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Joined June 2020
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#ODX 1/8
Yes, itâs more research đ
The Gov have ordered Automated LFT Cassette Assembly Equipment from Huxley Bertram Engineering based in Cambridge. Itâs worth noting that Omega also have a base in Cambridgeshire and Mologic in Bedford (45 mins away).
bidstats.uk/tenders/?q=huxleâŚ
Context on the DLT within C2 đđ˝
ââThis was felt not to be clearly anthracycline related cardiotoxicityââ
As mentioned, there were no DLTs at the *higher* doses of 160mg/m² and 200mg/m² within C3 and C4 respectively.
#AVCT
Systemic levels of dox and plasma exposure reduced up to 90% when compared to standard dox.
Sadly, 1 patient of 19 had a DLT. This was within C2 at 120mg/m².
However, there were no DLTs at the *higher* doses of 160mg/m² and 200mg/m² within C3 and C4 respectively.
#AVCT
3 tumour to plasma ratios greater than 100:1.
ââThese concentrations are within the therapeutic window where we might expect clinical benefit or efficacyââ
ââPreferential concentration of dox released from AVA6K in the tumour relative to the peripheryââ
#AVCT
ââThese concentrations are within the therapeutic window where we might expect clinical benefit or efficacyââ
ââA significant concentration of dox in those tumour biopsiesââ
ââPreferential concentration of dox released from AVA6K in the tumour relative to the peripheryââ
1
5
1,537
ââ*Huge* potential for next gen doxââ
ââThere is *considerable* scope for improvement on the profile of conventional & liposomal doxââ
ââAVA6K can safely deliver larger doses of doxorubicin to tumour whilst sparing healthy tissues & organsââ
Itâs all there, in writing.
#AVCT
20
1,596
#AVCT
ââThese concentrations are within the therapeutic window where we might expect clinical benefit or efficacyââ
ââA significant concentration of dox in those tumour biopsiesââ
ââPreferential concentration of dox released from AVA6K in the tumour relative to the peripheryââ
And there you have it; 3 tumour to plasma ratios greater than 100:1.
@MylesMcNulty đ¤đ˝
#AVCT đ¤Ż
And there you have it; 3 tumour to plasma ratios greater than 100:1.
@MylesMcNulty đ¤đ˝
#AVCT đ¤Ż
A link to the video recording of yesterday's Therapeutics Science Day is now available on our website, along with all the presentations given. avacta.com/investors/documen⌠#AVCT
#AVCT - WOW! đ¤Ż
18:1 in mice⌠100:1 in humansâźď¸
@MylesMcNulty đđť
#AVCT
Key word in todayâs RNS - âmaterialâ.
Weâve already been in receipt of the material info on 17th Jan.
We will however receive new info, detailed info; of which we as SHs may classify as *material*
đ
@Avacta voxmarkets.co.uk/rns/announcâŚ
2
27
3,968
#AVCT
ââWith an *exquisitely* selected FAP cleavage siteââ
What a video! đ¤Ż
Bring on SD. If this is anything to go by, then weâre going to be furnished with high-end material over the next 48 hours đ
avacta.com/therapeutics/
#AVCT
ââTransform patient outcomesââ
ââFirst-in-class cancer therapiesââ
ââpre|CISIONTM releases active drug *only* within the tumour microenvironmentââ
ââAvacta Therapeutics is a clinical-stage *pioneer* of next-generation cancer therapiesââ
đ¤Š
avacta.com/wp-content/uploadâŚ
Another AVA6000 update yesterday on PumChem. Weekly modifications are currently occurring, and this is all by way of the NIH database.
The NIH is Americaâs primary medical research agency.
#AVCT @Avacta đşđ¸
pubchem.ncbi.nlm.nih.gov/comâŚ
Another modification yesterday on PubChem for AVA6000 đ¤
@Avacta #AVCT
pubchem.ncbi.nlm.nih.gov/comâŚ
