Terrific session dedicated to the memory of Angelika Amon, with a tribute by @JSheltzer and outstanding talks by @JSheltzer, @ZStorchova, @SteSantaguida and others. #ANESRC

Terrific session dedicated to the memory of Angelika Amon, with a tribute by @JSheltzer and outstanding talks by @JSheltzer, @ZStorchova, @SteSantaguida and others. #ANESRC

Excited to welcome aneuploidy scientific community in sunny Melbourne, FL. Can't wait to see everyone. #ANESRC

Because CDK5 is overexpressed in many cancers and is associated with a poor prognosis, our study raises the possibility that these cancers may be more dependent on CDK5 for their cell division and suggests that CDK5 may be an important therapeutic target.

The study alters the existing paradigm that CDK1-Cyclin B1 is the only CDK-cyclin complex essential for all stages of mitosis and raises the possibility that other atypical CDKs may also have a role in regulating the cell-division cycle.

Loss of CDK5-Cyclin B1 interaction abolished CDK5 activity in vitro (thanks to our collaborator Kavita Shah) and phenocopied CDK5 abrogation in mitosis. CDK5–cyclin B1 is thus a canonical CDK–cyclin complex that plays an essential role in maintaining genome integrity.

Surprisingly, we discovered that CDK5 forms a functional complex with Cyclin B1, the mitotic cyclin that partners with CDK1 to complete all stages of mitosis.

With the help of our collaborator @AmandaPaulovich, we used phosphoproteomic analysis to identify putative CDK5 substrates that may account for this phenotype.

Using two orthogonal chemical genetic approaches, we show that CDK5, an atypical CDK essential in non-dividing neuronal cells, plays an important role in mitosis in preventing mitotic errors. Abrogation of CDK5 prior to mitosis led to chromosome mis-segregation and nuclear atypia

We found that these errors occur because spindle microtubules that separate sister chromatids during mitosis become abnormally stable in the absence of CDK5, preventing cells from correcting chromosome attachment errors.

Cyclin Dependent Kinases (CDKs) are critical for regulating different phases of the cell cycle and CDK1 was considered to be the only CDK essential mitosis.

(1/5) I am delighted to share our study published today @Nature nature.com/articles/s41586-0… collaboration with @Chowdhury Lab, led by @XiaoZheng3and @aniruddhSark. Huge congratulations to all the authors and collaborators.

#ANEUPLOIDY22 It was truly a fantastic meeting and a wonderful tribute to Angelika. Thank you @SteSantaguida, @JSheltzer, Eduardo Torres and Beth Weaver for making this possible. Hoping to see everyone again in 2 years.