@ShapiraLab

Director of the Systems Immunology Lab @NeckerINEM @Univ_Paris @CNRS. Dissecting virus-host interactions and revealing cell circuits controlling innate immunity

 Paris, France
Joined August 2019
  • Tweets147
  • Following491
  • Followers396
9Media
Goodbye NYC, bonjour Paris. After 10 years at Columbia University, a very exciting change on both a personal and professional level. NYC will always have a dear place in my ❤️ as do colleagues who I will surely miss, but boy am I excited for what’s ahead!
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This is so frickin good! Creative on all levels from beginning to end
Sketching Science@sketchscience20 Mar 2022
Wait... What!? Plants with Huntington's disease??? We introduced the toxic fragment of the mutant Huntingtin protein in Arabidopsis plants. (1/12) biorxiv.org/content/10.1101/…
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Are you really doing omics if you’re not doing multiomics?
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Sagi Shapira retweeted
INEM NECKER@NeckerInem11 Jan 2022
@NeckerInem is delighted to welcome Dr. Nicolas Venteclef @VenteclefNicol1, an internationally renowned expert in immunometabolism working on macrophages and type 2 diabetes, as new Group Leader, bringing considerable strength to our fundamental and translational activities.
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You know I’m huge fan, but this is truly inspired!
Harmit S. Malik@HarmitMalik6 Sep 2021
There's still lots to learn about chromatin complexity due to diversification of histone genes. A phylogenomic analysis of histone H2B genes led by @PravruthaRaman discovers 2 novel histones in mammals (incl humans), one of which is >400 million years old! biorxiv.org/content/10.1101/…

Novel classes and evolutionary turnover of histone H2B variants in the mammalian germline

Histones and their post-translational modifications facilitate diverse chromatin functions in eukaryotes. Core histones (H2A, H2B, H3, and H4) package genomes after DNA replication. In contrast,...

biorxiv.org
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I really enjoyed reading these two papers from the labs of @jkagan1 and @ClareBryant13. Congratulations to everyone involved! Folks interested in innate immunity, synthetic biology, evolution, or just good science, these are sure to become classics. immunology.sciencemag.org/co…
Clare Bryant ([email protected])@ClareBryant1324 Aug 2021
Replying to @jkagan1 @BobMPhD @pascal_devant
Here it finally is Jon cell.com/cell-reports/fullte…

Evolutionary loss of inflammasomes in the Carnivora and implications for the carriage of zoonotic...

Species of the order Carnivora have evolutionarily acquired the expression of a unique caspase-1/-4 hybrid protein. Digby et al. show that this protein is a poor mediator of NLRP3- and caspase-4-de...

cell.com
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Niiiiice!
Will Ratcliff
@wc_ratcliff5 Aug 2021
Well, this has been a long-awaited day- the first paper on our multicellularity Long Term Evolution Experiment (LTEE) is on the BioRxiv. Ever wonder how simple multicellular organisms evolve to become larger and more complex over thousands of gens? 1/35 biorxiv.org/content/10.1101/…
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Delighted to be kicking off the 2021 QBI Seminar series. This'll be fun!!
QBI@QBI_UCSF12 Jan 2021
Join us on January 27 at 11 AM PT for the first online #QBIseminar of the year featuring Sagi Shapira @ShapiraLab, hosted by Nevan Krogan @KroganLab! Find out more and register: qbi.ucsf.edu/seminar-shapira
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Sagi Shapira retweeted
Eric Topol
@EricTopol11 Jan 2021
That we only vaccinated 292,552 Americans today, having been able to hit 800,000 Thursday (7 Jan), speaks to the lack of any 24/7 plan or ability to execute. Emergencies don't take off weekends.
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I’m all for SciComm, but the explosion of discussion on Twitter about virus evolution and viral variants has devolved into a complete shit show, largely because of non-experts with blue checkmarks & large followings tweeting/publishing hyperbolic speculations. Needs to stop!
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Sagi Shapira retweeted
VIPR BRC@vipr_db4 Dec 2020
For anyone who missed this paper, @gorkalasso BarryHonig & @ShapiraLab use protein structure similarity to scan for molecular mimicry between host & viral proteins. Several interesting candidates identified in pox, herpes, paramyxo, and coronaviruses. doi.org/10.1016/j.cels.2020.…
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More awesome work from @mason_lab. Modern technology meets Jules Vern. Seriously, who wouldn’t find this super cool!? Beam me up Scotty.
Chris Mason
@mason_lab25 Nov 2020
Today we're elated to release a set of 30 papers on aerospace medicine and the biology of spaceflight; they are simultaneously featured on the covers of @CellCellPress, @CellReports, & @iScience_CP using photos taken by @StationCDRKelly while in space: cell.com/c/the-biology-of-sp… /1
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At what point does blatant endangerment of human health, promotion of crackpot science, and willful obstruction of efforts to limit future deaths fall under crimes against humanity? @IntlCrimCourt @HagueInstitute
Joe Lockhart@joelockhart16 Nov 2020
When the WH was asked this morning why they weren’t sharing Covid response info with the Biden team their answer was why should we. Not disputing Biden won, just saying they were under no obligation to help them. Let that sink in.
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🔥🔥🔥 #ByeByeTrump #FirstFemaleVicePresident #VotersDecided
Stefan
@SoupRS7 Nov 2020
Replying to @realDonaldTrump
@realDonaldTrump
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👏👏👏👏👏👏👏
Kamala Harris
@KamalaHarris7 Nov 2020
We did it, @JoeBiden.
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So proud of you. ❤️❤️🇺🇸🇺🇸
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And here it is, your Moment of Zen
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#BidenHarris2020 #collectivesighofrelief
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Sagi Shapira retweeted
Phys.org
@physorg_com27 Oct 2020
Coronaviruses are masters of #mimicry, new study finds @ColumbiaMed @NatureMedicine phys.org/news/2020-10-corona…

Coronaviruses are masters of mimicry, new study finds

Coronaviruses are adept at imitating human immune proteins that have been implicated in severe COVID-19 disease, a study from researchers at Columbia University Vagelos College of Physicians and...

phys.org
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Viruses frequently mimic host proteins (e.g. due to horizontal gene transfer). This paper uses protein structure similarity to scan for mimicry, and points to mimicry as a pervasive strategy employed by viruses. cell.com/cell-systems/fullte…
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