@ScienceWansang

Postdoc @Stanford Immune cell engineering in @ScienceKyle Lab. BS/PhD @SeoulNatlUni Chemical biology/drug discovery. Build better immunotherapy.

Joined September 2023
  • Tweets185
  • Following140
  • Followers36
1Media
Wansang Cho retweeted
Waggoner Lab@LabWaggonerOct 10
Spatiotemporal co-regulation of IL2 and TCR receptors reveals early antigen-driven synaptic synergy in human CD8+ T cells @NatureComms @CueBiopharma @MichaelLDustin @UniofOxford nature.com/articles/s41467-0…
8
52
3,232
Wansang Cho retweeted
Peter Du@peterdu_Sep 19
CRISPR screens are great at telling you what a gene is doing inside your cells. But what if you're interested in what's happening to its neighbors? Today, I'm excited to share match-seq, a new method that deciphers cell-cell interactions using barcoded RNA transfer. 1/9
9
64
4
266
58,114
Wansang Cho retweeted
Heczey Lab@HeczeyLabSep 10
Complete Regression of Hepatoblastoma after Interleukin-15– and Interleukin-21–Coexpressing CAR T-Cell Therapy | New England Journal of Medicine nejm.org/doi/full/10.1056/NE… @seattlechildren @TexasChildrens @NIH

Complete Regression of Hepatoblastoma after Interleukin-15– and Interleukin-21–Coexpressing CAR...

A 3-year-old boy with chemotherapy-resistant metastatic hepatoblastoma had complete regression lasting at least 12 months after two infusions of glypican-3–specific CAR T cells coexpressing interle...

nejm.org
4
29
3
100
9,054
Thoughts on CAR-T autoimmune deaths: a) Type of autoimmune dz likely matters, given underlying tissue pathology -> potential for adverse events (ex: vasculitis vs rheum). b) Polygenic factors cause autoimmunity, which could influence CAR-T phenotype, area needs to be explored
9
13
92
10,150
Excited to share our new preprint! We asked how inducible SynNotch-CAR circuits can better discriminate on-target from off-target cells when they share similar antigens. biorxiv.org/content/10.64898… Congratulations to Daniel Hoces, Jaclyn Ng and Julian Perez!
7
24
1
105
5,997
Wansang Cho retweeted
nature
@NatureAug 31
Nature research paper: A binding-to-release strategy for targeted anticancer drug delivery go.nature.com/46l6Bg2

A binding-to-release strategy for targeted anticancer drug delivery

Nature - A binding-to-release drug conjugate strategy enables targeted payload release without cellular internalization, improving tumour specificity, efficacy and expanding therapeutic targets...

nature.com
6
50
3
296
61,355
Wansang Cho retweeted
Waggoner Lab@LabWaggonerAug 29
Antibody Fc receptor CD16a mediates NK cell activation via mechanotransduction of piconewton forces @Stanford @ScienceAdvances science.org/doi/10.1126/scia…
7
38
2,485
Wansang Cho retweeted
Waggoner Lab@LabWaggonerAug 22
Enhanced antitumor immunity of mRNA vaccines by bioorthogonal-like delayed activation of exogeneous STING @NatureBiotech 🇨🇳 nature.com/articles/s41587-0…
13
1
38
2,757
Wansang Cho retweeted
Julia Carnevale
@jccarnevaleAug 17
Another major milestone for my lab - our second paper is out today in Nature Biotechnology! Co-led by @pascal_devant & @HyuncheolJung, with Alex Marson: nature.com/articles/s41587-0…

Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human...

Nature Biotechnology - Primary human myeloid cells are efficiently edited using virus-like particles.

nature.com
6
43
279
24,296
this is pretty cool: nature.com/articles/s41592-0…

Design and optimization of a kinase-controlled allosteric switch

Nature Methods - This Article introduces a phospho-switch for allosterically regulating target proteins in response to ERK kinase activity.

nature.com
23
126
14,508
Published this week @NatureMedicine, B7-H3 CAR T cells show promise in patients with rGBM! Congrats to all authors for another big step forward for our field. nature.com/articles/s41591-0…
2
19
101
12,162
Wansang Cho retweeted
AACR
@AACRAug 6
ICYMI: On the #AACRBlog— Read about three studies from #AACRio26 that leverage innovative science to give the immune system a better chance against cancer. brnw.ch/21x4JoA @idibaps @Stanford @MIT @ScienceWansang @MegTriesScience
5
4
2,208
Wansang Cho retweeted
Justin Eyquem@j_eyquemJul 29
Exciting collaboration with the Benoist lab! Using our mouse T cell engineering system that enables TCR replacement, we explored the roles of TCR/Antigen pairs in programing peripheral Treg ! cell.com/immunity/fulltext/S…

TCR origin and specificity to environmental or self-antigens on distinct antigen-presenting cells...

Using CRISPR-based TCR editing, Chi et al. systematically compare gut TCRs recognizing dietary, microbial, and self-antigens to define the principles that govern peripheral Treg cell differentiation....

cell.com
2
10
72
3,835
Wansang Cho retweeted
Bhardwaj Lab@BhardwajLabJun 10
Check out our latest review👏! We dive deep into how cDC1s orchestrate anti-tumor immunity through cross-presentation, immune networking, and spatial organization.
Journal of Experimental Medicine@JExpMedJun 10
Ward, Kar, Balan, and Bhardwaj @BhardwajLab review how conventional type 1 #DendriticCells (cDC1s) coordinate antitumor immunity through cross-presentation, immune cell networking, and spatial organization in tumors. hubs.la/Q04kVmqr0 #CancerFocus #Immunotherapy
11
41
4,921
Online now: Taxane chemotherapy promotes response to TIM-3 checkpoint blockade via STING-mediated ER stress and HMGB1 secretion dlvr.it/TSpzvr

Taxane chemotherapy promotes response to TIM-3 checkpoint blockade via STING-mediated ER stress and...

Onimus et al. find that select cytotoxic therapies induce active HMGB1 secretion and show combinatorial efficacy with anti-TIM-3 antibodies. Taxanes specifically promoted HMGB1 release via TLR4-dri...

cell.com
4
24
1,218
Wansang Cho retweeted
Jalal
@Jalal_AhmedMay 22
Thrilled to share our new paper out today in @NatureCancer: Tumor irradiation promotes antigen dressing of dendritic cells to enhance CAR T cell persistence and efficacy in lung metastases. A single dose of radiotherapy makes CAR T cells work against extensive metastatic lung cancer — even when the target antigen is also on normal tissues. nature.com/articles/s43018-0… 🧵 (1/14)

Tumor irradiation promotes antigen dressing of dendritic cells to enhance CAR T cell persistence...

Nature Cancer - Ahmed and colleagues show that, by promoting ‘dressing’ of intact tumor target antigens onto dendritic cells, tumor irradiation enhances chimeric antigen receptor T cell...

nature.com
10
30
2
102
26,579
Find this exciting work we pre-printed, of using SCRs to engineer user-defined macrophage states! Now, we can fine-tune cytokine signals with SCRs to design macrophage phenotypes. It is my pleasure to be part of this wonderful work!
Kyle G Daniels
@ScienceKyleMay 14
🚨What if we could reliably program macrophage polarization state?🚨 biorxiv.org/content/10.64898… Macrophages are highly plastic immune cells that perform critical functions by polarizing into distinct cellular states. The polarization state of macrophages can substantially influences the progression of cancers, infections, and autoimmunity. (1/11)
2
122
Wansang Cho retweeted
Kyle G Daniels
@ScienceKyleMay 14
🚨What if we could reliably program macrophage polarization state?🚨 biorxiv.org/content/10.64898… Macrophages are highly plastic immune cells that perform critical functions by polarizing into distinct cellular states. The polarization state of macrophages can substantially influences the progression of cancers, infections, and autoimmunity. (1/11)
10
89
5
330
25,770
Wansang Cho retweeted
Waggoner Lab@LabWaggonerMay 7
STING agonist nanoparticles trigger potent antitumor immunity in mice and rabbits @ScienceMagazine @UMich science.org/doi/10.1126/scie… science.org/doi/10.1126/scie…
22
78
4,894

No more items