@SlutzkyLab

Neuroprosthetics Lab - Brain machine interfaces & myoelectric interfaces for neurorehabilitation.

Joined March 2017
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Thrilled and grateful to share our paper out today in @Nature (rdcu.be/fbd7J). We used a brain machine interface (brain computer interface, #BCI) to causally test the origin of the high-gamma band of local field potentials #LFP. See explanation by @TH_Alec_Lei below
Tianhao Lei@TH_Alec_LeiApr 1
🎉 Excited to share our new paper in Nature: “Active Dissociation of Intracortical Spiking and High Gamma Activity.” 🧠 Huge thanks to my advisors first: @SlutzkyLab @joshuaiglaser Paper link: nature.com/articles/s41586-0… Here are some digests that walk you through the results 👇🏼
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We're hiring for a new project! If you are excited to work at the forefront of brain-computer interfaces, we would love to hear from you! #BCI sites.northwestern.edu/sneup… @joshuaiglaser
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Our paper is now in print in @Nature . If you're interested in local field potentials, especially #high-gamma activity, and/or #spikes, check it out! TL;DR: High gamma is not mainly filtered spikes, but mainly summed nearby PSPs. nature.com/articles/s41586-0…

Active dissociation of intracortical spiking and high gamma activity

Nature - A brain–machine interface is used in monkeys to investigate the biophysical underpinnings of cortical high gamma-band activity, a signal that is often studied in the context of many...

nature.com
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News coverage of our MINT RCT: wgntv.com/news/medical-watch… usnews.com/news/health-news/…

Video games show promise in stroke recovery

Video games can help stroke survivors improve their movement by using sensors to record muscle activity and translating it to cursor movements on the screen, providing up to 10 times more repetitio…

wgntv.com
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Excited that our RCT on myoelectric interface for #neurorehabilitation (MINT) conditioning is published in Neurorehab & Neural Repair! In 59 chronic stroke survivors, #MINT improved arm movement more than control and by a clinically sig amt. lnkd.in/gHryCmYT (1/n)

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(2/n) Participants kept improving 1 mo later. They performed 315 reps/day, >10x a typical therapy session. It's incredibly fulfilling to hear feedback from participants who experienced improved arm movement from the intervention.
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(3/n) Grateful for the many lab members and collaborators who made this work (esp Abed Khorasani, Cynthia Gorski, Prashanth Prakash, Nathan Hung, Vivek Paul, Goran Tomic, Richard Harvey, and Jinsook Roh) and our participants. Also thanks #NIH #NINDS for supporting this research.
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Also finally out: Research Briefing in Nature Magazine lnkd.in/g6XTwAkh describing our research article (@TH_Alec_Lei) a broader audience. Also describes the "story behind the paper". lnkd.in/gnAR8fde @NMNeurology

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Slutzky Lab@SlutzkyLabApr 1
Thrilled and grateful to share our paper out today in @Nature (rdcu.be/fbd7J). We used a brain machine interface (brain computer interface, #BCI) to causally test the origin of the high-gamma band of local field potentials #LFP. See explanation by @TH_Alec_Lei below
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Slutzky Lab retweeted
ChangLabUCSF@ChangLabUcsfJan 22
New work from our lab showing the human frontal lobe receives fast, low-level speech information in parallel with early speech areas! doi.org/10.1038/s41467-025-6…

Parallel encoding of speech in human frontal and temporal lobes

Nature Communications - Whether high-order frontal lobe areas receive raw speech input in parallel with early speech areas in the temporal lobe is unclear. Here, the authors show that frontal lobe...

nature.com
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Slutzky Lab@SlutzkyLabApr 1
Thrilled and grateful to share our paper out today in @Nature (rdcu.be/fbd7J). We used a brain machine interface (brain computer interface, #BCI) to causally test the origin of the high-gamma band of local field potentials #LFP. See explanation by @TH_Alec_Lei below
Tianhao Lei@TH_Alec_LeiApr 1
🎉 Excited to share our new paper in Nature: “Active Dissociation of Intracortical Spiking and High Gamma Activity.” 🧠 Huge thanks to my advisors first: @SlutzkyLab @joshuaiglaser Paper link: nature.com/articles/s41586-0… Here are some digests that walk you through the results 👇🏼
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NEWS: Massive budget cuts for US science proposed again by Trump administration "It's an extinction-level event for science". The US government is proposing massive cuts to almost every branch of science, from NASA to the National Institutes of Health. NSF would completely eliminate the social, economic and behavioral sciences directorate. This would decimate the world's leading scientific system. nature.com/articles/d41586-0…
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Update! Now out in print, with much more scientific details on representational plasticity and stability with neurofeedback that allows for long-term BCI control. cell.com/cell/fulltext/S0092… This study would not have been posssible if not for the enduring spirt of BCI participants

Sampling representational plasticity of simple imagined movements across days enables long-term...

Recordings from electrocorticography brain-computer interface (BCI) in tetraplegic participants find mesoscale representational stability and plasticity with neurofeedback that allows for long-term...

cell.com
Nikhilesh Natraj@NikhileshNatraj15 Aug 2023
!! New iBCI paper!! Using ECoG, we studied the interplay between representational stability and plasticity of a repertoire of simple mvmts. Despite drift, we could translate these principles for BCI control of a robotic arm, with high proficiency and stability for 7mos (1/n)
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Happy to announce that Prashanth Prakash's paper on decoding #speech intent from signals outside the frontal lobe is out today in JNE! iopscience.iop.org/article/1… (1/n)

Decoding speech intent from non-frontal cortical areas

Decoding speech intent from non-frontal cortical areas, Prakash, Prashanth Ravi, Lei, Tianhao, Flint, Robert D, Hsieh, Jason K, Fitzgerald, Zachary, Mugler, Emily, Templer, Jessica, Goldrick, Matthew...

iopscience.iop.org
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These signals were distributed widely throughout these areas.
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Thanks to Prashanth, @ohmykatkat, Robert Flint, Matthew Tate, @joshuarosenowMD, @emilymugler, @JasonHsiehMD, Matt Goldrick, @joshuaiglaser, Zach Fitzgerald and Jessica Templer. @NMNeurology @NeurosurgeryNM medicalxpress.com/news/2025-…... eurekalert.org/news-release...
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The NIH’s new imposed standard indirect cost rate threatens life-saving brain and behavior research that benefits millions of Americans. SfN, with other scientific organizations, urge reversal of this policy and implore Congress to protect critical research infrastructure. Read the full statement: bit.ly/4jVJnCL
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Slutzky Lab retweeted
Tony Zador@TonyZador8 Feb 2025
NIH funding supported : *** 412,041 jobs *** *** $92.89 billion in new economic activity*** *** $2.46 for every NIH $1 spent.*** We are a $100B industry. Let's act like it ! How about, at a bare minimum, we all just call our congressional reps??
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