six years in older adults with overweight or obesity and metabolic syndrome: a prospective cohort study Héctor Vázquez-Lorente and colleagues found that longer baseline telomere length was associated with better preservation of appendicular lean mass over six years, supporting telomere length as a potential biomarker of healthy muscle aging in older adults with metabolic syndrome. 📖 Read the full article: rdcu.be/ft68W #GeroScience #MuscleAging #Telomeres #Sarcopenia #HealthyAging #MetabolicHealth #AgingResearch
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