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ALT Vaginal and urine samples showing endometrial cancer (true positive case; upper row) and no malignant cells (true negative case; lower row). Top row: SurePath (CytoRich Red, Becton, Dickinson and Company, Franklin Lakes, NJ, USA) cytology slides (Papanicolaou stain): endometrial adenocarcinoma. Urine sample, \u00D7 600 magnification (left) and vaginal sample, \u00D7 600 magnification (right) from the study participant SMH0170 showing adenocarcinoma, clinical outcome grade 1 stage IB endometrioid adenocarcinoma, true positive. Bottom row: SurePath cytology slides (Papanicolaou stain): no malignant cells seen. Urine sample, \u00D7 400 magnification (left) and vaginal sample, \u00D7 600 magnification (right) from the study participant SMH0212 with no malignant cells seen, true negative. Copyright: 2026 The Author(s). Published by Elsevier Ltd. CC BY 4.0.





























