#Sepsis and #vasopressor pharmacist-scientist. #CriticalCare clinical pharmacist @ClevelandClinic. All tweets my own; RT does not mean endorsement
Cleveland, OH
Joined May 2014
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Seth Bauer retweeted
@SethRBauer next up on vasopressor choice after norepinephrine (NE) failure-
#CHEST2024
NE dose at which vasopressin should be started @gretchensacha ‘s paper journals.lww.com/ccmjournal/…
Vasopressin response: arterial PH and NE dose europepmc.org/article/pmc/88…
Cardiac function and vasopressor response ncbi.nlm.nih.gov/pmc/article…
Angiotensin II @KhannaAshishCCM refresher on ATHOS nejm.org/doi/full/10.1056/NE…
Renin and angiotensin II response: renin could be used as a bio marker pubmed.ncbi.nlm.nih.gov/3260…
Don’t miss out on downloading this great article before it goes behind the paywall
👀
A comprehensive rigorously composed list of renally-dosed and nephrotoxic medications - the #AKIP LIST!
The journal has made it open access til 10/05! Go get it and take a look!
journals.sagepub.com/doi/ful…
#Pharmacovigilance, #QI, #CDSS, the possibilities are endless!
Framing I didn’t previously consider (inspired by @pwierusz):
When the kidneys sense hypoperfusion they release renin to activate the RAS. Since the downstream effect of renin is to increase angiotensin II, the kidneys interpret hypoperfusion as a deficiency of angiotensin II.
This has me pondering for shock:
1️⃣Why do we use exogenous vasopressin for a “relative deficiency” but not angiotensin II for the same rationale?
2️⃣If we use angiotensin II for a “relative deficiency” why do we titrate the dosage instead of using a fixed dosage like vasopressin?
My current thinking is:
1️⃣We should consider angiotensin II for this rationale particularly if renin is “high” (atsjournals.org/doi/10.1164/…)
2️⃣🤷🏻♂️ but we probably should be titrating vasopressin and treating it as a vasopressor, not “endocrine replacement”😜
What do you think?
Thinking about vasopressor verbiage in light of a recent discussion with @pwierusz. Our thinking is aligned but I’m curious about your opinion. If a patient is on norepinephrine, vasopressin is added, then norepinephrine titrated off, is the vasopressin adjunctive or monotherapy?
26%Adjunctive
74%Monotherapy
23 votes • Final resultsThanks @lisa_burry! Poster can be reviewed/downloaded with the link below. Stay tuned for the manuscript - in peer review now. drive.google.com/file/d/1zRa…
This article from the Mayo pharmacy group (co-authored by @erin_barreto and @pwierusz) is downright amazing. 🔥 They have accomplished incredible things! After reading I immediately sent to our team as a model to emulate.
Seth Bauer retweeted
🚨NEW POD ALERT🚨
🧂Norepinephrine Position Paper & Sepsis Research Priorities 🥇
Ft. Brittany Bissell Turpin @BissellTurpin
Patrick Wieruszewski @pwierusz @mayoanesthesia @curiousboxwood
Seth Bauer @SethRBauer
History of norepinephrine formulation reporting 📜
Clinical & research implications ⚔️
Management in the drug shortage era 😬
Top 5 clinical sepsis research priorities 5⃣
Why this matters for more than just researchers ⭐️
Important basic science questions 🧑🔬
& much more!
(Listen to the intros for a surprise or two)
podcasts.apple.com/us/podcas…
open.spotify.com/show/4zYbVR…
Check out this new, comprehensive guideline on albumin use.👇🏻
TL;dr: Few indications where albumin use can be recommended (or even suggested).
It was a huge honor for me to work with and learn from this international group of expert methodologists, researchers, and clinicians.
New albumin guidelines from the International Collaboration for Transfusion Medicine.
Addressing ICU, CVSx, peds, cirrhosis, ARDS, volume overload, neonates, dialysis, and more!!
Check them out!
@ICTMG1 @JeannieCallum @SethRBauer @CanadasLifeline
pubmed.ncbi.nlm.nih.gov/3844…
It was such a pleasure to be invited to speak about my journey into research with the @umsop faculty. I’m very appreciate of Dr. @HeavnerPharmD’s invitation. 🙏🏻
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Seth Bauer retweeted
Original research suggests that implementing a protocol for peripheral administration of norepinephrine safely can avoid 1 central venous catheter day in the average patient. Read more in the February @journal_CHEST issue: hubs.la/Q02kh61X0
#MedTwitter #MedEd #CritCare
Huge congrats to @gretchensacha on being inducted as a fellow in ACCM. Well deserved recognition. #SCCM24
I’m so grateful to be able to chat with this group of outstanding pharmacist-scientists about problems few understand, but each of these folks have experienced and overcome.
#SCCM2024 is about 🍕 connections at James Beard restaurants.
Pictured - 3Ks, 1R01, and several other fed, foundation and industry awards.
More importantly pictured - people who have your back on all the unfunded ones.
#IDtwitter #PharmIcU #TwitteRx
@AndreaSikora
An outstanding presentation by @SheilaMyatra on the new SSC Research Priorities document. Check out the paper 👇🏻
journals.lww.com/ccmjournal/…
#SCCM2024 #SCCMSoMe @SheilaMyatra talking about research priorities in sepsis.
journals.lww.com/ccmjournal/…
Seth Bauer retweeted
#SCCM2024 #SCCMSoMe @SheilaMyatra talking about research priorities in sepsis.
journals.lww.com/ccmjournal/…
It was exciting to hear the fascinating work firsthand from @iamyourgasman and his team. Check out the link to their paper 👇🏻
Thanks for @SethRBauer letting us jump the queue for the #SCCM2024 Sepsis IV RST to present frontiersin.org/articles/10.… @karenkempsell1
And if you’re anywhere in the realm of #sepsis #septicshock #vasopressors #catecholamines #priorities then you would not want to miss @ESICM @SCCM joint session @skanegill @criticcaredoc we can’t wait to share what we have learnt with the world! @SOCCA_CritCare
Seth Bauer retweeted
And if you’re anywhere in the realm of #sepsis #septicshock #vasopressors #catecholamines #priorities then you would not want to miss @ESICM @SCCM joint session @skanegill @criticcaredoc we can’t wait to share what we have learnt with the world! @SOCCA_CritCare – at Winston-Salem, NC