@SchroderLab
Joined January 2019
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  • Following37
  • Followers56
6Media
Happy to share our new Nat Commun paper on lipidic Abeta fibrils, we found some quite exotic structures. Congratulations to Benedikt and Mookyoung! link.springer.com/10.1038/s4…
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Cryo-EM Structures of Amyloid-β Fibrils from Alzheimer's Disease Mouse Models biorxiv.org/cgi/content/shor…
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SchroderLab retweeted
bioRxiv@biorxivpreprint3 Mar 2022
The 3D structure of lipidic fibrils of α-synuclein biorxiv.org/cgi/content/shor… #bioRxiv
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Are you a postdoc and work in the amyloid field? If so, be quick and apply for a talk at our "Amyloid postdoc day" on 25 November, 2021. More info at computationalbiochemistry.hh…
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Unser neues Heft 10/2021 ist draußen! Mit großem Special „Zelluläre Bildgebung" Außerdem: #SARSCoV2 & #COVID19 bei Kindern; Hijacking v. Journals; Proteinstrukturen m. #AlphaFold; 60 Jahre #Pipette; TA-Mangel im #Labor u.v.m. Das ganze Heft online hier: laborjournal.de/rubric/aktue…
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Eine KI hat ein kniffliges Probleme der #Molekularbiologie gelöst: die Vorhersage der dreidimensionalen Architektur von Proteinen. Das hat weit reichende Implikationen für Medizin und Biowissenschaften. Schöner Beitrag von Gunnar Schröder auf @spektrum. spektrum.de/magazin/molekula…
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New work from the labs of Wolfgang Hoyer & Hans Zempel and their collaborators: Endo-lysosomal Aβ concentration and pH trigger formation of Aβ oligomers that potently induce Tau missorting @LabZempel @SarahBchmnn @SchroderLab go.nature.com/3Cjbupy
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Are different aSyn-associated disease processes #Parkinson #msa related to different quaternary structures of aSyn fibrils: a-synuclein polymorphism determines oligodendroglial dysfunction (@mz_science great collaboration with Schröder and Xilouri labs) biorxiv.org/content/10.1101/…

α-Synuclein polymorphism determines oligodendroglial dysfunction

Synucleinopathies, such as Parkinson’s disease (PD) and Multiple System Atrophy (MSA) are progressive and unremitting neurological diseases. For both PD and MSA, α-synuclein fibril inclusions inside...

biorxiv.org
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"Challenges in sample preparation and structure determination of amyloids by Cryo-EM" In this review, Zielinski et al. discuss major developments in these cryo-EM techniques, automation and software — @fz_juelich #CryoEM #amyloids #JBCReviews jbc.org/article/S0021-9258(2…

Challenges in sample preparation and structure determination of amyloids by cryo-EM

Amyloids share a common architecture but play disparate biological roles in processes ranging from bacterial defense mechanisms to protein misfolding diseases. Their structures are highly polymorph...

jbc.org
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Engineering and application of a biosensor with focused ligand specificity disq.us/t/3rvba3q
Atomistic structure and dynamics of the human MHC-I peptide-loading complex [Biophysics and Computational Biology] pnas.org/content/early/2020/…
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Thanks to everyone for this fantastic collaboration!
Maximilian Zinke@ZinkeMaximilian13 Nov 2020
Are you interested in #NMR and #cryoEM, ...and in their integration? Then check out our latest paper where we use integrative #structuralbiology to describe the atomic structure and the dynamics of a #phage tail tube. @SchroderLab @szinn3 @LeibnizFMP nature.com/articles/s41467-0…
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SchroderLab retweeted
Filip Hasecke@FHasecke29 Jun 2020
Our most recent work is now available as a preprint. We present a potential pathway for toxic amyloid-beta oligomer production in Alzheimer's disease. @HHU_de
bioRxiv@biorxivpreprint29 Jun 2020
Endo-lysosomal Aβ concentration and pH enable formation of Aβ oligomers that potently induce Tau missorting biorxiv.org/cgi/content/shor… #bioRxiv
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It's exciting to share our #preprint of all my PhD work! We describe the structure determination of a flexible bacteriophage tail tube by integrating data from solid-state #NMR and #cryoEM. Combining both methods also enables the study of protein dynamics. biorxiv.org/content/10.1101/…

Spinal Column Architecture of the Flexible SPP1 Bacteriophage Tail Tube

Phage therapy has recently regained attention at combating multidrug-resistant bacteria. In 2019, tailed bacteriophages of the Siphoviridae family were engineered to successfully treat a disseminated...

biorxiv.org
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Integrated structural biology: effort based on solid-state #NMR (Adam Lange, FMP) #cryoEM (G. Schröder, Jülich) and modelling (M. Habeck, Jena) resulted in the complete atomic structure of flexible supramolecular assemby, the SPP1 bacteriophage tail tube; biorxiv.org/content/10.1101/…
Artist's impression of phages (green and yellow) attacking a bacterium (blue)

ALT Artist's impression of phages (green and yellow) attacking a bacterium (blue)

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Neuer Hinweis auf Zusammenhang zwischen #Alzheimer und #Diabetes - Hochaufgelöstes 3D-Modell zeigt starke Ähnlichkeit im Aufbau der Fibrillen fz-juelich.de/SharedDocs/Pre… @HHU_de @MaastrichtU
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Our new IAPP #amyloid fibril structure by #CryoEM @NatureSMB shows similarity to Abeta fibrils. @fz_juelich @HHU_de see full-text here: rdcu.be/b4UMh nature.com/articles/s41594-0…
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SchroderLab retweeted
chr.st.ne@chrstne_rdr15 Jun 2020
It is a happy Monday if you can share your recent work from @SchroderLab in collaboration with great colleagues from @HHU_de. Check out a new series of IAPP #amyloid fibril structures on the @NatureSMB website. #CryoEM nature.com/articles/s41594-0…
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#COVID19 Percent change of new COVID-19 cases per day in Germany. 0% would correspond to a linear growth of total number of infections.
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#COVID19 Percent change of new COVID-19 cases per day in Germany. 0% would correspond to a linear growth of total number of infections.
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