Systems biology @bsmsMedSchool | UKRI Future Leaders Fellow | co-director @sussex_cancer | Speciality Chief Editor: Systems Immunology @FrontImmunol
Brighton
Joined May 2008
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We’re excited to announce that we’re looking for a postdoctoral research to join our team!
This is an opportunity to lead an exciting project aiming to push the boundaries of personalised medicine through integrating data, simulation and lab experiments.
mitchell.science/talk/we-are…
Simon Mitchell retweeted
We're excited to annoucen that @SxCancerFund SCRC research awards are open for applications, with funding up to £10k or £30k. Priority areas include data science, population datasets, prevention, early diagnosis, and mental health.
sussexcancer.org/funding
Simon Mitchell retweeted
✨ How is BSMS lighting the way in cancer research?
Dr Simon Mitchell (@SiFTW) & Prof Melanie Flint share the mission at the Sussex Cancer Research Centre: pioneering interdisciplinary research that will improve cancer treatments & outcomes. @Sussex_Cancer
youtube.com/watch?v=w8YlZPuI…
Excited to have been promoted to Professor in Cancer Systems Biology at @BSMSMedSchool, @SussexUni, @uniofbrighton
Reflecting triggers imposter syndrome tbh. But I owe it to a series of advisors/supervisors/mentors who believed in me and my approaches.
Particularly, Pedro Mendes, @ahoffmann2716, and @ChrisPepper64, who supported me in so many ways from PhD, to postdoc, and PI respectively.
I especially owe this promotion to the incredible and inspiring scientists that I’m fortunate enough to call my team, collaborators, and co-directors of @Sussex_Cancer
I’m most excited to use my position to repay some of the incredible support I’ve had by supporting others.
🍻
Simon Mitchell retweeted
Very grateful to have been awarded our 1st @bloodcancer_uk @BloodCancer_Res research grant over the summer for our work targeting aberrant Wnt/β-catenin signalling in acute myeloid leukaemia (AML).
New project begins Oct 1st developing new ways to target oncogenic β-catenin 👊
I’ll forever be grateful to @LeukUK and their supporters for being the first to support our work using simulations to tailor treatments in blood cancer.
Our lab @BSMSMedSchool and @Sussex_Cancer exists because of you.
It was fun to share some of what I’ve learned with ECRs today.
“There’s no way I’d be sitting in front of you now if I didn’t receive the John Goldman Fellowship.”
Some established researchers share their experiences and advice for those starting out in the field. 🔬🧡
ALT Four people are sitting in a line behind a table, forming a panel. A presentation screen behind them reads, ‘Early Career Researcher support’.
Simon Mitchell retweeted
“There’s no way I’d be sitting in front of you now if I didn’t receive the John Goldman Fellowship.”
Some established researchers share their experiences and advice for those starting out in the field. 🔬🧡
ALT Four people are sitting in a line behind a table, forming a panel. A presentation screen behind them reads, ‘Early Career Researcher support’.
Simon Mitchell retweeted
Have you or a loved one experienced cancer?
We’re looking for volunteers with lived experience of cancer to join our Experts by Experience panel.
Your voice can help shape the future of cancer research in Sussex.
Apply here: sussexcancer.org/experts
Apply by 30/09/2025
Simon Mitchell retweeted
Congrats to our John Goldman Fellow, @SiFTW and team! Their research shows how lymphoma cells evade treatment by switching between “survival” pathways. The team have discovered how to predict and overcome this resistance, which could lead to more tailored treatments. 👏
New paper led by Aimilia Vareli out now.
nature.com/articles/s41419-0…
The lymphoma microenvironment stops BH3-mimetics from working.
In vitro/vivo/silico, we find that inhibition of NFκB makes BH3-mimetics great again.
1/🧵
@Sussex_BCR @Sussex_Cancer @LeukUK @BSMSMedSchool #UKRIFLF
New paper led by Aimilia Vareli out now.
nature.com/articles/s41419-0…
The lymphoma microenvironment stops BH3-mimetics from working.
In vitro/vivo/silico, we find that inhibition of NFκB makes BH3-mimetics great again.
1/🧵
@Sussex_BCR @Sussex_Cancer @LeukUK @BSMSMedSchool #UKRIFLF
Finally, we find that despite all this complexity there is one strategy that always works to overcome the TME.
Inhibition of the key regulator of non-canonical NF-kB (NIK) totally neutralises the drug resistance caused by the TME in DLBCL🎉
5/🧵
I can’t recommend this job enough.
@oberoi_jasmeen is leading a really exciting research programme and you couldn’t want a better mentor.
Nearing the end/completed your PhD? Interested in leukaemia research? Want to join a new and exciting PI as they establish their group at @SussexLifeSci
Then this 3y post doc post with newly minted MRC CDA Fellow & @BloodCancer_Res funded Dr @oberoi_jasmeen could be for you 👇
Simon Mitchell retweeted
Last month, final year PhD student Aimilia Vareli from @SiFTW lab in @BSMSMedSchool presented her research at the annual @EHA_Hematology congress 2025 in Milan, and has been awarded an EHA Research Mobility Grant to progress her work with collaborators at @Harvard university 👏
New paper led by @ejayawant 🎉
We review:
- how computational biology is helping us understand lymphoma,
- how machine learning and cell simulations make sense of vast amounts of data,
- how models can personalise treatments to each person with lymphoma.
portlandpress.com/biochemsoc…
