Principal Investigator at the Laboratory of Tumor Biology, @MasarykUni & Leader of the Laboratory Oncology Translational Research group, @FNUSA_ICRC
Brno, Czech Republic
Joined April 2021
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🔥 Hot off the @cddpress. Our paper on a novel #therapeutic #vulnerability to overcome multidrug resistance in #neuroblastoma has been published in Cell Death & Disease!
doi.org/10.1038/s41419-023-0…
@Kaja_Borankova et al.🧑🔬@BiologieUstav @FNUSA_ICRC @ChildrensPhila @syd_health
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That's it, I guess it's time to go 👉 bsky.app/profile/skodalab.bs…
Hope to see you there. Last one out turn off the lights... 😉
🥳 Excited to share our new paper on #pediatric #sarcomas! Restoring p53 tumor suppressor activity offers a promising approach to target aggressive, cancer stem-like cells in these childhood tumors: rdcu.be/d2ufo
@MasarykUni @FNUSA_ICRC @agentura_azvcr
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Finally, as all patient-derived models were wild-type p53, our findings suggest that restoring the p53 signaling could offer a promising strategy for treating refractory/metastatic p53-overexpressing pediatric sarcomas, regardless of their TP53 mutational status.
A tremendous effort by the first author Lucie Curylova! 👏 Huge thanks to my team @MasarykUni @FNUSA_ICRC and all collaborators @FNBrno @CEITEC_Brno. Funded by @agentura_azvcr, with institutional support from @NUVR_CZ @ZdravkoOnline 🙏
An interesting take on why conventional chemotherapy actually works or fails in cancer treatment 👇
Hugues de The and I want to remind you that nothing has cured more cancer patients than conventional chemotherapy!!! Think you understand how it selectively kills cancer cells so well? Take a look inside. @DanaFarber @DanaFarberNews
Jan Škoda retweeted
New study by @Kaja_Borankova @SkodaLab unexpectedly reveals that depleting the mitochondrial fission mediator DRP1 does not impair pediatric sarcoma chemoresistance and growth, ruling out DRP1 as a therapeutic target in these tumors. @MasarykUni @FNUSA_ICRC
life-science-alliance.org/co…
Stressful life events during pregnancy and certain congenital pathologies are independently associated with NB risk doi.org/10.1002/pbc.31402 👀 Interesting study that nicely aligns with the identified serotonin-mediated feedback loop in development & NB 👇 @adameykolab @PKameneva
Did you ever wonder why pregnant woman should be careful about being #stressed? Our new paper in Nature Communications describes a mother-to-child link, which influences the development of #adrenalglands though the molecule for happiness #serotonin.
nature.com/articles/s41467-0…
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Happy to see the 2nd paper from @Kaja_Borankova's PhD finally out in @LSAjournal 🤩👇 A yet-to-be-characterized DRP1-independent mechanism compensates for mitochondrial fission & cell survival in drug-resistant pediatric sarcomas. @MasarykUni
@FNUSA_ICRC
doi.org/10.26508/lsa.2024028…
📢Check out @SkodaLab's latest preprint: Depletion of chemotherapy-responsive #mitochondrial fission mediator #DRP1 unexpectedly does NOT mitigate #sarcoma 💊chemotherapy resistance.
@Kaja_Borankova et al.🧑🔬🔬@BiologieUstav
@FNUSA_ICRC @NUVR_CZ
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biorxiv.org/content/10.1101/…
🚨 Our study reveals that DRP1-targeted strategies for sarcoma therapy are likely to fail 💊 #GAČR @NUVR_CZ. This was our first time publishing with @LSAjournal, and I can only commend the quality of the editorial process-just like with EMBO J. 👍 Highly recommended! 😉
Jan Škoda retweeted
Přední 🇨🇿 dětský onkolog Jaroslav Štěrba, přednosta Kliniky dětské onkologie @FNBrno, v rozhovoru pro @novinkycz o tom, jak se liší rakovina u dětí a dospělých, proč se musí na léčbu často pořádat sbírky a je-li dětská onkologie smutný obor
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novinky.cz/clanek/zdravi-det…
🎉 Celebrating in style 🥳 Delighted to share that we've received a grant from GAČR! We will dissect mitochondrial stress signaling to elucidate its role in regulating the “undruggable” MYC proteins for therapies of MYC-driven tumors. 🚨 We're hiring a postdoc! Full posting soon.
🎉 Another paper accepted! What are the chances?!? Two revisions submitted in two days, two 'accept' decisions received in two days 🥹 Proud of my team and papers' first authors, Lucka Curylová & @Kaja_Borankova. Tweetorials coming soon! 😉 @MUNI_Science @FNUSA_ICRC