@SoftSarcoma

Our goals are to understand the biology of pediatric sarcomas, generate new models and provide better therapeutic strategies for sarcoma patients.

 Heidelberg, Germany
dkfz.de/en/weichteilsarkome/index.php
Joined October 2019
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  • Following409
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6Media
A critical gap in sarcoma research has been the lack of flexible immunocompetent models. Here we show that efficient somatic gene delivery to mouse muscle enables to faithfully model various sarcomas in mice. Check out our new preprint👇
bioRxiv@biorxivpreprint1 Feb 2024
Somatic gene delivery for flexible in vivo modeling of high-risk sarcoma biorxiv.org/cgi/content/shor… #bioRxiv
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Banito Lab retweeted
Lowe Lab@LoweLabMSKCCApr 15
🚨 Just out from our lab in @cellbycellpress - a comprehensive review of cellular senescence, part of the special issue celebrating the Hallmarks of Cancer cell.com/cell/fulltext/S0092… 🚀
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Banito Lab retweeted
DKFZ@DKFZ25 Nov 2025
Dreaming of a career in cancer research? Join the Int'l PhD Program at DKFZ - Germany’s largest biomedical research center. Explore #cancerresearch including #cancerbiology, #bioinformatics, #epidemiology & #medicalphysics. The Winter Selection is open! 👉 t1p.de/amwgq
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#SCC2025HD is just around the corner. We are looking forward to welcoming the participants at our exciting 12th International Heidelberg Symposium on Stem Cells and Cancer.
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We’re looking for a lab manager for our growing lab: hhmi.wd1.myworkdayjobs.com/e… If you’re excited about aging, senescence ans CAR T cells and want to work in a friendly collaborative environment, come join us!!
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To all post-docs: The Genome Biology dept @embl has an Independent faculty position. Fantastic place to set up your lab, great package: core funding, fantastic PhD students, cutting edge core facilities & great colleagues embl.wd103.myworkdayjobs.com…
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HEALTH CARE PROVIDERS: Don’t dismiss it. Learn the red flags for potential sarcoma & help your patients get clear answers, quickly. Primary care is often the only window to intercept sarcoma early. Commit to “no non‑answers.” #SarcomaAwarenessMonth2025 #SarcomaSignsAndSymptoms
A graphic for Sarcoma Awareness Month 2025 featuring a row of red flags set against a gray sky. The caption reads: "Sarcoma Red Flags. Any lump 1-2 in (about 5cm) or more, even if painless, situated in the muscle or soft tissue. Any palpable bone lesion. Unexplained pain especially at night, if lasting more than a month. Learn the signs, insist on answers."

ALT A graphic for Sarcoma Awareness Month 2025 featuring a row of red flags set against a gray sky. The caption reads: "Sarcoma Red Flags. Any lump 1-2 in (about 5cm) or more, even if painless, situated in the muscle or soft tissue. Any palpable bone lesion. Unexplained pain especially at night, if lasting more than a month. Learn the signs, insist on answers."

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🚨 We're hiring a sequencing technician in #TRACERx! Join world-leading teams at @TheCrick & @uclcancer, working at the forefront of cancer research. Interested in cutting-edge genomic tech to understand cancer? Apply now! 👉 ucl.ac.uk/work-at-ucl/search… #Genomics #CancerResearch

UCL – University College London

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

ucl.ac.uk
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Spread the word: The European Center for Angioscience @UniHeidelberg continues to grow: We have openings for 2 additional Junior Group Leader positions. Get in touch with us if you are ready to start your own lab. See also corresponding ad in @Nature: nature.com/naturecareers/job…
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Excited to share our latest work out now in print @Nature! Lead by @almudena_Chaves and @ScottMillman_MD, we uncover how metabolic rewiring via OGDH controls tissue regeneration and stem cell fate in the intestine 🚀🚨 bit.ly/44oaOiW
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Thurs, June 26, 1:00–2:15 PM EST - “NCI Beyond Mammals: Exploring Cancer Models Webinar Series". Showcasing zebrafish as a discovery tool. Speakers: James Amatruda, David Langenau (me), and Kandice Tanner. Free but pre-registration is required. events.cancer.gov/dcb/beyond…
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🚨 New paper out in @NatureComms! We built a next-gen sarcoma modeling platform to help drive new therapies. 🧬 Big milestone for @SoftSarcoma and our global collaborators! 📄 Read it here: nature.com/articles/s41467-0…

Somatic gene delivery faithfully recapitulates a molecular spectrum of high-risk sarcomas

Nature Communications - Sarcomas are a group of mesenchymal malignancies which are molecularly heterogeneous. Here, the authors develop an in vivo muscle electroporation system for gene delivery to...

nature.com
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Banito Lab retweeted
dana_peer@dana_peer26 May 2025
The Single-cell Analytics Innovation Lab @MSKCancerCenter is looking for ML-oriented computational biologists. Join our team based in NYC to work on cutting-edge single-cell & spatial transcriptomics methods in collaboration with leading research labs. bit.ly/4lTEr2t
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We are offering an exciting project for aspiring clinical scientists! Cytoskeletal Dynamics in Circulating Tumour Cells from Breast Cancer Patients! Don't miss this opportunity to work at the interface between fundamental and clinical science😀 icr.ac.uk/study-and-careers/…
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Linking EF1 states to NK-mediated killing in Ewing sarcoma. Great work from Martha, Kim and the whole team: EWSR1::ETS-low cells promote metabolic reprogramming of the tryptophan-kynurenine-AHR axis, immunosuppression, and poor outcome in Ewing sarcoma biorxiv.org/content/10.1101/…

EWSR1::ETS-low cells promote metabolic reprogramming of the tryptophan-kynurenine-AHR axis,...

How activational changes of driver oncogenes can promote metabolic reprogramming and cancer progression is largely uncharted territory. To address this issue, we employed Ewing sarcoma (EwS) as a...

biorxiv.org
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Online Now: A specific form of cPRC1 containing CBX4 is co-opted to mediate oncogenic gene repression in diffuse midline glioma dlvr.it/TKvYxg

A specific form of cPRC1 containing CBX4 is co-opted to mediate oncogenic gene repression in...

Lagan, Gannon, et al. reveal that H3K27M-DMGs depend on a specific form of cPRC1 containing CBX4 and PCGF4. H3K27M alters H3K27me3 distribution, causing increased binding of CBX4-PCGF4-cPRC1 and...

cell.com
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Grateful to reflect on my engagement with #CCE shaped by fruitful collaborations, inspiring interactions and formative roles. If you're passionate about translational oncology, don’t miss the fantastic cross-disciplinary training opportunity at the CCE's Summer School! 🌴 Deadline is May 23! For more info, please check cancercoreeurope.eu/summersc…
Cancer Core Europe (CCE)@CancerCoreEU16 May 2025
Meet the people behind #CCE! 👩‍🔬 Today’s spotlight is on @priyachudasama5 from @NCT_HD & @DKFZ, part of CCE’s Rare Tumors Task Force. 💡 Discover more about her CCE journey in this interview👇 cancercoreeurope.eu/meet-pri…
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Successful FORTRESS meeting series is now resulting in first scientific publications, e.g. a guideline paper on the establishment of patient-derived 3D in vitro models of sarcomas. Congratulations to the very active working group members. Read De Cock L et al. in Neoplasia 2025
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New @Nature feature on team KOODAC and their pioneering work developing PROTACs to eliminate cancer-driving proteins Together with PROTECT & NexTGen, these 3 Cancer Grand Challenges teams aim to transform the paediatric therapy landscape. Read: go.nature.com/4dfEd1I
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My lab at @DKFZ in #Germany is looking for #bioinformatician to work on creative solutions for #multiomics #cancer prevention and #DNA #damage mechanisms. #Biologists becoming informatics-proficient - apply here. Deadline approaching. jobs.dkfz.de/en/jobs/167686/…
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Banito Lab retweeted
DKFZ@DKFZ25 Mar 2025
Do you want to do your #postdoc with the most prestigious #fellowship in Europe? Apply to DKFZ Marie Skłodowska Curie MasterClasses here: ➡️ t1p.de/uay9j Projects in #cancerresearch #genomics #bioinformatics #immunology #medicaltechnology #epidemiology @HorizonEU
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