@Shuo_Han_
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Molecular labeling for biology and medicine. PI at Shanghai Institute of Biochemistry and Cell Biology.
Joined November 2020
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Excited to share the first paper from my lab in @Nature ! We repurposed the widely used research tool, proximity labeling, to demonstrate its therapeutic potential in antigen amplification for immunotherapy using mouse tumor models and patient samples.
nature.com/articles/s41586-0…
Shuo Han retweeted
A nontoxic proximity labeling method generating H2O2 in situ from D-amino acids enables protein and RNA proximity labeling and mapping RNA structural changes in vitro and in vivo
nature.com/articles/s41589-0…
The devil wears PRADA and now so can cells! Our latest technology-PRADA (Peroxidase Reaction Activated by D-amino Acids) enables in vivo proximity proteomics, transcriptomics, RNA structuromics, and polymer assembly in diverse model organisms. nature.com/articles/s41589-0…
I learned so much from our wonderful collaborators @ywan_wan and @JiefuBiol. And grateful for all the hardwork by cofirst authors Jiapeng from my lab and Jian from Yue' group. Hope it will become a useful tool!
I learned so much from our wonderful collaborators @ywan_wan and @JiefuBiol. And grateful for all the hardwork by cofirst authors Jiapeng from my lab and Jian from Yue' group. Hope it will become a useful tool!
Existing RNA LLMs often have short context lengths for mRNAs, limiting full-length modeling applications. Here we present RIBOSPAN, a 1.61B foundation model with context lengths up to 10,240nt. Arxiv link: arxiv.org/abs/2608.22849. Github: github.com/GAIR-NLP/RIBOSPAN….
Building on this foundation model, we are now training with various data generated in our lab to build predictive and generative RNA tools for cancer immumotherapy applications. Please stay tuned 😀
Shuo Han retweeted
Out today!
CD300ld, upregulated in pathologically activated neutrophils, mediates contact-dependent suppression of cytotoxic CD8+ T cells by binding to phosphatidylserine, inhibiting antitumor immune responses and revealing a targetable checkpoint pathway
nature.com/articles/s43018-0…
cen.acs.org/people/profiles/… Really honored and thrilled to be selected for 2026 C&EN Talented 12 of the American Chemical Society. Look forward to the award symposium at the ACS fall meeting in Chicago! We excited to push proximity labeling chemistry further into therapeutic space!
Shuo Han retweeted
Video introduction to our new “Conformational Biasing” method for computational design of mutations that bias proteins towards desired conformational states
CB part starts at 14:55
youtube.com/watch?v=4v_ZqWoA…
Thanks to @PeterECavanagh and Andrew Xue – amazing graduate students who co-led this work
Shuo Han retweeted
Can we design mutations that predictably bias proteins towards desired conformational states?
Today in @ScienceMagazine, we introduce Conformational Biasing (CB), a simple and scalable computational method that uses contrastive scoring by inverse folding models to identify conformation-biasing mutations.
science.org/doi/10.1126/scie…
Shuo Han retweeted
Huge congrats to @Raiseemhigh and all collaborators @BroadProteomics @aliceyting @Shuo_Han_ @StanfordBrain @HHMINEWS @HHMIJanelia!
(Sneak in an ad: my lab at Janelia is seeking a highly motivated postdoc interested in kidney physiology. Pls share!)
cell.com/cell/fulltext/S0092…
Shuo Han retweeted
Today, I would like to honor the memory of Roger Y. Tsien, who died on August 24, 2016. His legacy lives with all who use his technologies, including calcium sensors, fluorescent proteins, the acetoxymethyl (AM) ester, & many more! #FluorescenceFriday
nature.com/articles/nmeth.40…
Shuo Han retweeted
The FASEB BioAdvances journal team would like to welcome new Editorial Board member @Shuo_Han_ of the Shanghai Institute of Biochemistry and Cell Biology! Welcome aboard! bit.ly/42Z8OK2 #FASEBBioAdvances
Shuo Han retweeted
Our work on ENTER is finally out @CellCellPress! Like📱that can 📷📞🎧, ENTER is a modular viral platform that unifies multiple applications:
⭐️Decode Ligand-Receptor interaction
⭐️Receptor-specific cargo delivery
⭐️Link receptor specificity with cell state at single cell
Shuo Han retweeted
Woohoo! Big congrats to @JiaqiShen1, @LequnGeng and Xingyu Li for all their collaborative work leading to a brand new publication in @naturemethods! Our group teamed up with Prof Peng Li’s Lab 👏🏻!!! (@UMLifeSciences & @UMichDentistry) nature.com/articles/s41592-0…
Shuo Han retweeted
Prostate cancer occurs more frequently at the peripheral zone (PZ) than in transition zone (TZ) prostate, but the underlying mechanism is unclear. Study by Dr. Deyong Jia in my lab at @NatureComms provides one explanation for this clinical observation. doi.org/10.1038/s41467-022-3…
Thanks a ton to @DamonRunyon for organizing our amazing retreat! Fantastic talks from all fellows and really inspirational career advice from former alum @ValerieJHorsley. Also visited many friends and mentors at MIT Chem first time since I left 2016. See you next time Boston!
