Working on therapies for prevention and treatment of coronavirus. Transplant Infectious Diseases physician at Johns Hopkins. @ShohamTxID@med-mastodon.com
Baltimore, MD
Joined May 2015
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At our best infectious diseases experts can act as the synapses that connect surgeons, internists, pharmacists, microbiologists, epidemiologists and the patients to make good decisions.
We are excited for year two of the Pamela Tucker Course in Transplant and Oncology ID.
nam02.safelinks.protection.o…
"Crude 30-day mortality following a positive COVID-19 test was 2.2% in 2020, then decreased before stabilizing to 0.8%–1.0% from 2023 onward." Some people forget just how bad COVID was back then. academic.oup.com/ofid/articl…~
Triazole-resistant Aspergillus fumigatus in the Netherlands between 1994 and 2022: a genomic and phenotypic study - The Lancet Microbe thelancet.com/journals/lanmi…
Two Pandemics, Compared: Reflections on HIV and COVID-19 blogs.jwatch.org/hiv-id-obse…
Shmuel Shoham retweeted
A great opportunity for those wanting to learn and update themselves about infections in transplant and oncology patients.
hopkinsmedicine.org/infectio…
We are excited about this course. We are sure @Contagion_Live readers will find this course worthwhile
hopkinsmedicine.org/infectio…
We are excited about this course. We are sure @Contagion_Live readers will find this course worthwhile
Aspergillus tanneri fast facts: Tends to be resistant to multiple antifungal agents, described in people with chronic granulomatous disease (CGD) Western parts of US, living in Western parts of the US. Disseminated and contiguous disease patterns
Clinical situation: should you use vancomycin as part of empiric therapy in patient with AML and pneumonia.
Answer from clinical trial: Not typically, if MRSA screen is negative - Talagtag - 2021 - Transplant Infectious Disease - Wiley Online Library onlinelibrary.wiley.com/doi/…
Candida auris: a) adheres to skin and inanimate objects, b) colonization often clinically significant (compared to C. albicans), c) associated with outbreaks, d) often resistant to fluconazole, and sometimes echinocandins too. A good review article by Lionakis in NEJM in 2024
Teaching case: middle aged man with ulcerative colitis. Disease has been stable, but now seemingly flares. CMV viral load ~100K. Endoscopy: CMV colitis. CMV IgG had been negative previously. Now CMV IgM+. This is probably primary CMV infection with tissue invasive disease
For a patient in whom there is a high pre-test probability for Clostridium difficile infection: a positive C difficile PCR with a negative EIA for toxin, does not rule out C difficile. False negative tests for the EIA toxin do occur.
ID quiz: pt with neutropenia and blood culture with Rhodotorula. What is your fist line antifungal therapy
9%micafungin
0%fluconazole
73%amphotericin B
18%posaconazole
11 votes • Final resultsAspergillus calidoustus. I have seen it have a tendency for cutaneous involvement. Tends to be resistant to azoles. Here is another one from the literature. rdcu.be/eg2Fr.
Shmuel Shoham retweeted
Thank you to today’s panel of MMI Thursday Seminar presenters — David Sullivan, MD, & our guests from @HopkinsMedicine moderator Dan Hanley, MD, @ShohamTxID, Nicole McBee & Karen Lane! Great interactive discussion about their multi-center #COVID-19 clinical trial
Estimates of actual and potential lives saved in the United States from the use of COVID-19 convalescent plasma | PNAS pnas.org/doi/10.1073/pnas.24…
share.transistor.fm/s/e9646a…
new episode up: invasive candidiasis
many reasons why life expectancy in US is falling. I have to imagine the painfully system for getting medications covered by insurance companies is one of them. Without A LOT of work on the part of patients there are a million ways that things don't work out.
idsociety.org/news--publicat… via @IDSAInfo
Changes are needed badly. Thank you IDSA for working on this