@SiekmannLab
 Philadelphia
med.upenn.edu/siekmannlab/
Joined July 2021
  • Tweets39
  • Following97
  • Followers550
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Happy to share Zeenat's paper in Angiogenesis on differences between arterial and venous cell sizes and the specific role of endoglin signaling in veins! Great job! link.springer.com/10.1007/s1…

Alk1/Endoglin signaling restricts vein cell size increases in response to hemodynamic cues

Angiogenesis - Hemodynamic cues are thought to control blood vessel hierarchy through a shear stress set point, where flow increases lead to blood vessel diameter expansion, while decreases in...

link.springer.com
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Arndt will be speaking at 18th International Zebrafish Conference. Please check out my talk if you're attending the event! #IZFC2024 - via #Whova event app
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Congratulations @Zeenat_JL for successfully defending her PhD @CAMBUpenn! Well deserved!!
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Happy to share our latest results on arteriovenous malformations! Congratulations to PhD student Zeenat Diwan @Zeenat_JL for her great work! Alk1/Endoglin dependent increases in vein endothelial cell sizes precipitate arteriovenous malformations biorxiv.org/content/10.1101/…

Alk1/Endoglin dependent increases in vein endothelial cell sizes precipitate arteriovenous malfor...

Aberrations in blood vessel diameters can disrupt the hierarchical patterning of the vasculature and cause congenital vascular anomalies, such as arteriovenous malformations (AVMs). Despite the...

biorxiv.org
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Happy to share out latest review article on Vascular Mural Cells published in @Dev_journal ! journals.biologists.com/dev/…

Biology of vascular mural cells

Summary: This Review examines the signalling pathways controlling vascular mural cell biology during development and regeneration and analyses their role in proper vascular function in health and...

journals.biologists.com
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Enjoying a great meeting in Barcelona! #evbo
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Very happy to share that Arndt just got tenure at UPenn! Thanks a lot to all previous and current members of the lab for their great work and enthusiasm to make this happen. Enjoying hot pot with the lab to celebrate!
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This #FluorescenceFriday we highlight the forming vasculature in a zebrafish fin. Research from @ElvinLeonard3, Sana Hasan & @SiekmannLab reveals the existence of distinct morphogenetic processes that generate the mature fin vasculature. 📖@Dev_journal: journals.biologists.com/dev/…
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Happy to announce that our latest paper on fin blood vessel development is online now: journals.biologists.com/dev/… Congratulations to @ElvinLeonard3 and Sana S. Hasan for the amazing work!
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Siekmann Lab retweeted
NAVBO@vascularbiology13 Dec 2022
Join us THIS THURSDAY Dec 15th at 1PM EST for InFocus Session: Vascular Malformations. Trainee speakers were chosen from Abstracts submitted to #IVBM2022. These sessions are NOT recorded so don't miss out!! Register now- These sessions are free to ALL! conta.cc/3uQUNzf
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Siekmann lab reunion @ivbm2022. Having fun with @Zeenat_JL, @ElvinLeonard3, Martin Lange and Sana Hasan.
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Temporally and regionally distinct morphogenetic processes govern zebrafish tail fin blood vessel network expansion biorxiv.org/content/10.1101/…

Temporally and regionally distinct morphogenetic processes govern zebrafish tail fin blood vessel...

Blood vessels form elaborate networks depending on tissue-specific signalling pathways and anatomical structures to guide their growth. However, it is not clear which morphogenetic principles...

biorxiv.org
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Happy to share our results on zebrafish tail fin blood vessel expansion by @ElvinLeonard3 and Sana Hasan! Fascinating to compare to work by @ScottPaulissen from the Weinstein lab, @Rudra_nayan from the @Yaniv_lab and Rosalind Bump from @jraslab! Similar, but different! So cool!
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Wow! After a long covid slumber, third paper out within 2 weeks! Congratulations to the first author Martin Lange and our collaborators from the @RuiBenedito_ lab! Zebrafish mutants in vegfab can affect endothelial cell proliferation ... sciencedirect.com/science/ar…
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Looks pretty awesome! Congratulations on the nice achievement.
@luschnig.bsky.social@StefanLuschnig28 Mar 2022
Acute manipulation and real-time visualization of membrane trafficking and exocytosis in #Drosophila. We brought #RUSH, conceived by Franck Perez @Team_FranckP in cultured cells, to the fly, illuminating secretion dynamics in live animals @biorxiv_cellbio doi.org/10.1101/2022.03.25.4…
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New findings often come unexpectedly! A large extracellular protein produced by non vascular cells cooperates with blood flow to stabilize new vessel connections! Delighted to share and discuss this with you. Great collaboration with Stefan Schulte-Merker!
Development@Dev_journal24 Mar 2022
Svep1 connects anastomosis and blood flow A Research Highlight showcasing new work from Baptiste Coxam @BCoxam, Holger Gerhardt @holger_gerhardt and colleagues journals.biologists.com/dev/…
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Happy to share out latest paper on vascular mural cells in developing and regenerating zebrafish fin arteries out in @Dev_journal. Congratulations to the first author @ElvinLeonard3 for the great work. journals.biologists.com/dev/…
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Excited to share our latest research on shear stress regulated endothelial enhancers in @SciReports. Great collaboration with the Schnittler laboratory, @vaquerizas_lab and @AranyLab! rdcu.be/cJtta
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Great to see #zebrafish taking the center stage! Awesome collaboration! Thanks! @BugajLab
Lukasz Bugaj@BugajLab31 Jan 2022
and a huge thanks to @SiekmannLab for getting us started with these beautiful creatures.
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Here it is! PPIL4, a new gene associated with Intracranial Aneurysms in humans, a new Wnt-mechanism of brain arteries formation, a step forward to understand this disease! So proud of everyone that worked on this project! nature.com/articles/s41591-0…

PPIL4 is essential for brain angiogenesis and implicated in intracranial aneurysms in humans

Nature Medicine - Genomic analyses in individuals with index and familial intracranial aneurysms and experiments in vertebrate models identify pathogenic variants in the PPIL4 gene implicated in...

nature.com
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