@ScilabR
Joined September 2019
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analyticalsciencejournals.on… I am very excited to announce that our latest paper is finally out. We performed a systematic identification of ADAM17 substrates by proteomics, and developed a method to pick up those that are difficult to detect as they bind to HSPGs once released.

Development of a Proteomic Workflow for the Identification of Heparan Sulphate Proteoglycan‐Binding...

Ectodomain shedding, which is the proteolytic release of transmembrane proteins from the cell surface, is crucial for cell-to-cell communication and other biological processes. The metalloproteinase...

analyticalsciencejournals.onlinelibrary.wiley.com
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Proteomics Xmas Dinner. Thank you all for the amazing work you have done this year and for making our lab a nice place to work in!
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Congrats to Giulia Biundo who completed her MSc studies with honors. She did a great job in identifying protein markers of honey made by the Sicilian black honeybee by using mass spectrometry-based approaches. #apenera #slowfood #biodiversity
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Thank you to @ScilabR for the collaboration on ADAM15 - a truly mysterious ADAM that I still don't even vaguely understand. shorturl.at/bTX89
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We are hiring. Check this out fondazionerimed.eu/Contents/… – at Palermo, Sicily
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Proteases meeting in Kiel! Outstanding science and great time with my group. #proteases #conilsud #proteomics – at Kiel, Germany
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Proteomes | Free Full-Text | High-Resolution Secretome Analysis of Chemical Hypoxia Treated Cells Identifies Putative Biomarkers of Chondrosarcoma mdpi.com/2227-7382/10/3/25

High-Resolution Secretome Analysis of Chemical Hypoxia Treated Cells Identifies Putative Biomarkers...

Chondrosarcoma is the second most common bone tumor, accounting for 20% of all cases. Little is known about the pathology and molecular mechanisms involved in the development and in the metastatic...

mdpi.com
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Join this EMBO meeting on Structural Biology held in Palermo on 5-8 Sept 2022. Excellent Science, Terrific Venue! meetings.embo.org/event/22-s…

When predictions meet experiments: The future of structure determination

Figuring out the “protein folding problem”, that is predicting protein structure from the amino acid sequence, has stood as a grand challenge in biology for the past 50 years. Thanks to the efforts o…

meetings.embo.org
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Interested in TIMP-3? Check out our latest review! Tissue Inhibitor of Metalloproteases 3 (TIMP-3): In Vivo Analysis Underpins Its Role as a Master Regulator of Ectodomain Shedding mdpi.com/1493260 #mdpimembranes via @MDPIOpenAccess

Tissue Inhibitor of Metalloproteases 3 (TIMP-3): In Vivo Analysis Underpins Its Role as a Master...

The proteolytical cleavage of transmembrane proteins with subsequent release of their extracellular domain, so-called ectodomain shedding, is a post-translational modification that plays an essential...

mdpi.com
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Submit your paper to this special issue! mdpi.com/journal/membranes/s…

Ectodomain Shedding: Current Trends and Challenges to Investigate Functions of Sheddases | Membra...

About 25% of the coded proteins in the human genome are transmembrane proteins. The proteolytic release of transmembrane proteins, the so-called “ectodomain s...

mdpi.com
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Applications for this post-doc position close next week - contact me for more details if you're keen on joining us in Norwich to work on OA!
Troeberg lab@troeberg1 Mar 2021
More info on the post-doc position available in our lab - closing date 12 Apr. jobs.ac.uk/job/CEH633/senior…
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Sharing my experience in ERC Starting Grant (ERC StG) submission: @ERC_Research. Acceptance rate=12%. I spend 3.5 months w/ almost 100% effort. I learned a lot about myself by trying it. Here are 10 tips I share: (cond.)
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Check out our latest paper on IJMS. #conilsud | Quantitative Proteomics Reveals Changes Induced by TIMP-3 on Cell Membrane Composition and Novel Metalloprotease Substrates mdpi.com/1422-0067/22/5/2392

Quantitative Proteomics Reveals Changes Induced by TIMP-3 on Cell Membrane Composition and Novel...

Ectodomain shedding is a key mechanism of several biological processes, including cell-communication. Disintegrin and metalloproteinases (ADAMs), together with the membrane-type matrix metalloprote...

mdpi.com
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mdpi.com/1420-3049/26/4/944 Check out our latest review on ADAM17! #conilsud

Strategies to Target ADAM17 in Disease: From Its Discovery to the iRhom Revolution

For decades, disintegrin and metalloproteinase 17 (ADAM17) has been the object of deep investigation. Since its discovery as the tumor necrosis factor convertase, it has been considered a major drug...

mdpi.com
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I am pleased to announce that we are looking for a Research Assistant working with me on ADAMTSs & proteoglycans in thoracic aortic dissections and aneurysms: imperial.ac.uk/jobs/descript… @BSMB1 @UProteoglycans @IntSocMatBio
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DZNE  > Secretase-Meeting 2020: 3rd Kloster Seeon Meeting dzne.de/aktuelles/veranstalt…
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Great time with my group! Xmas party!
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Chosen for our Journal Club this week: iRhom2 inhibits bile duct obstruction–induced liver fibrosis stke.sciencemag.org/content/…
Institute retreat and lab meeting with a spleen sandwich! What’s better for great science?
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ERC starting grant just submitted! A crazy load of work, but worth it. Hope they will like it! Fingers crossed!
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