@SingletonNeuro

Opinions are my own & do not rep NIA/NIH/HHS

Joined March 2018
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  • Following160
  • Followers923
33Media
Great opportunity!!! @interneurona could you share it between your #LATAM colleagues???
Aligning Science Across Parkinson’s@ASAP_Research8 Aug 2023
📢 Reminder! The application window to apply for trainee funding through GP2's Underrepresented Populations PhD Program closes 8/31. If you identify as a supervisor from an underrepresented group, apply today pulse.ly/bzgbq5dpcd

GP2 Underrepresented Populations PHD Program 2023

We are inviting supervisors who identify as belonging to an underrepresented group in Parkinson’s disease (PD) research to apply for funding for a trainee who is also from an underrepresented group...

gp2.org
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Kimberley has done an amazing job standing up high throughput long read sequencing at CARD….
Oxford Nanopore
@nanopore19 May 2023
Today we heard from Kimberley on utilising long nanopore reads to sequence ~4,000 human brain clinical research samples, to further understand Alzheimer’s disease and related dementias #nanoporeconf
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love this collaboration!
Jennifer Yokoyama@YokoyamaLabUCSF18 May 2023
Our own @C_WSolsberg @halsty and friends from NIH CARD 🧬 identify novel AD loci by leveraging diversity across populations @UCSFmac
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Been a great day for publications from the team. @mkoretsky1 and the team great job on showing genetic overlap and in some instances a depletion of genetic risk across and within neurodegenerative diseases. – at Nashville, TN
The Science of Parkinson's@ScienceofPD18 May 2023
Genetic risk factor clustering within and across neurodegenerative conditions (such as #Parkinsons, #Alzheimers, #ALS) - from @HamptonLLeonard & colleagues; "Neurodegenerative diseases have more overlapping genetic etiology than previously expected" academic.oup.com/brain/advan…
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Dramatic improvement for @nanopore DRS using kits RNA004 vs RNA002 @NUBioE1 a) Human poly-A RNA alignment identity: 2019 (RNA002, 86%), 2022 (RNA002, 89.8%), 2023 (RNA004, 95.6%) b) Human MT poly-A RNA read alignments (2019 vs 2023). Colored lines = base mismatches @AkesonUCSC
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Pssst, next GP2 release in ~2 weeks 🤐. Release 5 for Cinco de Mayo (well a few days after). – at Bethesda, MD
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41 novel targets, network insights and potential tox inferences ... #opensource #openscience ... app here nih-card-ndd-smr-home-syboky…. Awesome work from Chelsea X. A. (sensibly twitter averse) to leverage public resource to do this (thx @OpenTargets and other for the APIs)!

Streamlit

Code for streamlit app to accompany manuscript

nih-card-ndd-smr-home-syboky.streamlit.app
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New preprint from the team at CARD, nominating novel drug targets for neurodegenerative disease using multi-omic and genetic data. Hoping this is a starting point for community target discovery specifically focused on ADRD. medrxiv.org/content/10.1101/…
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Funding opportunity! GP2 is co-funding two places for @movedisorder Aspen Course. If you are an early career Movement Disorders Fellow who identifies as belonging to an underrepresented group in #PD research, we encourage you to apply. Deadline is 5/1: pulse.ly/4uqz6ymutl

GP2 Training Opportunity: MDS Aspen Course 2023

The “Aspen Course” provides a robust scientific content and interaction with the leaders and innovators of the movement disorders field. This makes the Aspen Course an unique opportunity for those…

gp2.org
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Great presentation of @mario_cornejo_o in #IIIcongressobrasileironeurogenetica @LARGE_PD @ASAP_Research @arturschuh @nachogenePD – at Sao Paulo, Brazil
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I wrote a blog post for International Women's Day, featuring women in #datascience and #neuroscience at @NIHAging's Center for #Alzheimers and related dementias! card.nih.gov/news-events/car… #scicomm #InternationalWomensDay
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🎉In case you missed it📢 BLAAC-PD is expanding to six sites, allowing the initiative to continue to grow its partnerships with traditionally underrepresented populations and helping to unlock the genetic architecture of #ParkinsonsDisease. michaeljfox.org/publication/…

Parkinson’s Genetics Study Expands in Black and African American Communities

The BLAAC PD study expands to six research sites to better understand the genetics of Parkinson’s disease in Black and African American populations.

michaeljfox.org
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If you are a doctor or scientist based in Africa, Asia or Latin America interested in getting a master's in clinical neurology or data science via distance learning @ucl or @UMBC, apply for GP2 support! Learn more: gp2.org/opportunities/?utm_s…

Career Opportunities

Discover career opportunities across multiple disciplines at GP2, specializing in accelerating Parkinson’s research and innovation.

gp2.org
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V Excited about this....Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD biorxiv.org/content/10.1101/…

Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD

Functional loss of TDP-43, an RNA-binding protein genetically and pathologically linked to ALS and FTD, leads to inclusion of cryptic exons in hundreds of transcripts during disease. Cryptic exons...

biorxiv.org
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📢 Apply to get trained in data science while working with a ton of talented and motivated scientists on Alzheimer’s and related dementias research at #CARD ! 📢 🤩
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A nice thread here:
Paul Thompson
@PTenigma30 Nov 2022
BREAKING NEWS: New #Alzheimer drug #Lecanemab slows cognitive decline (18-month change in CDR-SB) by 27%, drastically lowers brain amyloid load by 59 centiloids to 23 (below PET amyloid positivity)! NEJM paper: nejm.org/doi/full/10.1056/NE… prnewswire.com/news-releases… #CTAD
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It’s quafftide somewhere. Here in fact.
Susie Dent
@susie_dent18 Nov 2022
Word of the day is ‘quafftide’(16th century): a one-word announcement that it’s time for a drink.
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gp2.org/the-components-of-gp… @ASAP_Research says GP2 release 3 is now official. Shout outs to the team for sharing > 14K samples! Nice work in particular from @HamptonLLeonard @KristinSLevine @mbmakarious #DanV and #MatK on the blog post and README. READMEs, always important 🧐.

The Components of GP2’s Third Data Release

In October 2022, GP2 announced the third data release on the Terra platform in collaboration with AMP® PD. This release is packed full of new data and resources and includes almost twice as many…

gp2.org
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a fantastic resource....really excited to support this work through CARD at the NIH IRP. Next comes the exciting part...
M W@Michael_E_Ward_8 Nov 2022
New batch of engineered iPSC lines from JAX/iNDI, including much-requested APOE variants! Isogenic sets of APOE2, 3, 4, and Christchurch variants, plus revertant controls, all deeply QC'd and available with a clickable online MTA. jax.org/jax-mice-and-service…
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Anyone dug around in their GP2 tier2 buckets lately? If so, how's new data in release 3 (its live already in your workspace 😈). R3 is official very soon (couple weeks), keep your eyes on the GP2 blog. Epic teamwork from too many (some on this call)! #OpenScience
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