@ScienceTM

Science Translational Medicine is the leading weekly online journal publishing translational research at the intersection of science, engineering and medicine.

 Washington, DC
science.org/journal/stm
Joined February 2011
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By applying a unique polyene scaffold, researchers engineer a next-generation, broad-spectrum #antifungal that selectively targets ergosterol without binding to cholesterol, avoiding severe toxicity linked to drugs like amphotericin B. scim.ag/4yyYZSP
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A new antifungal drug architecture combats infections in mice without the usual toxicity, a fluorescent imaging agent could enable more pinpointed removal of lung cancer tumors, and more in this week's new issue of #ScienceTranslationalMedicine. scim.ag/4z2AYEQ
Successful hematopoietic cell transplantation (HCT) requires immunosuppression to prevent graft-versus-host disease (GVHD), but the choice of regimen may shape immune reconstitution and GVHD risk. DeWolf et al. analyzed the T cell repertoires of clinical trial participants who received either tacrolimus and methotrexate (Tac/MTX) or posttransplant cyclophosphamide, mycophenolate mofetil, and tacrolimus (PT-Cy) as GVHD prophylaxis after HCT. PT-Cy more profoundly depleted the T cell compartment, creating a bottleneck as depicted on the cover, which resulted in a less diverse T cell repertoire. This reduced diversity was associated with lower GVHD risk but higher risk of infection after transplant. These findings show that immunosuppressive regimens can shape the balance between beneficial and harmful outcomes of HCT. Credit: N. Burgess/Science Translational Medicine

ALT Successful hematopoietic cell transplantation (HCT) requires immunosuppression to prevent graft-versus-host disease (GVHD), but the choice of regimen may shape immune reconstitution and GVHD risk. DeWolf et al. analyzed the T cell repertoires of clinical trial participants who received either tacrolimus and methotrexate (Tac/MTX) or posttransplant cyclophosphamide, mycophenolate mofetil, and tacrolimus (PT-Cy) as GVHD prophylaxis after HCT. PT-Cy more profoundly depleted the T cell compartment, creating a bottleneck as depicted on the cover, which resulted in a less diverse T cell repertoire. This reduced diversity was associated with lower GVHD risk but higher risk of infection after transplant. These findings show that immunosuppressive regimens can shape the balance between beneficial and harmful outcomes of HCT. Credit: N. Burgess/Science Translational Medicine

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AI is transforming the discovery and design of #antibiotics but requires concurrent progress in data standards, validation pipelines, and regulation to reach patients, argues a new Viewpoint. @delafuentelab @Hanqun_CAO @MIT_IMES scim.ag/4z09IH9
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In a new Editorial, researchers sound the alarm against the rising tide of rifampicin-resistant #tuberculosis and urge the need for an effective vaccine and control measures that integrate genomics and social interventions. @Unesp_Oficial @facfarmaciaUL scim.ag/47YQ7Lo
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A new Viewpoint discusses how integrating modernized commercial models, genomic surveillance, streamlined trial design, advances in #AI, and other innovations can tackle the dangers of #AntibioticResistance. @GSK scim.ag/4zEtNm7
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A small molecule therapy for #Alzheimers disease that activates #TREM2 in #microglia boosts the breakdown of amyloid-beta in neurons and mice and is well-tolerated in healthy individuals and patients, according to results from a phase 1 trial. @sanofi scim.ag/4jYmDEv
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A new Editorial stresses the importance of the simple but fundamental concept of prevention in combating antimicrobial resistance, and calls for more support for IPC and WASH in low- and middle-income countries to reduce antibiotic demand. @EdinUniUsher scim.ag/3Uv4kfY
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With tests in mice, researchers identify a new drug candidate delivered as a single, low dose to treat #schistosomiasis infection across the parasite's lifespan. scim.ag/4yvGu2q
Four panels show microscopic images of parasites. The top row depicts individual parasites labeled DMSO, MCLZ, M4339, and PZQ, all in different postures. The bottom row displays corresponding close-up textures of each parasite's surface.

ALT Four panels show microscopic images of parasites. The top row depicts individual parasites labeled DMSO, MCLZ, M4339, and PZQ, all in different postures. The bottom row displays corresponding close-up textures of each parasite's surface.

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Applying Fc engineering, researchers fashion potent bispecific antibodies against #SARSCoV2 that can be delivered via mRNA to target multiple viral epitopes and can constrain the virus’ ability to evade recognition. @moderna_tx scim.ag/47Vt445
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By parsing metabolic data from more than 18,000 participants in China, scientists have derived new “clock” models of metabolic #aging that incorporate novel metrics linked to higher chronic disease risk and all-cause mortality. @sjtu1896 scim.ag/4zzZLzU
A person rides a bicycle on a flat surface. The shadow cast on an orange background shows the person on a larger bicycle with clock faces as wheels.

ALT A person rides a bicycle on a flat surface. The shadow cast on an orange background shows the person on a larger bicycle with clock faces as wheels.

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