@SleepResearch_

Highlights and news from the latest research on sleep

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Joined October 2012
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METABOLISM AND PHARMACOKINETICS OF VITAMIN D in PATIENTS with Cystic Fibrosis ift.tt/7R0pfPd

Metabolism and pharmacokinetics of vitamin D in patients with cystic fibrosis - PubMed

Patients with cystic fibrosis (CF) commonly have lower circulating concentrations of 25-hydroxyvitamin D (25(OH)D) than healthy populations. We comprehensively compared measures of vitamin D metabo...

pubmed.ncbi.nlm.nih.gov
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Acetazolamide for metabolic alkalosis complicating respiratory failure with chronic obstructive pulmonary disease or obesity hypoventilation syndrome: a systematic review ift.tt/x7tjaJg

Acetazolamide for metabolic alkalosis complicating respiratory failure with chronic obstructive...

CRD42021278757.

pubmed.ncbi.nlm.nih.gov
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Longitudinal evolution of cortical thickness signature reflecting Lewy body dementia in isolated REM sleep behavior disorder: a prospective cohort study ift.tt/FOT5sWc

Longitudinal evolution of cortical thickness signature reflecting Lewy body dementia in isolated...

Cortical thickness signature can effectively reflect the longitudinal evolution of Lewy body dementia in the iRBD population. Replication studies would further validate the utility of this imaging...

pubmed.ncbi.nlm.nih.gov
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Spatiotemporal characteristics of cortical activities of REM sleep behavior disorder revealed by explainable machine learning using 3D convolutional neural network ift.tt/tBYdf0O

Spatiotemporal characteristics of cortical activities of REM sleep behavior disorder revealed by...

Isolated rapid eye movement sleep behavior disorder (iRBD) is a sleep disorder characterized by dream enactment behavior without any neurological disease and is frequently accompanied by cognitive...

pubmed.ncbi.nlm.nih.gov
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Anti-LGI1 Encephalitis With Co-occurring IgLON5 Antibodies: Clinical Features and Human Leukocyte Antigen Haplotypes ift.tt/RJmQue7

Anti-LGI1 Encephalitis With Co-occurring IgLON5 Antibodies: Clinical Features and Human Leukocyte...

We present a case of anti-LGI1 encephalitis with concomitant IgLON5 antibodies. Co-occurring IgLON5 antibodies in anti-LGI1 encephalitis are exceptional, but may appear in genetically predisposed...

pubmed.ncbi.nlm.nih.gov
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Allnighter pseudokinase-mediated feedback links proteostasis and sleep in Drosophila ift.tt/EFUu6j1

Allnighter pseudokinase-mediated feedback links proteostasis and sleep in Drosophila - PubMed

In nervous systems, retrograde signals are key for organizing circuit activity and maintaining neuronal homeostasis. We identify the conserved Allnighter (Aln) pseudokinase as a cell non-autonomous...

pubmed.ncbi.nlm.nih.gov
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Orexin antagonism and substance-P: Effects and interactions on polycystic ovary syndrome in the wistar rats ift.tt/uTqAykZ
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Toward nanotechnology-enabled application of bilirubin in the treatment and diagnosis of various civilization diseases ift.tt/s9ZwPVJ

Toward nanotechnology-enabled application of bilirubin in the treatment and diagnosis of various...

Bilirubin, an open chain tetrapyrrole, has powerful antioxidant, anti-inflammatory, immuno-suppressive, metabolic-modulating and anti-proliferative activities. Bilirubin is a natural molecule that is...

pubmed.ncbi.nlm.nih.gov
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Combined healthy lifestyle in early pregnancy and risk of gestational diabetes mellitus: A prospective cohort study ift.tt/DdCUnox

Combined healthy lifestyle in early pregnancy and risk of gestational diabetes mellitus: A prospe...

A healthy lifestyle in early pregnancy was associated with a substantially lower GDM risk.

pubmed.ncbi.nlm.nih.gov
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Sleep Quality, Metabolic Function, Physical Activity, and Neurocognition Among Individuals with Resistant Hypertension ift.tt/cKsyxqH

Sleep Quality, Metabolic Function, Physical Activity, and Neurocognition Among Individuals with...

Better metabolic function and improved physical activity patterns levels play important roles linking sleep quality and executive function in RH.

pubmed.ncbi.nlm.nih.gov
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PERIOD phosphorylation leads to feedback inhibition of CK1 activity to control circadian period ift.tt/yFfiK7Q

PERIOD phosphorylation leads to feedback inhibition of CK1 activity to control circadian period -...

PERIOD (PER) and Casein Kinase 1δ regulate circadian rhythms through a phosphoswitch that controls PER stability and repressive activity in the molecular clock. CK1δ phosphorylation of the familial...

pubmed.ncbi.nlm.nih.gov
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Healthier Energy Balance Behaviors Most Important for Health-Related Quality of Life in Rural Cancer Survivors in Central Pennsylvania ift.tt/EJSvlhc

Healthier Energy Balance Behaviors Most Important for Health-Related Quality of Life in Rural...

Healthier energy balance behaviors were particularly relevant for HRQoL in rural cancer survivors. Multiple behavior change interventions to improve HRQoL in rural cancer survivors should focus on...

pubmed.ncbi.nlm.nih.gov
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Microglial NLRP3 inflammasome activation mediates diabetes-induced depression-like behavior via triggering neuroinflammation ift.tt/ClDo9SO

Microglial NLRP3 inflammasome activation mediates diabetes-induced depression-like behavior via...

The activation of NLRP3 inflammasome, probably mainly in hippocampal microglia, mediates the development of depression-like behaviors in STZ-induced diabetic mice. Targeting the microglial inflamma...

pubmed.ncbi.nlm.nih.gov
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A multicenter, double-blind, placebo-controlled, randomized, Phase 1b crossover trial comparing two doses of ulotaront with placebo in the treatment of narcolepsy-cataplexy ift.tt/kW07cfL

A multicenter, double-blind, placebo-controlled, randomized, Phase 1b crossover trial comparing two...

ClinicalTrials.gov identifier: NCT05015673.

pubmed.ncbi.nlm.nih.gov
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Association of Dapagliflozin vs Placebo With Individual Kansas City Cardiomyopathy Questionnaire Components in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction: A Secondary Analysis of the DELIVER Trial ift.tt/ke0MEWh

Association of Dapagliflozin vs Placebo With Individual Kansas City Cardiomyopathy Questionnaire...

ClinicalTrials.gov Identifier: NCT03619213.

pubmed.ncbi.nlm.nih.gov
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Interoceptive and metacognitive facets of fatigue in multiple sclerosis ift.tt/Nz4pVGy

Interoceptive and metacognitive facets of fatigue in multiple sclerosis - PubMed

Numerous disorders are characterised by fatigue as a highly disabling symptom. Fatigue plays a particularly important clinical role in multiple sclerosis (MS) where it exerts a profound impact on...

pubmed.ncbi.nlm.nih.gov
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Best Time of Day for Strength and Endurance Training to Improve Health and Performance? A Systematic Review with Meta-analysis ift.tt/MWqI7pX

Best Time of Day for Strength and Endurance Training to Improve Health and Performance? A Systema...

PROSPERO (CRD42021246468).

pubmed.ncbi.nlm.nih.gov
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Disease specific brain capillary angiopathy in schizophrenia, bipolar disorder, and Alzheimer's disease ift.tt/c7MO3vT

Disease specific brain capillary angiopathy in schizophrenia, bipolar disorder, and Alzheimer's...

Schizophrenia (SZ) and bipolar disorder (BD), which are both psychiatric disorders, share some common clinical evidence. We recently discovered that brain capillary angiopathy is another common...

pubmed.ncbi.nlm.nih.gov
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EEG spectral power during REM sleep in patients with frontal brain tumor ift.tt/a3pHiR7

EEG spectral power during REM sleep in patients with frontal brain tumor - PubMed

Brain tumors in the frontal lobe can modify the rhythmogenesis of REM sleep, possibly due to changes of brain plasticity as an effect of the pathology. In addition to this, through this study we were...

pubmed.ncbi.nlm.nih.gov
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No effects of different modalities of a single bout of exercise on sleep architecture and appetite in healthy overweight or obese young adults ift.tt/u2Rofe7

No effects of different modalities of a single bout of exercise on sleep architecture and appetite...

Acute aerobic exercise (intense or moderate) does not have beneficial or adverse effects on sleep quality and quantity in young adults with overweight/obesity. Subjective appetite may have a relati...

pubmed.ncbi.nlm.nih.gov
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