The number of female #BreastCancer survivors is projected to reach 5.3 million by 2035—an increase of one million women from 2025, marking the largest projected growth among the top 10 most prevalent cancers. More stats at: acsjournals.onlinelibrary.wi… @OncoAlert @docnikitawagle

Today our lab is excited to share a new study in Cell: “Non-invasive control of gene editing in vivo by photoswitchable Cas12f and focused ultrasound.” We engineered a compact CRISPR system that can be activated at specific locations in the body using focused ultrasound (🧵)

Everyone ages differently - something we have long suspected is now supported by longitudinal data from 335 female twins collected over 8 years. science.org/doi/10.1126/scie…

Green flower coloration through AT-hook protein-mediated histone H3K27ac deacetylation in chrysanthemum (Hongfeng Huang , Jiaqi Wen , Ying Zheng , et al) doi.org/10.1093/plcell/koag2… @ASPB #PlantSci

IN BRIEF: Should they stay or should they go? Regulating microRNA turnover in plants (Soledad Traubenik) doi.org/10.1093/plcell/koag0… @traubenik @ASPB #PlantSci

New online! HERC4-mediated ubiquitination licenses RIPK1 to initiate TNF-induced cell death dlvr.it/TVggtH

🚨 Imaging the hallmarks of cancer @NatureRevCancer nature.com/articles/s41568-0… 🔍 PET, MRI & optical imaging → beyond anatomy 🧬 Visualizing metabolism, angiogenesis & immune evasion 🤖 Radiomics + AI → mapping tumor heterogeneity ⚠️ Promising biomarkers, but clinical validation remains essential Cancer has its hallmarks. Now we need to make them visible. 👁️ @OncoAlert @OncoReporte @myESMO @_SEOM @GrupoMelanoma @gecp_org @GrupoTTD

Aging does not appear to follow the same molecular script for everyone, according to an 8-year study of more than 300 women. The findings in Science reveal that individual molecular trajectories of aging can diverge substantially from population-wide patterns and are shaped not only by genetics but also by factors such as circadian rhythm, seasonality, and environmental exposures. Learn more: scim.ag/4ikMUfG

Bidirectional photoriboswitch for translational regulation in mammalian cells sciencedirect.com/science/ar…

The Hidden Bottleneck of CRISPR/Cas12a Deletions! 🧬⚡ Traver Hart’s Lab at MD Anderson Cancer Center Evaluates 77,000 Dual-gRNA Combinations on bioRxiv (2026)! Single-target Cas12a cuts efficiently, but dual-flank cutting fails to drive locus deletion in mammalian screens! 🎯📦 Key Technological Breakthroughs: 🔬 77k Dual-gRNA Screen: Tested ~77,000 dual-gRNA pairs targeting 54 essential exons across 18 genes in A375 melanoma cells expressing enAsCas12a. ⚠️ Severe Efficiency Gap: Dual-intron flanking cuts produced minimal depletion (Cohen’s d = 0.08 vs. single-intron controls), behaving like single-site cuts rather than full exon knockouts. ❌ Design Predictors Fail: CRISPick scores (R^2 = 0.02-0.04), gRNA orientation (Cohen’s d = 0.01), GC content, and cleavage distance (104 to 2132 bp) failed to predict locus excision. 💡 Asynchronous Cleavage Hypothesis: Proposes that asynchronous DSB timing leads to independent local repair rather than coordinated fragment excision. A critical reality check for non-coding and multi-target CRISPR screen design! 🚀🌟 doi.org/10.64898/2026.09.21.… #CRISPR #Cas12a #bioRxiv2026 #MDAnderson #GeneEditing #FunctionalGenomics

Chemical Programming Reimagines CRISPR RNP Delivery! ⚡ Ross C. Wilson’s Team at UC Berkeley Introduces PERCEPT on bioRxiv (2026)! Directly modifying CRISPR RNPs with reversible chemical coats unlocks targeted in vivo editing across brain, retina, muscle, and lung tissues! 🎯📦 Key Technological Breakthroughs: 🧪 Reversible Covalent Modification: A self-immolative, reduction-sensitive linker attaches PEG (tissue diffusion), escape peptides (endosomal release), and ligands (cell targeting), shedding in the cytoplasm to release native RNPs. 🧠 CNS Striatum & Thalamus Editing: P55 + TET1 + PEG formulation achieves 56% striatal volume coverage, editing 78% of NeuN⁺ neurons and reducing mutant HTT aggregates and neuroinflammation in R6/2 Huntington’s mice. 👁️ Retina & 🦾 Skeletal Muscle: P55 + TET1 edits 53% of Sox9⁺ Müller glia; S315 + PEG boosts muscle fiber editing efficiency by 10-fold. 🫁 Sustained Airway Editing: P55 + PEG aerosol delivery edits airway epithelium and p63⁺ basal stem cells, maintaining edit signals for 12 weeks. A modular, non-viral delivery chassis for non-liver gene editing therapeutics! 🚀🌟 doi.org/10.64898/2026.09.14.… #CRISPR #GeneEditing #UCBerkeley #bioRxiv2026 #PERCEPT #RNPDelivery #BaseEditing

Now online! Single-cell visual proteomics of a minimal bacterium reveals structural coordination of gene expression machineries dlvr.it/TVgMq5

The curious case of the placental genome In this Review, Zoé Ducarne, @AgChaigne and @myanhtruong01 highlight the placenta, the only mammalian organ that harbors a cancer-like genome while remaining functional and healthy. doi.org/10.1242/dev.205800

Hearts from young donors age rapidly in the bodies of older recipients, and older hearts are rejuvenated inside young people go.nature.com/4rzzsHf