
Daily post on science and medicine from @JohnDCook
Houston
Joined January 2012
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Science and Medicine retweeted
Time's running out!
Interested in discussing and understanding the fundamentals of electromagnetism? Join the all-star lineup for the Heaviside Symposium hosted by the Signals Museum in Huntsville, AL MLK Day Weekend. Submit your abstract today! aetherczar.substack.com/p/wi…
Science and Medicine retweeted
One thing that struck me while working in biostatistics was that every clinical trial had a convincing explanation for why it should succeed, though most did not.
That's why we have to run trials.
2/2
Science and Medicine retweeted
Saw a headline "T. Rex Had a Body Temperature of 97 Degrees".
That statement might be true, but it's certainly an extrapolation of a model. Safe to say nobody every stuck a thermometer up a dinosaur's butt.
Science and Medicine retweeted

Paul@WomanDefinerAug 15
United States
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I think the biggest scientific mystery on earth is the great unconformity, which is a barrier that has been observed globally where the rocks above a certain point are 500 million years old and the rocks below that line are 1.7 billion years old.
1.2 billion years worth of rock layers are missing and scientist best guess is maybe it was glaciers or plate tectonics but they don't know.
Science and Medicine retweeted
Pluto Might Be More Geologically Alive Than Anyone Realized
A new study led by Southwest Research Institute (SwRI) posits that liquid nitrogen is rising to Pluto’s surface through cracks in the northern edge of Sputnik Planitia, part of the massive heart-shaped glacier on the dwarf planet’s surface. This is the first evidence of liquid currently flowing on Pluto. For scale, Pluto is about three-quarters as wide as the continental United States. (Credit: NASA/Johns Hopkins APL/Southwest Research Institute)
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More on how Bessel functions relate to DNA structure
johndcook.com/blog/2026/08/0…
xitter.cf/AnalysisFact/status/20…
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A cranky formula for π
johndcook.com/blog/2026/06/0…
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For those unaware that the replication crisis has come for the “hard” sciences:
The US government’s Office of Research Integrity concluded Ariel Fernández had ‘intentionally, knowingly, or recklessly’ fabricated or falsified data across 12 research papers supported by grants from the US federal government.
@rebeccatrager99
chemistryworld.com/news/phys…
Science and Medicine retweeted
Consider the case of the discovery of Neptune in 1846. Uranus deviated from its predicted Newtonian path. Le Verrier predicted that an unknown perturbing planet must exist, calculated its mass and orbit, and Neptune was found almost exactly where predicted.
But the Neptune story is symmetric to a failure case. Mercury had an anomalous precession, where the ellipse that shows its orbit would rotate 43 arcseconds more per century than should be implied by the impact of other planets using Newtonian mechanics. This led astronomers to speculate that there's an unknown planet Vulcan within Mercury's orbit. But it was resolved in 1915 with Einstein's General Relativity.
A proper Newtonian would still proceed with the research agenda, but modify it as follows. First, you predict some unknown planet. If it can't be found, you say it's so small, it must require a bigger telescope, and you build a bigger telescope. And if you still can't find it, maybe there's a cloud of cosmic dust occluding it. If still not found, maybe the satellite's instruments are being screwed by some unknown magnetic field, and you send a new satellite. At each of these steps, had you discovered a new planet, or some unknown cosmic dust, or some new magnetic field, that would have been a sensational victory for Newtonians.
Ex ante, this is not unreasonable to do! It is only after decades or maybe centuries of patchwork that we can then analyze, are we simply adding epicycles, or is this theoretical framework progressive, in that it makes predictions we wouldn't otherwise be able to.
This illustrates why it's valuable to have many different research programs proceed in parallel. Only in retrospect do you realize whether an experiment actually dismantles the core of some big idea (in which case someone oughta work on an alternative) or is simply revealing an ancillary discovery that is compatible with the big idea (in which case someone oughta figure out how to make the two compatible while holding on to the old theory).
Lovely footnote from Imre Lakatos in his book on the scientific method which inspired some of this discussion: "If a scientist (or mathematician) has a positive heuristic, he refuses to be drawn into observation. He will 'lie down on his couch, shut his eyes and forget about the data'. Occasionally, of course, he will ask Nature a shrewd question: he will then be encouraged by Nature's YES, but not discouraged by its NO."
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Comparing Artemis II, Apollo 8, and Apollo 13
johndcook.com/blog/2026/04/0…
Science and Medicine retweeted
In 1980, a bioarchaeologist at Emory University named George Armelagos was studying ancient human bones from Sudanese Nubia, the kingdom that flourished along the Nile south of Egypt between roughly 350-550 CE, when something stopped him. Under ultraviolet light, the bones glowed.
They fluoresced with a distinctive yellow-green color that Armelagos recognized immediately, because the same glow appeared in the bones of modern patients who had been treated with tetracycline.
The antibiotic binds tightly to calcium and phosphorus in bone tissue as the body metabolizes it, leaving a permanent fluorescent marker. What Armelagos was seeing in bones nearly two thousand years old was chemically identical to what he saw in twentieth-century medical subjects.
The archaeological community was skeptical. The received history of antibiotics began with Alexander Fleming’s discovery of penicillin in 1928, and tetracycline itself was not isolated until 1948. The idea that a pre-literate population in the Nile valley had been routinely ingesting it seemed implausible, and the initial findings were dismissed as post-mortem contamination from soil bacteria.
Armelagos spent three more decades building the case. He eventually partnered with Mark Nelson, a leading tetracycline specialist at Paratek Pharmaceuticals, who agreed to perform a definitive chemical analysis.
The process required dissolving the ancient bones in hydrogen fluoride, one of the most corrosive and dangerous acids in existence. What the resulting liquid-chromatography mass-spectrometry analysis found was not a trace of tetracycline.
The bones were saturated with it. Multiple tetracycline variants were identified, including chlortetracycline and oxytetracycline, in concentrations indicating sustained exposure beginning in early childhood and continuing throughout life.
Ninety percent of the Nubian individuals tested showed the labeling. The exposure had not been accidental or occasional. It had been lifelong and deliberate.
The source was their beer.
Ancient Egyptian and Nubian brewing began with grain, typically emmer wheat or barley, which in that region was naturally contaminated with Streptomyces, a soil bacterium that produces tetracycline as a metabolic byproduct.
The grain was germinated, made into bread, then incompletely baked to preserve an active center, and finally fermented in vats of water. The standard practice was to seed each new batch with ten percent of the previous one, which kept the Streptomyces culture alive and active from batch to batch in a continuous chain.
The resulting brew was thick, sour, low in alcohol, and highly nutritious. Everyone drank it, including children as young as two years old.
The critical question Armelagos could not fully resolve was whether the Nubians understood what they were doing. The consensus among researchers is that they almost certainly did not know the mechanism.
They had no concept of bacteria, no understanding of antibiotics as a drug class, and no language for what tetracycline was doing in their bodies.
What they likely did know, accumulated through generations of observation and passed down as practical knowledge, was that this particular preparation of beer had medicinal effects.
Ancient Egyptian and Jordanian medical texts record beer being used to treat gum disease, wounds, and other infections.
The brewing method that produced tetracycline appears to have been deliberately maintained and refined over centuries, not by any understanding of the chemistry involved, but by the accumulated recognition that it worked.
#archaeohistories
Science and Medicine retweeted
If E=mc² and E=hf, then mass = frequency!
Sir Roger Penrose explains why every massive particle is an ultra-precise "little clock." By blending Einstein’s relativity with Planck’s quantum law, he shows the existence of mass implies a specific, insanely high-frequency vibration.
At the fundamental level, matter isn’t just “stuff”; it’s rhythmic energy keeping perfect time.
Credit: TheInstituteOfArtAndIdeas
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"I had a teacher that didn't like me and I didn't like him. At the end of the year he decided to fail me. The ironic thing is that the topic was chemistry. I have the distinction of being the only chemistry laureate who failed the topic in high school!"
- Tomas Lindahl
Science and Medicine retweeted
When 22 year old Lev Landau, openly challenged an equation in Albert Einstein’s lecture, at a 1930 physics conference in Leipzig.
Einstein Acknowledged the error and turned to the audience and said;
"The observation of that young man over there is perfectly correct. I therefore ask you to forget everything I have said to you today".
For Einstein, the moment became a legendary testament to his humility and commitment to scientific truth over personal pride.
( 📷 Albert Einstein, Lev landau )
Science and Medicine retweeted
The Ice Age is not over. The bigger picture is that we are still firmly in an ongoing ice age that began 34 million years ago during the Eocene-Oligocene transition. Most people associate the term 'ice age' with woolly mammoths, saber-toothed cats and the dramatic glacial advances of the Pleistocene - 'the Ice Age' in pop culture. This gets surprisingly little mainstream attention outside of paleoclimatology and geology circles.
This broader ice age setting is known as the Late Cenozoic Ice Age (also the Antarctic Glaciation). It began 34 million years ago when permanent ice sheets formed on Antarctica, triggered when CO₂ levels dropped below 750 ppm, opening up of ocean gateways like Drake Passage (creating the Antarctic Circumpolar Current to isolate Antarctica) and tectonic shifts that favored cooling. Before then, Antarctica hosted temperate rainforests, like modern Tasmania or New Zealand, with diverse flora and fauna, including early whales and penguins. They thrived in a warmer, Gondwana connected landscape, rivers and abundant life, eventually transitioning as the continent iced over.
The Late Cenozoic Ice Age is Earth's 'current icehouse' state, characterised by permanent polar ice caps. For the first 30 million years, glaciation was limited to the Southern Hemisphere. The start of the Quaternary glaciation 2.58 million years ago was the more recent and intense phase. Ice sheets began expanding into the Northern Hemisphere (the Greenland and Laurentide ice sheets during cold snaps). This process was driven by Milankovitch orbital cycles, leading to repeated glacial (cold and ice advances and retreats) and interglacial periods (warmer, when ice retreats).
Today's interglacial warm period — the Holocene — began 11,700 years ago and we are in a warm interglacial right now. This came at the end of the Last Glacial Maximum (26,000–19,000 years ago) and the brief Younger Dryas cold snap. The Holocene is just the latest interglacial within the Quaternary and is not the end of the ice age. There have been at least 40 interglacial cycles, perhaps more. None of this is a mystery for geologists and paleontologists. This broader picture of climate is rarely explained.
What defines an ice age in geological terms isn't just cold weather — it's the persistent presence of continental-scale ice sheets (like Antarctica and Greenland). During actual hot periods in Earth's history (much of the Mesozoic or early Cenozoic), there were no permanent polar ice caps. But as long as those massive ice volumes exist, the world is in icehouse conditions, even during warmer interglacials like ours. This narrative rarely makes it to the mainstream media.
The colloquial term 'Ice Age' almost always refers to the dramatic, recent Pleistocene glacial period that shaped human evolution, such as the megafaunal extinctions and glacial scarred landscapes in the Northern Hemisphere — things people can visualize easily.
The 34-million year timescale seems abstract compared with more relatable 100,000-year glacial-interglacial cycles. Media and education focus on the 'end of the last Ice Age' around 11,700 years ago - because that's when modern human civilisation (agriculture and cities) really took off. It's a reminder that the current warm, stable Holocene is only temporary in a far larger cold-dominated era.
Today's interglacial period could last another 10,000 to 50,000 years. Will it be affected by increases in CO₂ levels, already blamed for observable ice loss in Greenland and West Antarctica? The last interglacial was the Eemian, 130,000 to 115,000 years ago. It was far warmer than today with higher sea levels (6-9 meters above present) due to smaller ice sheets, particularly in Antarctica. African megafauna lived along the Thames estuary and Greenland mostly green pastures.
It serves as a valuable analogue, showing how polar regions and ice sheets respond to warming, suggesting significant Antarctic ice loss is driven by ocean warming. – at Bega, New South Wales
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Memorizing chemical element symbols
johndcook.com/blog/2026/01/0…































